Traumatic supraorbital fissure syndrome (TSOFS) is a symptom complex caused by nerve entrapment in the supraorbital fissure after skull base trauma. If the compressed cranial nerve in the supraorbital fissure is not decompressed surgically, ptosis, diplopia and eye movement disorder may exist for a long time and seriously affect the patients′ quality of life. Since its overall incidence is not high, it is not familiarized with the majority of neurosurgeons and some TSOFS may be complicated with skull base vascular injury. If the supraorbital fissure surgery is performed without treatment of vascular injury, it may cause massive hemorrhage, and disability and even life-threatening in severe cases. At present, there is no consensus or guideline on the diagnosis and treatment of TSOFS that can be referred to both domestically and internationally. To improve the understanding of TSOFS among clinical physicians and establish standardized diagnosis and treatment plans, the Skull Base Trauma Group of the Neurorepair Professional Committee of the Chinese Medical Doctor Association, Neurotrauma Group of the Neurosurgery Branch of the Chinese Medical Association, Neurotrauma Group of the Traumatology Branch of the Chinese Medical Association, and Editorial Committee of Chinese Journal of Trauma organized relevant experts to formulate Chinese expert consensus on the diagnosis and treatment of traumatic supraorbital fissure syndrome ( version 2024) based on evidence of evidence-based medicine and clinical experience of diagnosis and treatment. This consensus puts forward 12 recommendations on the diagnosis, classification, treatment, efficacy evaluation and follow-up of TSOFS, aiming to provide references for neurosurgeons from hospitals of all levels to standardize the diagnosis and treatment of TSOFS.

Objective:To explore the exercise self-management cognition and real experience of elderly patients with colorectal cancer and sarcopenia, providing reference for the development of exercise intervention programs.Methods:This study was a descriptive qualitative research. From September to December 2023, purposive sampling was used to select 13 elderly patients with colorectal cancer and sarcopenia who visited Affiliated Hospital of Jiangnan University as participants, and face-to-face semi-structured in-depth interviews were conducted. Content analysis method was used to analyze, summarize, and extract themes from interview data.Results:Among the 13 elderly patients with colorectal cancer, there were six males and seven females aged 61 to 70 years. A total of three core themes and ten sub-themes were extracted, namely, cognition of disease and exercise (cognition of disease concepts, cognition of exercise self-management), diverse experiences of exercise self-management (positive support for exercise self-management, negative response to exercise self-management, and concerns about exercise self-management due to self-drag), and expectations for exercise self-management (information support and professional management needs, diversity needs of exercise content and methods, scientific needs of exercise volume and intensity, safety needs of exercise process, and systematic needs of system guarantees) .Conclusions:Elderly patients with colorectal cancer and sarcopenia have a certain level of enthusiasm and expectation for exercise self-management, but due to weak cognition of disease concepts and the benefits of exercise, self-drag, and insufficient system guarantees, there are negative responses to exercise. Medical and nursing staff need to strengthen their assessment of this population and develop scientific and systematic exercise intervention programs. The government and all sectors of society should actively guide people to have a positive cognition of diseases and provide certain policy guarantees.

Objective:To investigate the current status of vision-related quality of life in elderly patients with dry eye disease and explore its influencing factors.Methods:A convenience sampling method was used to select elderly patients with dry eye disease who visited the ophthalmology outpatient department of the Affiliated Hospital of Jiangnan University from June to December 2023. Data were collected using a general information questionnaire, the 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25), the Brief Illness Perception Questionnaire (BIPQ), and the Social Support Rating Scale (SSRS). Multiple linear regression analysis was conducted to identify factors influencing vision-related quality of life.Results:A total of 410 questionnaires were distributed and 407 valid responses were received, with an effective response rate of 99.3%. The mean score of NEI-VFQ-25 among the 407 elderly patients with dry eye disease was (61.14±18.11). Multiple linear regression analysis showed that illness perception, social support, education level, age, gender, smoking, and previous health education experience were significant factors influencing vision-related quality of life in these patients ( P<0.05) . Conclusions:Vision-related quality of life in elderly patients with dry eye disease is at upper middle level. Illness perception, social support, education level, age, gender, smoking, and health education experience are primary influencing factors. Targeted interventions by healthcare providers are necessary to improve the vision-related quality of life in elderly patients with dry eye disease.

Objective:To explore the exercise self-management cognition and real experience of elderly patients with colorectal cancer and sarcopenia, providing reference for the development of exercise intervention programs.Methods:This study was a descriptive qualitative research. From September to December 2023, purposive sampling was used to select 13 elderly patients with colorectal cancer and sarcopenia who visited Affiliated Hospital of Jiangnan University as participants, and face-to-face semi-structured in-depth interviews were conducted. Content analysis method was used to analyze, summarize, and extract themes from interview data.Results:Among the 13 elderly patients with colorectal cancer, there were six males and seven females aged 61 to 70 years. A total of three core themes and ten sub-themes were extracted, namely, cognition of disease and exercise (cognition of disease concepts, cognition of exercise self-management), diverse experiences of exercise self-management (positive support for exercise self-management, negative response to exercise self-management, and concerns about exercise self-management due to self-drag), and expectations for exercise self-management (information support and professional management needs, diversity needs of exercise content and methods, scientific needs of exercise volume and intensity, safety needs of exercise process, and systematic needs of system guarantees) .Conclusions:Elderly patients with colorectal cancer and sarcopenia have a certain level of enthusiasm and expectation for exercise self-management, but due to weak cognition of disease concepts and the benefits of exercise, self-drag, and insufficient system guarantees, there are negative responses to exercise. Medical and nursing staff need to strengthen their assessment of this population and develop scientific and systematic exercise intervention programs. The government and all sectors of society should actively guide people to have a positive cognition of diseases and provide certain policy guarantees.

Objective:To investigate the current status of vision-related quality of life in elderly patients with dry eye disease and explore its influencing factors.Methods:A convenience sampling method was used to select elderly patients with dry eye disease who visited the ophthalmology outpatient department of the Affiliated Hospital of Jiangnan University from June to December 2023. Data were collected using a general information questionnaire, the 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25), the Brief Illness Perception Questionnaire (BIPQ), and the Social Support Rating Scale (SSRS). Multiple linear regression analysis was conducted to identify factors influencing vision-related quality of life.Results:A total of 410 questionnaires were distributed and 407 valid responses were received, with an effective response rate of 99.3%. The mean score of NEI-VFQ-25 among the 407 elderly patients with dry eye disease was (61.14±18.11). Multiple linear regression analysis showed that illness perception, social support, education level, age, gender, smoking, and previous health education experience were significant factors influencing vision-related quality of life in these patients ( P<0.05) . Conclusions:Vision-related quality of life in elderly patients with dry eye disease is at upper middle level. Illness perception, social support, education level, age, gender, smoking, and health education experience are primary influencing factors. Targeted interventions by healthcare providers are necessary to improve the vision-related quality of life in elderly patients with dry eye disease.

Objective:To explore the categories and influencing factors of family caregivers′benefit finding in patients with esophageal cancer based on latent profile analysis.Methods:From May 2020 to February 2021, 255 primary family caregivers of patients with esophageal cancer in the First People′s Hospital of Changzhou and Affiliated Hospital of Jiangnan University were selected for the study using a cross-sectional survey method. Surveys were conducted by the General Information Questionnaire, the Benefit finding Scale, the Hospital Anxiety and Depression Scale, and the Event Related Rumination Inventory.Results:The benefit finding among family caregivers of patients with esophageal cancer was divided into 2 latent profile classifications, low benefit rumination group 33.3% (85/255) and high growth adaptation group 66.7% (170/255), and the results of binary Logistic regression analysis showed that caregivers with high school education or above ( OR=0.053, P<0.05) and higher deliberate rumination scores ( OR=0.778, P<0.01) had a higher degree of benefit finding; caregivers with higher intrusive rumination scores ( OR=1.163, P<0.05) and higher anxiety ( OR=1.323, P<0.01) and depression scores ( OR=1.128, P<0.05) had a lower benefit finding. Conclusions:There is heterogeneity in the caregiver′s benefit finding of patients with esophageal cancer. Health professionals and nursing staff should develop targeted psychological support and interventions to improve the caregiver ′s benefit finding according to the different sub-types of caregivers.

Objective:To investigate the correlation between the high-resolution magnetic resonance imaging (MRI) vessel wall characteristics and risk of ischemic stroke in patients with middle cerebral artery (MCA) atherosclerotic stenosis.Methods:Patients with ischemic cerebrovascular disease treated in the Department of Neurology, Nanjing First Hospital, Nanjing Medical University from January 2016 to January 2020 were enrolled prospectively. The patients presented with transient ischemic attack or acute ischemic stroke (AIS). Magnetic resonance angiography showed that the ipsilateral MCA had stenosis of 50%-99%, and it was identified as the responsible lesion. Routine MRI and the vessel wall imaging at the narrowest part of MCA were performed. The characteristics of vessels and plaques at MCA stenosis were compared between the AIS group and the non-AIS group. Multivariate logistic regression analysis was used to determine the independent risk factors for AIS. Receiver operating characteristic (ROC) curve was used to determine the predictive value of vessel wall characteristics for AIS. Results:A total of 65 patients with ischemic cerebrovascular disease and MCA stenosis were enrolled. The age of patients was 68±14 years, 50 were males (76.9%). There were 30 patients (46.2%) in the AIS group and 35 (53.8%) in the non-AIS group. There were no significant differences in demographic data, vascular risk factors and routine laboratory tests between the two groups. Compared with the non-AIS group, the narrowest lumen area in the AIS group (2.36±1.09 mm 2vs. 2.96±1.01 mm 2; t=2.274, P=0.027) was smaller, the plaque area (4.46 ±2.08 mm 2vs. 2.62±1.32 mm 2; t=4.315, P<0.001) was larger, the remodeling index (1.08±0.11 vs. 0.94±0.10; t=5.573, P<0.001) was higher, and the proportion of obvious enhanced plaque (63.3% vs. 11.4%; χ2=19.034, P<0.001) and positive remodeling plaque (80.0% vs. 20.0%; χ2=23.311, P<0.001) were higher. Multivariate logistic regression analysis showed that plaque area (odds ratio [ OR] 2.01, 95% confidence interval[ CI] 1.35-2.98; P=0.001), remodeling pattern ( OR 16.00, 95% CI 4.73-54.15; P=0.001), the narrowest lumen area ( OR 0.568, 95% CI 0.34-0.96; P=0.033) and degree of enhancement ( OR 21.85, 95% CI 5.13-93.00; P<0.001) were the independent risk factors for AIS. ROC curve analysis showed that the combination of plaque area, the narrowest lumen area and the degree of enhancement had the best prediction effect (area under the curve 0.927, 95% CI 0.84-0.96). Conclusion:AIS is more likely to occur when the plaque area at the narrowest part of the MCA is larger, the lumen area is smaller, and there is obvious plaque enhancement.

Objective:To investigate the regulatory mechanism and clinical significance of RASSF5 in cutaneous melanoma.Methods:We used GEPIA and HPA online tools and TCGA and GSE53118 data sets for differential expression analysis and prognosis analysis; cBioPortal was applied to analyze the correlation between RASSF5 expression and gene mutation and methylation; "limma" R package was used to screen differential genes for GO analysis, KEGG analysis and protein-protein interaction analysis, and we also performed GSEA analysis on all genes; finally we used ESTIMATE and CIBERSORTx online tools to evaluate immune cell infiltration. The kruskal test was used to compare the differences between the groups for measurement data, the Kaplan-Meier method was used to draw the survival curve, and the Cox proportional hazard regression model was used for univariate and multivariate analysis.Results:This study found that in cutaneous melanoma, the expression level of RASSF5 was significantly lower than that of normal tissues, and the methylation level was negatively correlated. KEGG analysis and GSEA analysis showed that RASSF5 can be related to multiple signaling pathways such as immune regulation, KRAS, and P53. Further analysis showed that the expression level of RASSF5 was positively correlated with the degree of infiltration of a variety of tumor immune cells. Survival analysis found that the expression level of RASSF5 was correlated with the overall survival rate of patients with cutaneous melanoma, and multivariate regression analysis found that RASSF5 was an independent predictor of cutaneous melanoma. Finally, using the GSE53118 dataset to verify again, RASSF5 is related to the overall survival rate of patients with cutaneous melanoma and can be used as an independent predictor.Conclusions:RASSF5 may regulate the occurrence and development of cutaneous melanoma cells through a variety of ways. It is a potential biological prognostic marker and therapeutic target.

Objective:To investigate the regulatory mechanism and clinical significance of RASSF5 in cutaneous melanoma.Methods:We used GEPIA and HPA online tools and TCGA and GSE53118 data sets for differential expression analysis and prognosis analysis; cBioPortal was applied to analyze the correlation between RASSF5 expression and gene mutation and methylation; "limma" R package was used to screen differential genes for GO analysis, KEGG analysis and protein-protein interaction analysis, and we also performed GSEA analysis on all genes; finally we used ESTIMATE and CIBERSORTx online tools to evaluate immune cell infiltration. The kruskal test was used to compare the differences between the groups for measurement data, the Kaplan-Meier method was used to draw the survival curve, and the Cox proportional hazard regression model was used for univariate and multivariate analysis.Results:This study found that in cutaneous melanoma, the expression level of RASSF5 was significantly lower than that of normal tissues, and the methylation level was negatively correlated. KEGG analysis and GSEA analysis showed that RASSF5 can be related to multiple signaling pathways such as immune regulation, KRAS, and P53. Further analysis showed that the expression level of RASSF5 was positively correlated with the degree of infiltration of a variety of tumor immune cells. Survival analysis found that the expression level of RASSF5 was correlated with the overall survival rate of patients with cutaneous melanoma, and multivariate regression analysis found that RASSF5 was an independent predictor of cutaneous melanoma. Finally, using the GSE53118 dataset to verify again, RASSF5 is related to the overall survival rate of patients with cutaneous melanoma and can be used as an independent predictor.Conclusions:RASSF5 may regulate the occurrence and development of cutaneous melanoma cells through a variety of ways. It is a potential biological prognostic marker and therapeutic target.