150 slides of vaginal sample of married women aged 16-49 years old at 8 village of Ha Tay province were investigated. In 51.6% of subjects, there is not pathological manifestation in 48.3% - inflammative damages, then 38.6% with chronical manifestation and 12.6% with acute PaP1 account for 62.6%, PaP2: 24.5% and PaP3: 0.13%. There is not any cancerous damage. Hygiene condition, obstetrical history and venerological diseases were factors related to inflammative state and cervix cell morphology change
Women ; epidemiology ; Cervix Uteri ; cells

From 1996 to 2000, 73 samples of renal biopsy in patients >16 years old with glomerulonephritis and nephrotic syndrome were study on light microscopy. Results: the rate of minimal change glomerulopathy was highest (72.6%), then was the rate of diffuse mesangial proliferative glomerulonephritis (20.6%). The rates of focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, and membranous glomerulonephritis in this study were lower than the other studies. The changes in minimal change glomerulopathy are glomerular basement membrane thickened irregularly, widening and effacement of the visceral epithelial cell foot processes
Glomerulonephritis, Membranous ; Nephrotic Syndrome ; Patients

Crocin is a chemical extraction from saffron and it is the most important kind of pigment of saffron.Recently,the research on cervical cancer,bladder cancer,leukemia,tongue squamous cell carcinoma,colon cancer,pancreatic cancer shows that crocin has a role in inducing apoptosis of the tumor cells by activating caspase-3,regulating the ratio of bcl-2/bax and repressing the expression of survivin.Crocin has a strong inhibitory effect on tumor proliferation by inducing cell cycle to arrest through down-regulating the expression of cyclin D1 and up-regulating the expression of p27kip1.Crocin can also exert antitumor effects by liposome encapsulation to enhance cytotoxic effect.Crocin is a kind of effective chemical for tumor treatment and prevention with no significant toxico-and by-effect in vivo,and is likely to be used as an anticancer drug clinically in the future.

Objective To investigate the therapy effect and adverse reaction of the abraxane chemotherapy as a alternative plan in metastatic breast cancer.Methods Twenty-one patients with advanced metastatic breast cancer were selected as our subject.All the patients received rescue chemotherapy after relapse and metastasis.Abraxane were administrated with 260 mg/m2 3 weeks/time,and evaluated the effect in every two course of radiotherapy.Results Of 21 cases,4 cases were remission and 8 cases were with stable progress of cancer.No allergic reaction occurred.The majority adverse reaction were granulocytopenia and nerve toxicity.Conclusion Abraxane migh be considered as the altemate therapy medicine of metastatic breast cancer due to good curative effect,less toxicity reaction and no allergic reaction.

Objective To investigate the clinical effect of low molecular weight heparin calcium combined with urease on intravenous thrombolytic therapy for myocardial infarction,and evaluate its safety.Methods One hundred and seven patients diagnosed myocardial infarction were randomly divided into the observation group (n =54) and control group (n =53),who were hospitalized in Yantai Central Hospital from January 2011 to December 2012.Patients in control group were given regular treatment plus basic support treatment for the symptomatic.Patients in the observation group were treated intravenous thrombolysis,subcutaneous low molecular weight heparin besides the basic treatment,10 d as a course of treatment.Observed the therapeutic effect in patients,observed and evaluated the safety of using two drugs in combination therapy group.Results (1) The recanalization rate of coronary artery in observation group was 83.33％ (45/54),higher than that in the control group (60.38％ (32/53),x2 =4.296 ; P ＜ 0.05).(2) The time of ST-T dropped back to 50％ in the observation group was (2.0 ±0.6) h,and recanalization time was (1.3 ±0.4) h,less than that in the control group (3.4 ± 0.5) h,(2.1 ± 0.3) h respectively),and the difference were significant (t =2.948,P ＜0.05 ; t =3.186,P ＜ 0.05).(3) Incidence of complications in the observation group was 44.44％ (24/54),significantly less than that of the control group (77.36％ (41/53) ; x2 =3.918,P ＜ 0.05).Two cases of the observation group were with reinfarction,accounting for 3.70％ and 9 cases in the control accounting for 16.98％.The difference was statistically significance (x2 =4.142 ; P ＜ 0.05).Conclusion The therapy plan of low molecular heparin combined with urease intravenous thrombolytic therapy for myocardial infarction can significantly improve the clinical effect of patients,reduce the complications and the incidence of myocardial infarction.It was proved as a safe and effective therapy plan in improving the prognosis of patients.

Teaching quality is the basis of higher education.This article compared the results of teaching supervision and evaluation between campus and affiliated hospitals of Qiqihar Medical University in 2011.Differences were found out and corresponding strategies were proposed in order to improve the teaching quality and train high-quality talents.

Surgical therapy should be the main method in treatment of rectal cancer.Along with the increase rate of undergoing anterior resection for rectal cancer,it is getting be paid more and more attention on postoperative anastomotic fistula as the main complications of rectal carcinoma.In recent research,anastomotic fistula occurred caused by various factors had also been put forward gradually,while the risk factors for postoperative anastomotic fistula were still remain unclear.Therefore,it is very important to understanding the risk factors in order to prevent the happening of the anastomotic fistula,and provide clinical basis for their necessary preventive colostomy.

Objective To summarize the prevention and treatment of hand food and mouth disease　(HFMD),especially the severe cases.Methods We analyzed the data including gender,age,time of onset,place of residence,contact history,clinical manifestation,accessory examinations and clinical outcome of 266　HFMD cases hospitalized in our department from Apr to Oct 2009,and identified the clinical and epidemiologic features associated with HFMD.Results Age group ranged from 4 months to 11 years with 87.6％(233/266) of the cases≤5 years.Most cases were resident in rural or suburban area,the number of which　was 3 times as much as urban.Neurological complications were more common,especially in the cases with increases of white blood cell and neutrophil number in peripheral blood.There were 40 cases with etiological examination results.Twelve cases were infected with enterovirus 71 ( EV71 ) and the others were infected with Coxsackievirus A16.Twelve cases with EV71 infection were complicated with meningoencephalitis,encephalitis,encephalomyelitis,one of whom was brain stem encephalitis.Conclusion The high-risk group of HFMD are the children less than 5 years.The suburban and rural are the key areas of prevention and control.The neurological complications are common,especially in the case with EV71 infection and significant increases of white blood cell and neutrophil number in peripheral blood.

Papers on reading population in domestic library and information field from 2002 to 2012 were retrieved.Its status quo, academic achievements and inadequacies were analyzed by bibliometrics and suggestions were put for-ward for reading population, such as further dividing its research subjects, strengthening its innovative research, and establishing its assessment system.

Clouston syndrome,also named hidrotic ectodermal dysplasia,is an autosomal dominant genetic disease.It is characterized by hypotrichosis,nail dystrophy and palmoplantar hyperkeratosis.It is caused by mutations in the GJB6 gene.Up to date,there are four GJB6 missense mutations that can cause Clouston syndrome:G1 1R,A88V,V37E and D50N.This article reviews the progress of gene diagnosis and pathogenic mechanism of Clouston syndrome,which can contribute to etiological diagnosis,genetic counseling,intervention as well as treatment.