150 slides of vaginal sample of married women aged 16-49 years old at 8 village of Ha Tay province were investigated. In 51.6% of subjects, there is not pathological manifestation in 48.3% - inflammative damages, then 38.6% with chronical manifestation and 12.6% with acute PaP1 account for 62.6%, PaP2: 24.5% and PaP3: 0.13%. There is not any cancerous damage. Hygiene condition, obstetrical history and venerological diseases were factors related to inflammative state and cervix cell morphology change
Women ; epidemiology ; Cervix Uteri ; cells

From 1996 to 2000, 73 samples of renal biopsy in patients >16 years old with glomerulonephritis and nephrotic syndrome were study on light microscopy. Results: the rate of minimal change glomerulopathy was highest (72.6%), then was the rate of diffuse mesangial proliferative glomerulonephritis (20.6%). The rates of focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, and membranous glomerulonephritis in this study were lower than the other studies. The changes in minimal change glomerulopathy are glomerular basement membrane thickened irregularly, widening and effacement of the visceral epithelial cell foot processes
Glomerulonephritis, Membranous ; Nephrotic Syndrome ; Patients

Surgical therapy should be the main method in treatment of rectal cancer.Along with the increase rate of undergoing anterior resection for rectal cancer,it is getting be paid more and more attention on postoperative anastomotic fistula as the main complications of rectal carcinoma.In recent research,anastomotic fistula occurred caused by various factors had also been put forward gradually,while the risk factors for postoperative anastomotic fistula were still remain unclear.Therefore,it is very important to understanding the risk factors in order to prevent the happening of the anastomotic fistula,and provide clinical basis for their necessary preventive colostomy.

Objective To study the correlation of blood gas analysis and diabetes mellitus in chronic obstructive pulmonary disease(COPD)patients and its clinical significance.Methods One hundred and twenty-five patients with stable phase COPD patients including 69 cages with COPD combined with diabetes mellitus(experimental group),56 patients with COPD alone(control group).The blood gas analysis and pulmonary function were detected.Results The simple pulmonary function forced vital capacity(FVC),vital capacity(VC),forced expired volume in one second(FEV1),peak expiratory flow (PEF)(25%-75%)and the diffusion function parameters diffusion capacity for carbon monoxide of the lung (DLCO),DLCO/PRED in control group were significantly higher than those in experimental group(P<0.05).Arterial partial pressure of oxygen(PaO2)was lower in experimental group than that in control group[(61.23±8.34)mm Hg(1 mm Hg=0.133 kPa)vs.(72.34±9.32)mm Hg,P<0.05],while there was no significant difference in partial pressure of carbon dioxide in artery(PaCO2)between two groups[(45.34±6.43)mm Hg vs.(44.89±4.98)mm Hg,P>0.05].Conclusion COPD combined with diabetes mellitus may lead to some damage in lung function and diffusion function,it should be noted in the clinieal treatment of reasonable adjustments in treatment.

Objective To investigate the effect of telmisartan on the plasma brain natriuretic peptide (BNP) in patients with permanent cardiac pacing.Methods According to the method of simple random numbers,106 patients with permanent cardiac pacing were randomly divided into study group and control group,with 53 cases in each group.All patients received implanted operation of permanent pacemaker.The study group was given telmisartan tablets,1 time a day,1 tablet each time,until the end of follow-up.The control group was given valsartan.The plasma BNP was measured by the immunofluorescent assay before administration and at the end of follow-up.In addition,left ventricular ejection fraction (LVEF) and cardiac index (CI) was determined by echocardiography.Results The plasma BNP in two groups was lower than 100 ng/L before administration.At the end of follow-up,the plasma BNP changed slightly in study group,but increased in control group,and the plasma BNP in control group was higher than that in study group [(105.67 ± 15.64) ng/L vs.(73.23 ± 10.56) ng/L],and there was significant difference (P ＜ 0.05).LVEF and CI was stable within the normal range before administration and at the end of follow-up in study group [(58 ± 4)％ vs.(59 ± 5)％,(3.58 ± 0.32) L/(min· m2) vs.(3.56 ± 0.26) L/(min· m2)].LVEF and CI at the end of follow-up in control group was decreased compared with that before administration[(49 ± 3)％ vs.(56 ± 3)％,(2.97 ± 0.26) L/(min· m2) vs.(3.62 ± 0.29) L/(min· m2)],which was lower than that in study group[(49 ± 3)％ vs.(59 ±5)％,(2.97 ±0.26) L/(min·m2) vs.(3.56 ±0.26) L/(min·m2)],and there was significant difference(P ＜ 0.05).Conclusions Telmisartan can delay the increase of the plasma BNP in patients with permanent cardiac pacing,delay the onset of symptoms of heart failure,and improve the quality of life.So early administration of telmisartan is recommended for the patients with permanent cardiac pacing.

Objective To investigate the clinical effect of low molecular weight heparin calcium combined with urease on intravenous thrombolytic therapy for myocardial infarction,and evaluate its safety.Methods One hundred and seven patients diagnosed myocardial infarction were randomly divided into the observation group (n =54) and control group (n =53),who were hospitalized in Yantai Central Hospital from January 2011 to December 2012.Patients in control group were given regular treatment plus basic support treatment for the symptomatic.Patients in the observation group were treated intravenous thrombolysis,subcutaneous low molecular weight heparin besides the basic treatment,10 d as a course of treatment.Observed the therapeutic effect in patients,observed and evaluated the safety of using two drugs in combination therapy group.Results (1) The recanalization rate of coronary artery in observation group was 83.33％ (45/54),higher than that in the control group (60.38％ (32/53),x2 =4.296 ; P ＜ 0.05).(2) The time of ST-T dropped back to 50％ in the observation group was (2.0 ±0.6) h,and recanalization time was (1.3 ±0.4) h,less than that in the control group (3.4 ± 0.5) h,(2.1 ± 0.3) h respectively),and the difference were significant (t =2.948,P ＜0.05 ; t =3.186,P ＜ 0.05).(3) Incidence of complications in the observation group was 44.44％ (24/54),significantly less than that of the control group (77.36％ (41/53) ; x2 =3.918,P ＜ 0.05).Two cases of the observation group were with reinfarction,accounting for 3.70％ and 9 cases in the control accounting for 16.98％.The difference was statistically significance (x2 =4.142 ; P ＜ 0.05).Conclusion The therapy plan of low molecular heparin combined with urease intravenous thrombolytic therapy for myocardial infarction can significantly improve the clinical effect of patients,reduce the complications and the incidence of myocardial infarction.It was proved as a safe and effective therapy plan in improving the prognosis of patients.

Objective To appraise the value of combined multiple tumor markers in the diagnosis of ovarian tumors. Methods Eighty-three patients with ovarian tumors confirmed by pathological diagnosis were tested with combined multiple tumor markers including CA125,CA19-9,alpha-fetoprotein (AFP),carcinoembryonic antigen (CEA), serum ferritin (FT) preoperatively by automated chemiluminescence assay,and the relations between the results and the pathological diagnosis were analyzed retrospectively.Results There was statistical difference among the positive rates of tumor markers in malignant [ 83.87%(26/31 ) ] and benign ovarian tumors [ 36.54% (19/52) ] (P ＜ 0.05 ). Every tumor marker had its sensitivity and specificity,but CA125 was the best marker of all. Its sensitivity was 74.2%, specificity was 55.8%,positive predictive value was 50.0% ,the specificity of CEA,AFP and FT was all 98.1%, the sensitivity of those was 16.1%, 3.2%, 16.1% respectively. When combined with the others,it could improve its specificity and positive predictive value,but the sensitivity declined greatly. Conclusion The accuracy of distinguishing the malignant from benign ovarian tumors is enhanced by combined multiple tumor markers testing.

Teaching quality is the basis of higher education.This article compared the results of teaching supervision and evaluation between campus and affiliated hospitals of Qiqihar Medical University in 2011.Differences were found out and corresponding strategies were proposed in order to improve the teaching quality and train high-quality talents.

Papers on reading population in domestic library and information field from 2002 to 2012 were retrieved.Its status quo, academic achievements and inadequacies were analyzed by bibliometrics and suggestions were put for-ward for reading population, such as further dividing its research subjects, strengthening its innovative research, and establishing its assessment system.

Clouston syndrome,also named hidrotic ectodermal dysplasia,is an autosomal dominant genetic disease.It is characterized by hypotrichosis,nail dystrophy and palmoplantar hyperkeratosis.It is caused by mutations in the GJB6 gene.Up to date,there are four GJB6 missense mutations that can cause Clouston syndrome:G1 1R,A88V,V37E and D50N.This article reviews the progress of gene diagnosis and pathogenic mechanism of Clouston syndrome,which can contribute to etiological diagnosis,genetic counseling,intervention as well as treatment.