Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features of iron accumulation, lipid peroxidation, and involvement of various inhibitory antioxidant systems. In recent years, an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders. Therefore, understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies. This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis, embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (SLE), vitiligo, and dermatological ailments precipitated by ultraviolet (UV) exposure, and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.

Objective To analyze the change of serum lipids and homocysteine level in patients with ischemic cerebrovascular disease.Methods A total of 150 patients with ischemic cerebrovascular disease (ICVD) were selected as ICVD group,and the patients were divided into short-term cerebral ischemia (TIA) group and cerebral infarction group (CI) group.Another 35 healthy people were selected as control group.Blood lipid index and plasma homocysteine level were compared among 4 groups.Results There was significant difference of Hcy between ICVD group,TIA group,CI group and control group (P<0.05).There was no significant difference of folic acid among the four groups (P>0.05).There were no significant differences in TC,TG and HDL-C between ICVD group,TIA group,CI group and control group (P>0.05),but there was significant difference in LDL-C (P<0.05).There were no significant differences in ApoA1 and ApoB between ICVD group,TIA group,CI group and control group (P>0.05),and there was significant difference in Fg (P<0.05).Conclusion Periodic detections of serum Hcy and blood lip index has a great value in prevention and treatment of patients with ischemic cerebrovascular disease.

Objective To analyze the change of serum lipids and homocysteine level in patients with ischemic cerebrovascular disease.Methods A total of 150 patients with ischemic cerebrovascular disease (ICVD) were selected as ICVD group,and the patients were divided into short-term cerebral ischemia (TIA) group and cerebral infarction group (CI) group.Another 35 healthy people were selected as control group.Blood lipid index and plasma homocysteine level were compared among 4 groups.Results There was significant difference of Hcy between ICVD group,TIA group,CI group and control group (P<0.05).There was no significant difference of folic acid among the four groups (P>0.05).There were no significant differences in TC,TG and HDL-C between ICVD group,TIA group,CI group and control group (P>0.05),but there was significant difference in LDL-C (P<0.05).There were no significant differences in ApoA1 and ApoB between ICVD group,TIA group,CI group and control group (P>0.05),and there was significant difference in Fg (P<0.05).Conclusion Periodic detections of serum Hcy and blood lip index has a great value in prevention and treatment of patients with ischemic cerebrovascular disease.