Background: Wound healing mechanisms still unclear. Wounds are physical injuries that result in an opening or breaking of the skin. Proper healing of wounds is essential for the restoration of disrupted anatomical continuity and disturbed functional status of the skin. This is a product of the integrated response of several cell types to injury. Wound healing is a complex process that results in the contraction and closure of the wound and restoration of a functional barrier.Goal: The purpose of this study was to determine burn wound healing activity of Calvacin. Materials and Methods:We used in study as colored reaction thin layer chromatography (TLC) and UV-spectrophotometer methods to determine active compounds in the three component drug "Calvacin".In research were inducted 20 healthy white mice and 40 rats. Investigation was based and implemented at scientific research laboratory of Traditional Medical Science Technology and Production Corporation and Institute of Veterinary medicine of pathological laboratory. The study protocol was approved by the Ethics Committee of the Ministry of Health.Results:Results of the phytochemical investigations showed that contained in the new drug "Calvacin" determined the presence of bioactive substances such as flavonoids, saponin, tannin, curcuminoids, organic acids and minerals. Substance was absorbed 25.7% in 40 grade ethanol, 27.1% in 70 grade, 22.2% in 96 grade and 19.6% in sterile water. We was established quality quantities of Calvacin in the drug amount summary flavonoids 1% and determined by UV spectrophotometer method. Proceeding from the absorption maximum of the substances analyzed the wave length of detection was determined as 370nm. In the result of mineral study of the "Calvacin", Ca^2.3%, P-6.17%, K-5.58%Burn wound healing time is control group 35±0.1 days, on 26±0.1 day animals of Calvacin group, but animals of Vishinski's ointment group 33±0.1 (p<0.05).Conclusions:1. The phytochemical investigations contained in the "Calvacin" drug determined the presence of bioactive substances such as flavonoids, saponin, tannin, curcuminoids, organic acids and minerals.2. Calvacin preparation has less toxic and significantly stimulate experimentally induced wound contract.

Introduction: A number of risk factors predispose an individual to hepatic drug Thus, there is need to develop a effective hepatoprotective formulation which could reduces of such liver complications caused due to hepatotoxic agents etc. The present work was focused on the investigation of hepatoprotective activity of various herbal formulations “Adapton 6” containing aqueous as well as hepatoprotective crude drugs. The herbal drug ingredients of Astragalus membranaceae (Астрагала перепончатого), Rhaponticum cartamoides (левзеи), Rheum palmatum L (ревеня), Rosa cinnamomea (плоды шиповника), Crataegus sanguine Pall (боярышника) and Hippophae rhamnoides L (облепихи) Purpose: The present study aims to examine the effects of Hepatoprotective activity of multicomponent herbal drug “Adapton 6”Materials and Methods: The hepatoprotective effect was studied further in rats, using carbon tetrachloride (CC!4)-induced hepatotoxicity as in vivo model. The Hepatoprotective activity of “Adapton 6” were evaluated and compared statistically after inducing hepatotoxicity in rats by intraperitonally administration of carbon tetrachloride (CCL4) with olive oil 50% as a diluent in 3 times 1 day. The liver damage was confirmed by estimation of elevated levels of cytoplasmic enzymes Serum Glutamate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), serum bilirubin and malondialdehyde (MDA), hydroperoxides, glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT).Result: On intraperiteonally administration of CCl4 in dose of 100 mg/kg produced acute hepatic damage in positive control (carbon tetrachloride treated) when compared with normal control. In treats groups, formulations “Adapton 6” were administered simultaneously with CCl4. Estimated levels of enzymes SGOT, SGPT, SALP and bilirubin in test groups were compared with levels of enzymes in normal, control groups. These show hepatoprotection effect but other due to antioxidant effects like exist of malondi-aldehide and catalase (CAT) activities.Conclusion: On conclusion, the prepared multicomponent herbal drug “Adapton 6” has demonstrated a very good hepatoprotection against the CCl 4 induced liver damage.

Үе мөчний өвчин нь удаан явцтай ба урьдчилан сэргийлэх түүнчлэн тууштай эмчилгээ хийлгэхгүй бол хүндэрч хөдөлгөөний дутагдалд орох аюултай байдаг.Иймд өрний эмийн эмчилгээний зэрэгцээ хүний биед сөрөг нөлөө багатай ургамлын гаралтай эм бэлдмэл гарган авах, судлах ажил чухлаар шаардагдаж байна. Бид далан түрүү, урт навчит батраш, улаан чинжүүгээр найрсан үе мөчний бигнүүрийг судлагдахуун болгон авч эмнэл зүйн судалгааг УАШУТҮК-н амбулаториор эмчлүүлэхээр ирсэн 60 хүнд шавар эмчилгээтэй харüцуулан явууллаа. Судалгааны үр дүнд бигнүүр нь үрэвслийг дарахын зэрэгцээ хэсэг газрын үйлчлэлээрээ захын мэдрүүлүүдийг цочроож үений цусан хангамжинд нөлөөлж үрэвслийг дарах , өвдөлт намдаах, антиоксидант үйлдэл үзүүлдэг нь уг бигнүүрт агуулагдаж байгаа ургамлуудын биологийн идэвхит бодисуудын (флавоноид, кумарин, алкалоид, органик хүчил ) үйлчилгээг гаргаж чадаж байгааг баталж байна.

Background Module-hierarchical method of medicine preparation has been used widely in traditional medicine for the preparation of multi-compound medicine preparation. Aim of study This article aim to analyze traditional method of module-hierarchical of medicine preparation in prospect of theory and methodology of system as well as to determine its form and nature. Materials and methods Relevant sections of the book “Four principals of medicine” was used as a material in the research. Research was done by using reference index calculation method (Dagvatseren.B, 1996) that affects humors of the medicine (wind, bile, phlegm). Identification of diseases and the relationship between medicines was analyzed in accordance with the systematic general theory and methodology (Urmantsev.Yu.A., 1988). Results There are 8 groups of medicines in the powder and herbal medicines group of “Four principals of medicine” that were prepared by module-hierarchic: 1) Dignitary Gurgum-7, 2) Basic component Gabur, 3) Anar-Basic component, 4) Anar-4 basic component, 5) Dali-Basic component, 6) Compound of Garanz-6, 7) Herbal medicine which expel fever with a guide, 8) Herbal medicines which eliminate cold. Total of 124 recipes and compounds are included. . Medicines prepared by module-hierarch are divided into: 1. Vertical 2. Horizontal 3.Beveled or branched 4.Mixed type by its form of method.When calculating the reference index of affecting the mistakes of medicine of 124 medicines and compositions, reference index of 119 medicines are in accordance with their using instructions. But reference index of 5 recipes that were prepared by leading and single taste exceeded the limit of 0:1. Conclusions Recipes and composition of medicines prepared by module- hierarchic depends on relationship between organs and system, its crisis (loss), disease progress and classification. It will keep the systematic characterestics of traditional medicine and contains new independent theoretical and methodological approach that can be named as systematic traditional medicine, treatment and research of systematic traditional medicine.
Systematic medicine ; basic substances ; disease location and classification ; methods of compounding medicines made by module-hierarich

Introduction:Influenza A viruses (IAV) are important pathogens that cause acute diseases in humans and domestic animals. In Mongolia only during 2010/2011 influenza season, there has been registered in average 1232 influenza like illness per 10.000 people, which is 5.8% of all the registered outpatient visits. Scutellaria baicalensis Georgi is one of the most widely used Mongolian Traditional Medicine that historically is used in anti-inflammation, anticancer, antiviral and antibacterial therapy. The goal of this study was to study antiviral effectiveness of Scutellaria baicalensis Georgi extract on the cells via in vitro. Methods:Water extracts of Scutellaria baicalensis Georgi were prepared from its rhizomes and herbs. To assess the antiviral properties, avian influenza virus isolate A/H3/Teal/Tunka/7/2010 was incubated at 37°C for 30min in presence and absence of plants and the drug extracts in various concentrations. Subsequently the concentration of infectious virus in each sample was determined by plaque assays. Neutralisation indexes and 90% plaque reduction concentrations had been estimated for each extract and significance of data obtained was evaluated using convenient statisticalmethods. Results:The extracts of Scutellaria baicalensis Georgi no significant toxicity, is well tolerated by Madin-Darby canine kidney cells at concentrations up to 1-0.25%. The extracts of Scutellaria baicalensis Georgi reduced the titer of A/Teal/Tunka/7/2010 (H3N8) by 50% (p≤0.05). The plaque reduction neutralization tests revealed that none of the extracts tested were able to inhibit 90% of plaques. However, extract ofScutellaria baicalensis Georgi, is able to inhibit more than 50% of plaques at low dilutions from 1:3 to 1:14 and the former two were expressing concentration- dependent inhibitory effect. Conclusion 1.Antiviral action of the extracts of Scutellaria baicalensis Georgiis detected. These extracts significantly reduced the infectiveness ofinfluenza A virus H3N8 in-vitro when used in high concentrations (1-0.25%). 2.Extract of Scutellaria baicalensis Georgi is well tolerated by Madin-Darby canine kidney cells at concentrations up to 0.94%.

Introduction: Diabetes mellitus is a complex, progressive disease, which is accompanied by multiple cardiovascular complications. Oxidative stress is significantly increased in diabetic patients and may lead to great haemostatic disturbances existing in these patients. The major thrust was to review current literature on potential interrelationships between haemostatic and metabolic abnormalities in diabetes mellitus. Zomoshin-6 decoction and Caragana jubata (Fabaceace) used in traditional Mongolian medicine have been shown to have haemostatic and antiviral effects. Objectives: The aim of this study was to examine the effect of Caragana jubata (Pall.) Poir. and Zomoshin-6 decoction on haemostatic parameters and lipid profiles in diabetic rats. Methods: Diabetes was induced in rats by using alloxan at a dose of 150 mg/kg. Control group received distilled water. Caragana jubata (Pall.) Poir and Zomoshin-6 were administered orally at doses of 2.0 g/kg and 0.2 g/kg respectively. Aspirin (100mg/kg) was used for comparison as a standard medicine. All treatments were performed daily for 3 weeks. Blood samples were obtained and analyzed for fibrinogen levels, prothrombin time, triglycerides (TG) and plasma uric acid. Results and conclusions: Levels of TG (p<0.05), glucose (p<0.03) and plasma uric acid (p<0.02) were increased in rats administered alloxan compare to control and these were significantly reduced by Caragana jubata and Zomoshin-6 treatments (Table 1). Caragana jubata and Zomoshin-6 significantly reduced increases in fibrinogen (p<0.05) level and prothrombin time induced by alloxan (Table 2). Table 1. Effect of Caragana jubata (Pall.) Poir and Zomoshin-6 on alloxan-induced increase in levels in TG, uric acid, and glucose. Table 2. Effect of Caragana jubata (Pall.) Poir and Zomoshin-6 on levels of fibrinogen and prothrombin time in rats given alloxan Parameters Control Alloxan 150 mg/kg Alloxan 150 mg/kg Caragana jubata 2.0 g/kg Zomoshin-6 tan 0.2 g/kg Aspirin 100 mg/kg Triglycerde ( mg/dl) 80.9±2.9 139.1±1.7 57±1.8* 64.0±2.5* 75±1.7* Uric acid (mg/dl)1.3±0.4 2.82±0.9 0.85±0.1* 0.9±0.2** 1.1±0.6* Glucose (mg/dl) 110.3±2.8 140±11 99.2±5*** 135.5±22* 125.2±31* Control Alloxan 150 mg/kg Alloxan 150 mg/kg Caragana jubata 2.0 g/kg Zomoshin-6 0.2 g/kg Aspirin 100 mg/kg Fibrinogen (g/l)221.2±8.7 254±3.7 264.3±4.0* 207.4±3.5** 168.4±1.9** Prothrombin time (sec) 14.1±4.6 9.57±0.3* 22.7±2.3* 22.8±0.7** 20.5±3

Introduction: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder affecting multiple joints. Although etiology of RA is not fully understood, TNF-alpha has been shown to play a central role in the pathogenesis of RA. TNF-alpha stimulates proliferation of synovial cells and the production of matrix metalloproteinases by chondrocytes and synovial cells, and induces the release of other pro- inflammatory cytokines, leading to joint destruction. Objectives: The aim of the present study was to investigate the therapeutic effects of sunlavin, an arthritis relief tea on antigen- induced arthritis in rabbits. Methods: Arthritis of the knee joints was induced by ovalbumin injection into the joint spaces of pre-immunised rabbits. For time course experiments sunlavin was administered to rabbits for 7, 20, 34, and 49 days. Histopathological analysis of the synovial tissue was performed. Level of tumor necrosis factor-alpha (TNF-alpha), erythrocyte sedimentation rate (ESR), C reactive protein (CRP) level, and white blood cells count (WBC) were measured. Results: Sunlavin reduced joint swelling of antigen-induced arthritis model of rabbits. Histological examination revealed that sunlavin reduced edematous changes and infiltration of inflammatory cells in the synovial tissues. Increases in ESR, CRP, and WBC were reduced up to 52% by sunlavin. Moreover, sunlavin decreased blood level of TNF-alpha (21%) in rabbit model of antigen-induced arthritis suggesting that sunlavin ameliorates inflammatory response in arthritic joints by inhibiting THF-alpha. Discussions and conclusions: We speculate that the effect of sunlavin might be affected by the tissue environment and the disease state, that is, the effect of sunlavin on inflammation may change during the inflammatory process. Sunlavin can be a potential anti-inflammatory agent for acute and chronic phase of inflammation.