Objective To assess the reproducibility of brain activation by functional MR imaging during electroacupuncture stimulation at PC6(neiguan).Methods Six healthy adult volunteers participated in three identical scan sessions during different interval time.Each scan session consists of two functional tasks,an electroacupuncture stimulation(2 Hz) at PC6 and a control task of simple finger tapping.The reproducibility of brain responses was analyzed in terms of the overlap ratio of active volume within sessions and the ICC of active signal intensity in ROIs.Results The Roverlap of the simple finger tapping task(34.24?9.49) was significantly higher than that of the electroacupuncture stimulation task(13.23?14.21).The range of ICC of ROIs in the simple finger tapping task(0.69-0.80) was significantly higher than that of the electroacupuncture stimulation task(0.18-0.68).The results above showed that the reliability of brain activation in the finger tapping task group was higher than that in the electroacupuncture stimulation task group.The active intensity of ROIs in the simple finger tapping task was significantly higher than that in the electroacupuncture stimulation task,indicating the signal to noise ratio of brain activation in the finger tapping task group was higher than that in the electroacupuncture stimulation task group.Conclusion In contrast to the relatively reliable activation evoked by the simple finger tapping task,the activation evoked by electroacupuncture stimulation task was much more variable.The main possible reason is that the relatively low signal to noise ratio of brain activation on fMRI and low sensitivity caused the lower reproducibility of electroacupuncture stimulation task.The group analysis in combination with the individual functional data may be utilized to improve the reproducibility of fMRI evoked by electroacupuncture stimulation at PC6(neiguan).

Objective To investigate the reasons of repeated hospitalizations in school-age children with diabetes,and to explore the related interventions.Methods Based on purposive sampling,three endocrinologists from a Children's Hospital in Tianjin and the family members of 10 school-age children with diabetes were recruited into the study. A semi-structured depth interview was used to investigate the influence factors of the participants' compliance,acquisition of diabetes knowledge,and children's self-management. Claizzi phenomenological seven-step analysis was used to analyze data.Results Both the environmental factors and participants' attitudes would affect their compliance. The reasons of repeated hospitalizations included:insufficient knowledge and awareness of diabetes;lack of public education and concern;poor diet-control after discharge from hospital,inaccurate dose.Conclusions Intensive public education can be implemented through the internet to improve both knowledge and awareness of diabetes. Related health education should be strengthened to the children patients and their caregivers.

BACKGROUND: Most of the patients with lung and (or) mediastinal occupying lesions are considered to be primary lung cancer clinically, and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly useful operation to obtain the tissue sample and get definitive diagnosis of pathological tissues. In the EBUS-TBNA process, cytological rapid on-site evaluation (C-ROSE) is a useful technology. The purpose of our study is to discuss the value of C-ROSE in the diagnosis of lung cancer by EBUS-TBNA sampling. METHODS: Retrospective analysis of 141 cases clinical data who were performed with EBUS-TBNA and suspected diagnosis primary lung cancer, which were found have mediastinal and (or) lung lesions (including the enlargement of the lymph nodes/mass) by computed tomography (CT). Among these patients, 81 patients were in the C-ROSE group and 60 patients were in the No C-ROSE group. The message of puncture and complication of EBUS-TBNA with or without C-ROSE were compared. At the same time, we analysis the sensitivity and specificity, positive predictive value, negative predictive value of C-ROSE combined with EBUS-TBNA in that of the diagnosis of lung cancer. RESULTS: We found no statistical difference of the needle passes between C-ROSE group and No C-ROSE group. But in C-ROSE group, specimen qualified rate and diagnostic yields were signicantly higher than No C-ROSE group (98.77% vs 90.00%, 88.89% vs 75.00%, P<0.05), the incidence of complications in the C-ROSE group was signicantly lower than that in the No C-ROSE group (1.23% vs 11.67%, P<0.05). The sensitivity, specificity, positive predictive value and negative predictive value of C-ROSE combined with EBUS-TBNA in the diagnosis of lung cancer are 92.21%, 100.00%, 100.00% and 40.00%. CONCLUSIONS EBUS-TBNA combined with C-ROSE can improve the specimen qualified rate and diagnostic rate, also can reduce the complications thus worthy of further promotion.
Endoscopic Ultrasound-Guided Fine Needle Aspiration ; methods ; Female ; Humans ; Lung Neoplasms ; pathology ; Male ; Middle Aged ; Retrospective Studies ; Time Factors