Objective:To observe the effect of orbital implant shrink range on the stress distribution in bone-implant interface. Methods:The 3D finite element analysis of craniofacial and orbital implant models with the implant length of 3,4,6 and 10 mm,and with the shrink range of0.05,0.1 and 0.15 mm were established respectively.The stress in the bone-implant interface were calculat-ed and analyzed.Results:The stress increased with the increase of implant shrink range.The stress produced by the implant with 0.15 mm shrink range decreased.The stress of the implant of 10 mm was lower than that of other implants with the shrink range of 0.1 and 0.15 mm.Conclusion:The maximal implant shrink range of 0.1 mm in the model can meet the clinical requirements in orbital implant planning.

AIM: To investigate the effects of Astragalus polysacharin(APS) on human fibroblast and human umbilical vein endothelia cell (HUVEC) proliferation, as well as its acts on adhesion between white cells and HUVECs. METHODS: Human fibroblasts from distal and proximal skin away the ulcer were cultured as normal fibroblasts(NF) and wounded fibroblasts(WF). MTT assay was used for detecting cell proliferation, Rose Bengal staining and fluorescence immunohistology assay were used for examining the adhesion of human polymorpho-nuclear cell(PMN) and TPH-1 to HUVECs. RESULTS: 2 44-156 mg/L APS promoted WF proliferation, and 2 44-39 mg/L APS also promoted NF proliferation, but it did not show any proliferating effect on HUVECs. APS inhibited the adhesion of PMN or TPH-1 to HUVECs induced by tumor necrosis factor(TNF). At 25-100 mg/L, it also inhibited both VCAM-1 and ICAM-1 expression in HUVECs induced by TNF. Treatment with APS for 12 h also inhibited CD44 expression in HUVECs. CONCLUSION: APS shows mitogenic activity on both human normal and wounded fibroblasts. It also exerts anti-inflammation effects by inhibiting adhesion molecule expression and adhesion of white cells to HUVECs. [

OBJECTIVETo assess the effects of 1-step method of changing the buccal position of the transported bone after distraction on early bone formation.

METHODSThe custom-made bidirectional distraction devices were used. Total of 8 adult mongrel dogs were procured. The bilaterally mandible premolars were extracted. After 1 month, the complete osteotomy was performed and the devices were placed. The gradual distraction was started after 1 week latency at the rate of 1 mm per day, total 6 mm in height was achieved. The 1-step method of changing the buccal position of the transported bone was performed the day after the vertical distraction period in one side of the animals, and the other side as the controlled side. All animals were killed after a 7 days consolidation. The vascular system was stained post mortem carbon ink perfusion to assess possible damages. Quantitative evaluations of bone density were performed with dual-energy X-ray absorptiometry (DEXA), analysis of the ratio of vascular square was conducted in a computer.

RESULTSAll animals tolerated the procedures well. After vertical distraction, the tested side can be moved 3 mm in buccal direction. DEXA examination showed that the density of the distracted bone was no statistical difference in both the tested and the controlled side. Vascular damage was not observed, and there was no statistical difference in the ratio of vascular square by analyzing the histological section in computer.

CONCLUSIONIn some extent, 1-step method of changing the buccal position of the transported bone after distraction can mold the regenerate bone to correct the axial displacement, without endangering early callus formation and vascularization.

Objective:To review the current research and existing problems of symptom cluster sentinel symptoms in cancer patients both domestically and internationally, so as to provide reference for future research.Methods:The literature on sentinel symptoms of cancer symptom clusters, from the establishment of the database until November 8, 2023, was electronically searched on platforms such as China National Knowledge Infrastructure, WanFang Data, VIP, China Biomedical Database, PubMed, Web of Science, Cochrane Library, Embase and so on. Descriptive statistical analysis was conducted.Results:Sixteen articles were included, with an overall upward trend in publication volume, including 10 Chinese articles and 6 English articles. The sentinel symptom hotspots of cancer patients' symptom clusters mainly included: (1) the number of symptoms included in the analyzed symptom clusters was 3 to 13, the number of symptom clusters was 1 to 8, and the number of sentinel symptoms explored in each literature was 1 to 8; (2) Identification and dynamic changes of sentinel symptoms in symptom clusters; (3) Differences in sentinel symptoms among different symptom groups of cancer patients; (4) Analyzing specific sentinel symptoms of symptom groups based on different statistical methods; (5) Intervention based on sentinel symptoms of symptom clusters.Conclusions:In recent years, the symptom cluster sentinel symptoms of cancer patients have received attention from researchers at home and abroad, but there are problems such as uneven development and inconsistent research methods. High quality identification research is needed to make the included population specific and the methods scientifically unified, and to focus on the impact and mechanism of symptom cluster sentinel symptoms on patient outcomes in symptom clusters, so as to investigate potential mechanisms and promote effective symptom management.

Objective To investigate the effect of preemptive analgesia on postoperative cognitive function in elderly patients with abdominal surgery .Methods Totals of 127 cases of elderly patients with open major surgery were randomly divided into two groups:the experimental group (63 cases) and the control group (64 cases).The patients underwent preemptive analgesia in the experimental group , while the control group underwent conventional analgesia .VAS and MMSE were used to compare their pain and cognitive function between two groups , and dosages of fentanyl and adverse reactions were also observed .Results There were finally 60 cases in each group who had finished the study .The pain score was ( 1.86 ±0.62 ) in the experimental group and (4.03 ±0.48) in the control group six hours after operation , with statistically significant difference (t=3.67,P<0.0).The score of cognitive function was (25.42 ±0.63) in the experimental group and (21.77 ±0.50) in the control group 24 hours after operation, and the difference was statistically significant (t=3.54,P<0.05).The dosages of fentanyl was (597.94 ±82.41) μg in the experimental group and (826.47 ±113.28) μgin the control group, with statistically significant difference (t=5.42,P<0.01).The incidence of POCD was 20.00%in the experimental group and 38.33%in the control group, and the difference was statistically significant (χ2 =3.03,P<0.05).Conclusions Preemptive analgesia of electroacupunctureon elderly patients with abdominal surgery can significantly reduce their postoperative pain and improve cognitive dysfunction .

To evaluate the clinical results of reconstruction orbital defect with craniomaxillofacial implant. Three patients with orbital defect were treated with ten implants. The magnetic abutments were attached six months after one stage operation and the prostheses were fabricated. Within 11 to 47 months of follow up, all implants were stable with successful osseointegration. The prosthesis fit the orbital defects well. Reconstruction of orbital defect with craniomaxillofacial implant can be considered as a viable alternative treatment.

As a traditional Chinese medicinal material， Citri Sarcodactylis Fructus is often used as medicine after steaming to reduce its pungency and give full play to its medicinal effects. By consulting the relevant literature， this paper intends to sort out the related researches on the processing history， modern processing standard records， flavor and meridian tropism， efficacy， processing and taking methods， processing technology， chemical composition， pharmacological effects and quality analysis of Citri Sarcodactylis Fructus. It is found that the processing methods of Citri Sarcodactylis Fructus in the past dynasties are mainly roasting， distilled into dew， aging， frying， salting and steaming， of which steaming is the most common. In modern times， steaming is mainly used in Guangdong and Sichuan. The descriptions of flavor and meridian tropism and efficacy of Citri Sarcodactylis Fructus in the past dynasties are basically consistent with the modern descriptions. Its taste is pungent， bitter and acidic， and it is warm in nature. It belongs to the liver， spleen， stomach and lung meridians. Citri Sarcodactylis Fructus contains volatile oil， flavonoids and their glycosides， coumarins and limonins and other compounds. In recent years， high performance liquid chromatography （HPLC）， gas chromatography-mass spectrometry （GC-MS） and ultra performance liquid chromatography-mass spectrometry （UPLC-MS） and other methods are commonly used for the chemical composition analysis. Citri Sarcodactylis Fructus has the activities of relieving cough， reducing phlegm， relieving asthma， anti-inflammation， anti-bacteria and anti-oxidation， etc. After processing， its volatile and non-volatile components， and pharmacological effects all have a certain change. However， the current research on processing of Citri Sarcodactylis Fructus is not in-depth enough. It is necessary to further analyze the material basis of steaming to reduce dryness， explore its dryness medicinal substances and dryness-effect quantitative correlation， so as to clarify its processing mechanism， and provide basis for the subsequent processing research， resource development and comprehensive application of Citri Sarcodactylis Fructus in the future.

Citri Reticulatae Pericarpium is a commonly used traditional Chinese medicine in China. By referring to herbal monographs and related research documents， and comparing all editions of Chinese Pharmacopoeia and local processing specifications， the processing history， modern processing specifications， study on chemical constituents and pharmacological effects before and after processing of Citri Reticulatae Pericarpium were summarized. It was found that the processing methods of Citri Reticulatae Pericarpium in the past dynasties were mainly cleansing， cutting and frying. The processing methods of Citri Reticulatae Pericarpium included in all editions of Chinese Pharmacopoeia were all cleansing and cutting. In modern local processing specifications， there were mainly processing methods such as frying， steaming and carbonizing. The components of Citri Reticulatae Pericarpium were mainly volatile oil and flavonoids. After processing， the total amount of volatile oil generally decreased， and the contents and compositions of volatile oil and flavonoids also changed. It may be the main reason for the difference of efficacy before and after processing. At present， the optimization of processing technology of Citri Reticulatae Pericarpium mainly focuses on steaming， processing with vinegar and baking. Pharmacological research on Citri Reticulatae Pericarpium mainly focuses on reducing blood lipid， relieving cough， relieving asthma and resolving phlegm， and inhibiting pulmonary fibrosis. The current research on the processing methods of Citri Reticulatae Pericarpium is not in-depth enough， the material basis of many processing methods has not been clarified， and the research on the efficacy before and after processing is not in-depth enough. Further research is needed to clarify the material basis and mechanism after the processing of Citri Reticulatae Pericarpium， so as to standardize the processing method and establish specific quality standards.