No abstract available.

No abstract available.

Maternal and feta! effects of anesthesia for 100 Cesarean sections, performed during the past two-and-half year period in this hospital, have been evaluated. It is emphasized that the selection of anesthetic agent and method should depend upon the physical status of the patients and the ability of both obstetrician and anesthesiologists.
Anesthesia ; Cesarean Section ; Female ; Humans ; Pregnancy

BACKGROUND/AIMS: Transforming growth factor-a(TGF-a) is a polypeptide cytokine related to cell proliferation and transformation. TGF-a binds to EGF receptor and stimulating DNA synthesis in liver cell. The hepatitis B virus (HBV) by itself is also believed to play a role in the hepatic carcinogenesis. Recently, it was reported that TGF-a and HBV were synergistic in action with rapid appearance of hepatocelluar carcinoma in bitransgenic mice. Although TGF- a is thought to play an important role in hepatocarcinogenesis, its expression during the natural history of HBV hepatitis was poorly understood. This investigation was performed to elucidate the dynamic changes and istinct immunohistochemical staining patterns in the course of chronic HBV hepatitis with specific reference to hepatocelluar carcinoma and to explain the role of TGF-a in the pathogenesis of hepatocelluar carcinoma. MATERIALS/METHODS: Employing TGF-a monoclonal antibody, signal detection was carried out by peroxidase-conjugated streptavidin in deparaffinized liver tissue sections taken from HBsAg positive patients. All of the liver tissue sections were proven HBV DNA positive by in situ hybridization. Immunohistochemical staining was performed in the tissue sections obtained from four normal controls, six from patients with chronic persistent hepatitis, five with chronic active hepatitis, eight with liver cirrhosis and eleven with hepatocellular carcinoma. RESULTS: The patterns of TGF-a immunoreactivity were cytoplasmic-grain types in normal controls and chronic persistent hepatitis, honeycomb types in chronic active hepatitis, occasional cytoplasmic-flooding types in liver cirrhosis, and cytoplasmic-grape types in hepatocellular carcinoma. A Shapiro-Wilk W test for frequency table analysis for the expression of TGF-a in these different disease groups was statistically significant. CONCLUSION: These data suggest that step-wise distinct expression of TGF-a enhancement in HBV associated chranic liver diseases which eventually resulted in the development of hepatocellular carcinoma were conceivably due to dysregulation of liver cell cycles by both HBV and TGF-a during the persistent repetition of cell cycles.
Animals ; Carcinogenesis ; Carcinoma, Hepatocellular* ; Cell Cycle ; Cell Proliferation ; DNA ; Hepatitis ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis, Chronic* ; Humans ; In Situ Hybridization ; Liver Cirrhosis* ; Liver Diseases ; Liver* ; Mice ; Natural History ; Receptor, Epidermal Growth Factor ; Streptavidin

To two patients suffering from intractable upper abdominal pain associated with recurrent carcinomatosis following previous gastrectcmy, 10 per cent saline solution was administered through an indwelling epidural (T 7-8) catheter. The results are as follows: 1) The method effectively relieved the pain in both patients. 2) The durations of pain relief were variable. It is noteworthy, however, that the method is. remarkably effective in relieving intractable pain associated with incurable malignancies. 3) The pain accompanying saline injection could be modified by prior administration of xylocaine through the same catheter. 4) The method was simple without complications, hence ambulatory application was possible.
Abdominal Pain ; Carcinoma ; Catheters ; Humans ; Lidocaine ; Methods ; Pain, Intractable* ; Sodium Chloride

No abstract available.
Lung*

Focal cerebral ischemia was made in 20 adult cats by transorbital middle cerebral artery occlusion (MCAO) under pentobarbital anesthesia. Arterial blood gas, systemic arterial blood pressure (SABP), intracranial pressure (ICP), and regional cerebral blood flow (rCBF) on ectosylvian, suprasylvian, and marginal gyrus of the left hemisphere by hydrogen clearance were measured for 30 minutes before and 120 minutes after middle cerebral artery occlusion. Ten animals were treated with 20 mg/kg of pentoxifylline (PTF) and ten animals with 1ml/kg of normal saline as the control group for 30 minutes before and 30 minutes after middle cerebral artery occlusion. There was no beneficial effect of pentoxifylline (Trental(R)) on basal blood flow over left hemisphere before middle cerebral artery occlusion. Regional cerebral blood flow was highly significantly improved on the marginal gyrus (MG) for 90 minutes after middle cerebral artery occlusion, more remarkable for initial 60 minutes (P<0.01), and also significantly restored on suprasylvian gyrus (SSG) for initial 60 minutes by pentoxifylline (P<0.05). However, pentoxifylline failed to improve regional cerebral flow on extosylvian gyrus (ESG) which was considered dense core of infarct area due to middle cerebral artery occlusion in cat. In addition, pentoxifylline had significant hypotensive effect during intravenous administration for 60 minutes (P<0.05). These findings suggest the possibility of pentoxifylline to ameliorate hemorheological property rather than vasodilating effect in the collaterally perfused area around dense infarct.
Administration, Intravenous ; Adult ; Anesthesia ; Animals ; Arterial Pressure ; Brain Ischemia ; Cats ; Cerebral Infarction* ; Hemorheology ; Humans ; Hydrogen ; Infarction, Middle Cerebral Artery ; Intracranial Pressure ; Pentobarbital ; Pentoxifylline*

Intracranial arteriosclerotic aneurysm is most common in the basilar artery territories, in the old age group. Recently we have experienced a case of fusiform aneurysm of distal branch of middle cerebral artery in a 23 year old soldier. Surgical biopsy revealed it to be arteriosclerotic origin. And arteriosclerotic aneurysm in the young age seems extremely rare, but it seems also worthwhile bearing in mind of that possibility in young aneurysmal patients.
Aneurysm* ; Basilar Artery ; Biopsy ; Humans ; Middle Cerebral Artery* ; Military Personnel ; Young Adult

No abstract available.
Humans* ; Lung Neoplasms* ; Lung*

No abstract available.
Humans* ; Idiopathic Pulmonary Fibrosis*