Carcinoma ; pathology ; surgery ; Carcinoma, Papillary ; Humans ; Neck Dissection ; Thyroid Neoplasms ; pathology ; surgery

Objective To investigate the sorts and quantities of air fungi in air and its change in every month in the west of Luzhou City. Methods The experiment glass slice was exposed every day and the experiment container was exposed every month in one year so as to investigate air fungi in Luzhou Library Building in the west of Luzhou City. The fungi were separated and cultured, the specimens of fungi were pressed on glass slice timely, dyed with methyl blue and identified. Results 365 experiment glass slices were exposed every day in one year. 24 139 fungi spores were checked and 23 582 were identified. They belonged to 24 species. The air fungi spores in the experiment glass slice according to their quantity were Alternaria(30.61%), Ustilaginales(23.90%), Epicoccum(18.71%), Hormodendrum(13.91%). The air fungi in the experiment container according to their quantity were Saccharomyces(50.20%), Aspergillus(12.46%), Penicillium(10.77%), Hormodendrum(9.29%) and so on. There were a lot of air fungi in the west Luzhou City all the year round. The air fungi quantity was high during May to September in a year. Conclusion A lot of fungi wave to and fro in air in the west of Luzhou City all the year round. The quantity of air fungi changes as the season goes on and it is high during May to September. The main fungi are Alternaria, Ustilaginales, Epicoccum, Hormaodendrum and so on.

Through literature review,Delphi method and analytic hierarchy process,the construction and implementation of evaluation system on researchers' performance is in accordance with characteristics and practical requirements of Peking University Cancer Hospital & Institute,19 key indicators,which fall into 3 categories of work aptitude,work behavior,and work effectiveness,were set up as the basic structure,and upon wich the development and implementation of performance evaluation system is based and possible effects and results were discussed.

Objective: To study the identification between the Amomum villosum hybrid offspring and the female parent by useing the Fourier transform infrared (FTIR) spectroscopy. Methods: Using the FTIR to determine the infrared spectra of A.villosum hybrid offspring and female parent. Switching and processing the atlas with derivative spectrometry and Fourier self-deconvolution, to contrast for the characteristic differences in absorbance of them. Results: There were no significant differences between the A. villosum hybrid offspring and female parent by using FTIR. But 1 051.014 cm-1 was found to be the most obvious in the fourth-derivative spectrum, 771.563 4 and 1 612.432 5 cm -1 to be the most obvious in the Fourier self-deconvolution spectra. Conclusion: There are obvious differences between the A. villosum hybrid offspring and female parent in the derivative spectrometry and Fourier self-deconvolution spectroscopy atlas. Therefore, this method can be used to identify the A.villosum hybrid offspring and female parent simply, rapidly, and accurately.

Objective: To establish the quality standard for Tiaolitongbao I capsules.Methods: The components including Astragalus , Atractylodes, Finger citron and Radix aucklandiae were identified by TLC.Emodin, the effective component of Polygonum cuspidatum , was determined by HPLC.Results: The characteristic spots in TLC were clear without any interference.The linear range of emodin was 4.25-68.00 μg·ml-1 (r =0.999 9).The average recovery was 95.22% ,and RSD was 1.47% (n =6).Conclusion: The methods used for the identification and quantification are sensitive, simple and accurate, which can be used for the quality control of Tiaolitongbao I capsules.

Objective To investigate the correlation between ultrasonographie classification, age and lesion in female. Methods One thousand two hundred and eight patients with 2416 mammary gland were comfired by pathologic findings, including 132 benign lesion and 54 malignancy lesion. According various sonographic appearances in the mammary gland structure and involution grade, the mammary glonds were classified into glandular,fibroglandular and fatty types. A single mammary gland is statistic unit. Results To follow age growth, the proportion of glandular type was decrease, 61.7% in under 30 years of age,31.5% in 30-39 years of age,15.3% in 40-49 years of age,8.6% in 50-59 years of age,4.5 in over 60 years of age. To follow age growth, the proportion of fatty type was higher, 1.6 % in under 30 years of age, 5.80% in 30-39 years of age,5.5% in 40-49 years of age,10.8% in 50-59 years of age,38.6% in over 60 years of age. Before 60 years of age, to follow age growth, the proportion of fibroglandular type was higher, which achieved the peak value (79.2%) in 40-49 years and last to 50-59 years of age (80.6%) ,but it was decrease to 56.9% after 60 years of age. There was significant difference of the proportion in any age(P=0.000).The proportion of the benign lesion no difference in three categories. The proportion of malignancy lesion (6.23%, 16/257 mammary gland)in fatty type was higher than that in fibroglandular type (2.18%,37/1698 mammary gland) which was significant difference(P=0.000). There was no malignancy lesion in glandular type. Conclusions Significant correlation were present between uhrasonographic classification, age and malignancy lesion, no significant correlation were found between uhrasonographic classification, age and benign lesion.

OBJECTIVE:To establish and carry out total quality management and evaluation system in hospital pharmacy. METHODS: The background and the implementation steps of the total quality management in hospital pharmacy were analyzed and summarized. RESULTS: Seven steps were included in total quality management of hospital pharmacy, i.e. role shifting of drug control room, transpositional thinking, orientation defining, network construction of quality management, improvement of quality management regimen, fusion of quality management with the construction of department culture. CONCLUSIONS: The practice of the new model of the total quality management in hospital pharmacy has contributed to the preliminary establishment of the quality evaluation standard for dispensing as well as the forming of the total quality control system in hospital pharmacy and the upgrading of the scientific management in hospital pharmacy.

PurposeTo analyze the sonographic and the histological features of special types of breast malignant tumors in order to explore preoperative ultrasound diagnosis. Materials and Methods Seven cases of special types of breast malignant tumors confirmed by pathology were retrospectively investigated by ultrasound. The sonographic and histological features of the lesions were reviewed. The ultrasonogram manifestations of the breast anatomy and the lesions were observed and recorded.Results Among 7 cases, there were 2 cases of papillary carcinoma, 3 cases of mucinous carcinoma, and 2 cases of lymphoma. Microscopically, the papillary carcinoma had clear boundaries with infringing mesenchyme, and the tissues were papillary and dense. The mucinous carcinoma had cancer cells floated in mucus lake. The primary breast lymphoma was diffused large B-cell type with focal lesion. For sonography type of breast, there were 3 cases of fatty types, 1 case of fibroglandular-1 and 3 cases of fibroglandular-2. The papillary carcinoma was hypoechoic in 2 cases, one of them was expansive growth with large size. Two cases of mucinous carcinoma were hypoechoic without accompanying sound attenuation in 1 case and with accompanying acoustic shadow due to calcification in the other case. Lymphoma was apparent anechoic and cystoid.Conclusion Special types of breast malignancies have different sonographic features and histological features from the common invasive ductal carcinoma. It has high clinical significance to enhance the understanding of rare malignant breast tumors.

OBJECTIVETo compare the difference of Euphorbia Pekinensis Radix before and after being processed with vinegar in the toxicity on rat small intestinal crypt epithelial cells IEC-6, and make a preliminary study on the mechanism of detoxication of Euphorbia Pekinensis Radix processed with vinegar.

METHODWith rat small intestinal crypt epithelial cells IEC-6 as the study object, the MTT method was adopted to detect the effect of Euphorbia Pekinensis Radix before and after being processed with vinegar on IEC-6 cell activity. The morphology of cells were observed by the inverted microscope. The down-regulated mitochondrial apoptosis pathway of enterocytes caused by the vinegar processing was analyzed by using the high content screening.

RESULTCompared with the negative control group, the proliferation inhibition experiment showed that Euphorbia Pekinensis Radix showed a relatively high intestinal cell toxicity (P < 0.01). The results of HCS analysis showed that Euphorbia Pekinensis Radix could significantly reduce the cell nucleus Hoechst fluorescence intensity and mitochondria membrane (P < 0.05, P < 0.01), and increase Annexin V-FITC and PI fluorescence intensity and membrane permeability (P < 0.01, P < 0.01, P < 0.01). After being processed with vinegar, compared with Euphorbia Pekinensis Radix groups with different doses, Euphorbia Pekinensis Radix processed with vinegar could significantly decrease the cell proliferation inhibition effect on enterocytes, increase the cell nuclear Hoechst fluorescence intensity and mitochondria membrane (P < 0.05, P < 0.05), and decrease Annexin V-FITC and PI fluorescence intensity and membrane permeability (P < 0.01, P < 0.01, P < 0.05), and showed a certain dose-effect relationship.

CONCLUSIONThe vinegar processing can further reduce the toxicity of Euphorbia Pekinensis Radix on enterocytes. Its possible mechanism can decrease the effect of Euphorbia Pekinensis Radix on the permeability of IEC-6 cell membrane, so as to provide a basis for further explanation of the detoxication mechanism of Euphorbia Pekinensis Radix processed with vinegar.

Acetic Acid ; chemistry ; Animals ; Apoptosis ; drug effects ; Cell Line ; Cell Proliferation ; drug effects ; Cell Survival ; drug effects ; Chemistry, Pharmaceutical ; methods ; Drugs, Chinese Herbal ; chemistry ; toxicity ; Epithelial Cells ; cytology ; drug effects ; Euphorbia ; chemistry ; Intestine, Small ; cytology ; Rats

To investigate the cognition and attitude towards ethical,legal,medical,social issues caused by associated reproductive technology (ART) among adults in Heilongjiang Province,and to provide scientific basis for evaluating ART and formulating related policies.A total of 220 residents from Harbin,Qiqihar,and Daqing in Heilongjiang Province were invited to the present study.The cognition and attitude towards ART was investigated using a self-designed questionnaire.Adults in Heilongjiang Province had generally high cognition level of informed consent,ethical review,legal protection and social cognition,etc.But there was still a large ambiguity of detailed issues such as the function of ethical review,treatment abandoning,the potential risks and so on.It should strengthen the function of Institutional Review Board,continuously improve the mechanism of risk assessment and supervision,carry out health education and health promotion,establish a multi-disciplinary cooperation team,and reach a consensus among professionals,government policy makers and public representatives,so as to facilitate the healthy development of ART.