Objective Serum indicators of oxidative protein damage (OPD) were analyzed to explore the effect on renal MMP/TIMP system of OPD in diabetic nephropathy. Methods AOPP levels and PCO levels were measured by modified Witko-Sarsat's method and 2, 4-dinitrophenylhydrazine spectrophotometric method, expression of serum MMP-2 were determined by ELISA, and MMP-2 activity were detected by zymography . Results AOPP levels of group DN1, group DN2 were higher than those of group DM(78.23±19.30 vs 61.25±12.13,101.59±30.22 vs 61.25±12.13,F＝41.988,P＜0.01). PCO levels of group DN1 and group DN2 were higher than those of group DM (0.84±0.03 vs 0.66±0.02,1.05±0.05 vs 0.66±0.02,F＝205.763,P＜0.01). Pearson correlation analysis indicated AOPP and PCO were positively correlated with the expression (r＝0.460,0.480,P＜0.05) and activity (r＝0.385,0.560,P＜0.05) of serum MMP-2. Multiple stepwise regression analysis showed that AOPP and PCO were major influential factors of serum MMP-2 expression (P＜0.05,P＜0.01) and activity(P＜0.01,P＜0.05). Conclusions OPD might be involved in the imbalance of renal matrix metabolism, which was correlated with the development of diabetic nephropathy.

Objective To explore the role of coping styles and personalities in the etiology of Graves' disease (GD). Methods All participants (581 patients and 800 normal controls) completed the general information questionnaires,trait coping style questionnaires(TCSQ) and eysenck personality questionnaires revised,short scale for Chinese(EPQ-RSC). Basic characteristics of all subjects were documented, and logistic regression analysis was used to analyze the role of coping styles and personality in etiology of GD. Results The negative coping style(OR = 1.068,P=0.000) ,concealing character(OR = 1. 121, P=0.000) and internal and external personality (OR = 1.089, P = 0.005) neurotic personality (OR > 1.000, P< 0.05) were risk factors of GD( OR = 1. 162, P = 0.000) ,positive coping style was protective factor of GD( OR < 1.000, P<0.05). Conclusion Positive coping style and specific personality adjustment can prevent effectively onset of GD.