1.THE EFFECT OF RAPEPOLLEN ON SERUM CHOLESTEROL, TRIGLYCERIDE AND FATTY ACID LEVELS IN RATS
Acta Nutrimenta Sinica 1956;0(03):-
The effect of rapepollen on the level of serum cholesterol, triglyceride and fatty acids were investigated experimentally in rats. Results revealed that the rapepollen had potencies to lower cholesterol and triglyceride and alter the composition of serum fatty acids such as decreasing oleic acid and increasing archidonic acid in the rapepollen fed group as compared with control.
2.Mechanism of intravenous procaine analgesia
Yong BAI ; Dajian XIE ; Xiaohua HU
Chinese Journal of Anesthesiology 1995;0(12):-
Objective:To investigate the mechanism of intravenous procaine analgesia. Method: Six adult patients, ASA grade Ⅰ-Ⅱ, scheduled for abdominal surgery were investigated. Anesthesia was induced with intravenous fentanyl and propofol. Endotracheal intubation was facilitated with vecuronium. Anesthesia was maintained with continuous intravenous infusion of procaine(1mg?kg~(-1)?min~(-1))and inhalation of isoflurane. All patients were artifically ventilated with 100% O_2. Cerebrospinal fluid(CSF)and plasma concentrations of procaine were measured with gascbromatography 10,20,30 and 60 min following initiation of the constant infusion of procaine,at 5th, 15th, 30th and 60th min after the discontinuation. Result: Plasma steady-state levels were achieved within 30 min after commencement of the continuous infusion of procaine, The mean plasma steady-state level was 14.8?2.95?g/ml. Fifteen min after discontinuing the procaine infusion, 78% of plasma procaine content was eliminated. CSF steady-stale level was not achieved until 15 min after discontinuing the procaine infusion. The mean CSF steady state level was 4.47?0.94?g/ml. The elimination of the procaine in CSF was quite slow,and at 60th min after discontinuing the infusion,the mean CSF procaine level was 1.85?0.19?g/ml. Conclusion: The delayed total subarachnoid blockade induced by procaine infusion may be the mechanism of intravenous procaine analgesia.
3.Swelling property of common hydrophilic polymers and their use in push-pull osmotic-pump tablets.
Wenping WANG ; Xiuqiong XIE ; Dajian YANG ; Xinzi CHEN
China Journal of Chinese Materia Medica 2009;34(18):2319-2321
OBJECTIVETo investigate the feasibility of swelling hydrogel instead of polyethylene oxide as swelling polymer in push-layer of push-pull osmotically controlled-release tablets.
METHODThe swelling patterns of tablets made of pure polymers were studied by immerging the tablets into purified water and testing their size at different time points. The push-pull osmotic-pump tablets were prepared and their release patterns in vitro were studied and compared by their similar factor (f2).
RESULTTablets with different swelling materials all showed satisfying release pattern in vitro and their release ratio at 12 h were all above 80%.
CONCLUSIONWith its release rate and cumulative release percentage at 12 h, the mixture of HPMC K15M and CMCNa in ratio of 1:1 is the best choice instead of polyethylene oxide as swelling polymer in push-layer.
Chemistry, Pharmaceutical ; Drug Carriers ; chemistry ; Osmosis ; Polymers ; chemistry ; Tablets ; Water ; chemistry