1.The Association Between Personality Traits and Decision Making in Young Male Adults With Depression
Dah Hyun KIM ; Yang Tae KIM ; Sung Won JUNG ; Ho Jun LEE
Journal of the Korean Society of Biological Therapies in Psychiatry 2023;29(1):9-19
Objectives:
This study was conducted to investigate the relationship between personality and decision making in the group of young male depression patients.
Methods:
Eighty-four male depression patients were subjected to the following test: Beck’s Depression Inventory-II (BDI-II), and Beck’s Anxiety Inventory (BAI), Korean Wechsler Adult Intelligence Scale-IV (K-WAIS-IV), Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Personality Assessment Inventory (PAI), Temperament Character Inventory-Revised Short version (TCI-RS), Delay Discounting Task (DDT), Game of Dice Task (GDT). Pearson’s correlation analysis was used to determine the association between DDT and GDT performance results and self-report examination. Multiple linear regression models were conducted to figure out the causal relationship between risky choice of GDT and the variables suspected of having a linear relationship. The collected data was analyzed using SPSS 21.
Results:
PAI mania, borderline features, dominance and novelty seeking of TCI-RS were positively correlated with the number of risky choices of GDT. Full Scale Intelligence Quotient, BDI-II, BAI score had no significant correlation with DDT and GDT. There was also no correlation between DDT and GDT.
Conclusions
The results suggest that risk taking decision is related to personality traits such as novelty seeking, while inter-temporal choice is not related to personality aspects. It could be inferred that two different decision-making processes take place independently at different brain regions.
2.Regulation of Stem Cell Fate by ROS-mediated Alteration of Metabolism.
Jung Min RYU ; Hyun Jik LEE ; Young Hyun JUNG ; Ki Hoon LEE ; Dah Ihm KIM ; Jeong Yeon KIM ; So Hee KO ; Gee Euhn CHOI ; Ing Ing CHAI ; Eun Ju SONG ; Ji Young OH ; Sei Jung LEE ; Ho Jae HAN
International Journal of Stem Cells 2015;8(1):24-35
Stem cells have attracted much attention due to their distinct features that support infinite self-renewal and differentiation into the cellular derivatives of three lineages. Recent studies have suggested that many stem cells both embryonic and adult stem cells reside in a specialized niche defined by hypoxic condition. In this respect, distinguishing functional differences arising from the oxygen concentration is important in understanding the nature of stem cells and in controlling stem cell fate for therapeutic purposes. ROS act as cellular signaling molecules involved in the propagation of signaling and the translation of environmental cues into cellular responses to maintain cellular homeostasis, which is mediated by the coordination of various cellular processes, and to adapt cellular activity to available bioenergetic sources. Thus, in this review, we describe the physiological role of ROS in stem cell fate and its effect on the metabolic regulation of stem cells.
Adult Stem Cells
;
Cues
;
Energy Metabolism
;
Glucose
;
Homeostasis
;
Metabolism*
;
Oxygen
;
Reactive Oxygen Species
;
Stem Cells*