No abstract available.
Compliance* ; Hypertension* ; Korea*

No abstract available.
Asia* ; Hypertension*

In hypertensives, electrocardiographic left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease Animal and human studies suggest an association between left ventricular mass and dietary sodium (Na) intake. This study electrocardiographic LVH (S in VI + R in V5 > or = 3.5 mV). Blood pressure (BP), body in 40 otherwise healthy Korean patients with untreated essential hypertension on the standard Korean diet Among these variables, only Na excretion (mmol/day) was significantly different between those with and without LVH[LVH+:357+/-50, LVH-:268+/-25(p=0.04]. Thus, dietary sodium intake may be predictive of electrocardiographic LVH.
Animals ; Blood Pressure ; Cardiovascular Diseases ; Diet ; Electrocardiography* ; Humans ; Hypertension ; Hypertrophy, Left Ventricular* ; Korea ; Risk Factors ; Sodium ; Sodium, Dietary*

No abstract available.
Asian Continental Ancestry Group* ; Follow-Up Studies* ; Humans ; Hypertension* ; Mass Screening* ; Patient Education as Topic*

BACKGROUND: The development of post-traumatic heterotopic ossification (HO) is a common, undesirable sequela in patients with high-energy (war-related) extremity injuries. While inflammatory and osteoinductive signaling pathways are known to be involved in the development and progression of post-traumatic HO, features of the structural microenvironment within which the ectopic bone begins to form remain poorly understood. Thus, increasing our knowledge of molecular and structural changes within the healing wound may help elucidate the pathogenesis of post-traumatic HO and aid in the development of specific treatment and/or prevention strategies. METHODS: In this study, we performed high-resolution microscopy and biochemical analysis of tissues obtained from traumatic war wounds to characterize changes in the structural microenvironment. In addition, using an electrospinning approach, we modeled this microenvironment to reconstitute a three-dimensional type I collagen scaffold with non-woven, randomly oriented nanofibers where we evaluated the performance of primary mesenchymal progenitor cells. RESULTS: We found that traumatic war wounds are characterized by a disorganized, densely fibrotic collagen I matrix that influences progenitor cells adhesion, proliferation and osteogenic differentiation potential. CONCLUSION Altogether, these results suggest that the structural microenvironment present in traumatic war wounds has the potential to contribute to the development of post-traumatic HO. Our findings may support novel treatment strategies directed towards modifying the structural microenvironment after traumatic injury.