Objective To investigate the blood pressure circadian rhythm in patients with IgA nephropathy by ambulatory blood pressure monitoring and explore its role in the disease progression. Methods A cross sectional study was carried out.Blood pressure rhythm was studied by ambulatory 24-hour monitoring with a portable oscillometric recorder in selected patients with primary IgA nephropathy.The term dipper was described as blood pressure during night dropped at least 10％ below daytime blood pressure.The term non-dipper referred to those in whom the nocturnal decline in blood pressure was less than 10％.Clinicopathological indices between dipper and non-dipper groups were compared. Results Ninety-three patients completed ambulatory blood pressure monitoring among whom 68 (73％) patients were non-dipper.The frequency of non-dipper was 70％,70％ and 81％ in the patients at chronic kidney disease stage 1,2 and 3 or more.The frequency did not differ among these three group patients (P=-0.587).77％ of patients with hypertension and 69％ of patients with normotension were non-dipper (P=0.373).The disappearance of blood pressure circadian rhythm in IgA nephropathy was not influenced by age,gender,blood pressure,proteinuria,renal function and renal pathology lesions.Among the patients who were followed up regularly for more than 12 months (n=54),patients in the dipper group had a trend of slower eGFR decline rate than those in non-dipper group albeit the difference was not significant (P=0.329).Subgroup analysis revealed that in patients with hypertension and non-dipper (n=29),the eGFR decline rate was much faster than that in dipper group[(-6.79±11.58 )vs (-0.34±1.74) ml ·min-1 ·(1.73 m2)-1·year-1,P=0.019]. Conclusions Most patients with IgA nephropathy present disappearance of blood pressure circadian rhythm,even among those at an early stage or without hypertension.The loss of blood pressure rhythm may be associated with a rapid renal function decline rate in those with hypertension.

Objective To investigate the therapeutic effect of Jianpi Zengshi Granules(JZG) for children anorexia(CA),and to observe its effect on serum orexin,leptin and neuropeptide Y(NPY) levels.Methods Sixty anorexia children were equally randomized into two groups: the treatment group received JZG and the control group received Jianwei Xiaoshi Tablets.The treatment lasted 4 weeks.The therapeutic effect was evaluated after treatment,and the changes of serum orexin,leptin and NPY levels were observed before and after treatment.Results The comprehensive therapeutic effect,effect on TCM syndromes,and effect on symptoms and signs such as appetite,food in-take volume and body weight in the treatment group were superior to those in the control group(P

Objective To investigate the safety and effects of probiotics and oral scaling in the treatment of patients with chronic atrophic gastritis .Methods 180 patients with chronic atrophic gastritis were chosen as study objects.The patients were randomly divided into control group and research group according to the digital table ,with 90 cases in each group .The control group received sequential therapy and oral scaling ,the research group was given oral scaling combined with probiotics.After treatment for 3 months,the clinical effects,symptom score,pathology score,Hp clearing rate and adverse reaction between the two groups were compared.Results The total effective rate of the research group(92.22%) was higher than that of the control group (82.22%),the difference was statistically significant (χ2 =4.038,P<0.05).The gastric Hp eradication rate of the research group (96.67%) was higher than that of the control group(86.67%),the difference was statistically significant (χ2 =5.891,P<0.05).There was no statistically significant difference in positive rate of oral Hp between the two groups (P>0.05).Before treatment,the symptom score and pathology score between the two groups had no statistically significant differences (all P >0.05).After treatment,the symptom score and pathology score of the research group were ( 6.41 ±1.09 ) points, ( 5.46 ± 0.94)points,respectively,which were significantly lower than those of the control group [(7.56 ±1.18) points, (8.12 ±1.04) points],the differences were statistically significant (t =8.026,9.843,all P <0.05).7 cases (7.78%) of adverse reaction occurred in the research group ,and 5 cases(5.56%) in the control group,the differ-ence was not statistically significant between the two groups (χ2 =0.357,P >0.05).Conclusion Probiotics combined with oral scaling on the basis of sequential therapy in the treatment of patients with chronic atrophic gastritis can effectively improve the Hp clearing rate and clinical symptom ,and with good effects and safety .