1.A Study on Arrenotokous Toxic Action of Diphenylmethane Diisocyanate and Its Mechanism
Jinpeng ZHOU ; Jie LI ; Dafeng LIN
Journal of Environment and Health 1992;0(02):-
Objective To evaluate the arrenotokous toxic action and the related mechanism of MDI in mature male KM mice. Methods The 8-month-old healthy KM mice were intraperitoneally injected with MDI maize oil solution at the dose of 0、62.5、125.0、250.0 mg/kg in normal control group and 3 experiment groups respectively for 14 days.The male mice were killed on day 15 for the measurement of the viscera coefficient of testis and epididymis, the sperm count in epididymis, the activities of enzymes of testis,and concentration of related hormone in testis and blood serum. Results There was no significant difference in body weight between the experiment and the control groups. The viscera coefficient of testis and epididymis in 250.0 mg/kg group decreased significantly compared with the control group(P
2.Clinical effect of the relative poking reduction for the treatment of the femoral neck fractures with insertion and forward angle.
China Journal of Orthopaedics and Traumatology 2016;29(11):1001-1004
OBJECTIVETo explore the reduction and clinical effect in the near future of percutaneous K-wire relative poking reduction techniques for difficult to reduction of complex insert and forward angulation femoral neck fracture.
METHODSThe clinical data of traumatic femoral neck fractures treated in our hospital from January 2012 to September 2015 were retrospective analysis, 15 patients with skeletal traction and distal elevation still can not eliminate the fracture angulation deformity were treated by percutaneous K-wire relative poking reduction technique to correct the angular and using cannulated screw fixation, including 5 males and 10 females, aged from 44 to 72 years with an average of 60.06 years old. The fractures were Garden type III. The reduction effect was evaluated according to Garden alignment index and clinical evaluation in the near future outcome was assessed according to Harris Hip Score.
RESULTSAll patients were healed by first intention without pulmonary infection and deep vein thrombosis. The patients were followed up for 6 months to 3 years, all the fractures healed, and 1 case had limited necrosis of the femoral head. According to Garden alignment index, 14 cases were level I reducation, and 1 case was level II. Limb shortening was 1 to 5 mm with an average of (2.73±1.37) mm. Functional evaluation according to Harris score standard, at the latest follow-up the average value of pain, function, deformity and joint activity were 42.1±2.5, 37.2±4.6, 3.2±0.5, 4.1±0.3, the total average value was 86.6±9.5;13 cases were excellent, 1 case was good, 1 case was poor.
CONCLUSIONSPercutaneous K-wire relative poking reduction technique to correct the difficult to reduction of complex insert and forward angulation of the femoral neck fracture is simple, repeatable, and achieve the precision of the reset;the effect of blood supply of the hip joint is small, which provides favorable conditions for fracture healing.
3.Hybrid external fixator combined with limited internal fixation for the treatment of high-energy tibial plateau fractures.
De-fu YANG ; Gong-lin ZHANG ; Ming ZHANG ; Li-ping XIA ; Ji-hua HE ; Jun-yang PENG
China Journal of Orthopaedics and Traumatology 2009;22(3):219-220
Adult
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Aged
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External Fixators
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Female
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Fracture Fixation, Internal
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methods
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Humans
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Male
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Middle Aged
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Tibial Fractures
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surgery
4.The causes and strategies for the postoperative shortening in distal radius fractures.
De-fu YANG ; Gong-lin ZHANG ; Li-ping XIA ; Yu HUI ; Jian-hua HUANG ; Jian-feng CHEN
China Journal of Orthopaedics and Traumatology 2010;23(8):581-584
OBJECTIVETo analyze the cause of the postoperative shortening in distal radius fractures and to find treatment strategies to enhance the reduction effect of distal radius fracture and long-term efficacy.
METHODSFrom June 2005 to January 2009, 46 patients with distal radius fractures were treated by surgical operation including 17 males and 29 females,ranging from 27 to 90 years old with an average age of 48 years. All fractures were reduced satisfactory with smooth articular surface. The postoperative radial shortening was analyzed.
RESULTSAll patients were followed-up for 6 to 24 months with an average of 14 months. Among them, 12 patients had radial shortening. The causes of postoperative radial shortening includes: (1) patients older than 60 years; (2) severe osteoporosis; (3) preoperative displacement and comminuted fractures; (4) inappropriate fixation methods; (5) inadequate bone graft; (6) premature load.
CONCLUSIONThe key points to enhance the treatment outcomes include precise judgement of the fracture type and bone quality, sufficient bone graft, firmly fixed after anatomical reduction and an appropriate plan for early loadless functional exercise. Traumatic arthritis may be avoided or delayed if the above-mentioned six causes can be taken into consideration or preventive measures can be taken.
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Bone Transplantation ; Female ; Follow-Up Studies ; Fracture Fixation ; Humans ; Male ; Middle Aged ; Osteoporosis ; etiology ; Postoperative Complications ; etiology ; therapy ; Radius ; pathology ; Radius Fractures ; surgery
5.Myocardial Protection Effect of Dexmedetomidine in Patients Undergoing Open-heart Surgery under CPB
Qiugu ZENG ; Dafeng LI ; Xiangru CEN ; Yiyou YANG ; Xianqin CHEN ; Baoliu LIN ; Yuexian TAN
Modern Hospital 2017;17(5):752-754
Objective To observe the myocardial protective effect of dexmedetomidine in patients undergoing open-heart surgery under cardiopulmonary bypass (CPB).Methods 50 patients of open-heart surgery under CPB were randomly divided into two groups equally, namely observation group and control group.Observation group was treated with injection of dexmedetomidine at 0.5 μg/kg for 15 min, and then maintained at 0.4 μg/kgoh.The control group was given equal volume of normal saline.Concentrations of IMA and cTnI were determined before anaesthesia (t0), after 30 minutes of CPB (t1) and after surgery (t2).Results IMA and cTnI concentrations of t1 and t2 in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Dexmedetomidine has obvious protective effect on myocardium, which can reduce open-heart surgery of patients with myocardial ischemia reperfusion injury (MIRI).
6.Physical fitness evaluation results among students in Yunnan Province in 2019
HUANG Dafeng, CHANG Litao,HUANG Xin, DAI Limei, DENG Shuzhen, LI Wenwen, LI Yujie
Chinese Journal of School Health 2023;44(3):403-406
Objective:
To analyze physical fitness of students aged 6-22 years old from seven ethnic groups in Yunnan Province, and to provide reference for physical fitness intervention measures.
Methods:
The nationality, gender, grade, body shape, vital capacity, exercise quality of students were derived from the 2019 Yunnan Student Physical Health Survey Database. Comprehensive physical fitness score was calculated according to the National Student Physical Fitness Standards(revised in 2014). t test, ANOVA, and χ 2 test were used to analyze physical fitness score and level among students with different ethnic groups, gender, and school stages.
Results:
The average comprehensive score of physical fitness among students from 7 ethnic groups in Yunnan Province was (70.02±9.69), with the pass rate being 88.91%. The proportion of excellent was 0.93%, good was 17.90%, pass 70.09 %, and failed was 11.09%. Physical fitness score was highest in BMI (94.99 points), followed by 50 meter running (74.13 points), sitting forward bend (72.63 points), endurance running (70.43 points), standing long jump (67.77 points), sit ups ( 65.71 points) , 1 minute skipping rope (65.25 points), vital capacity (62.97 points), pull up (29.04 points). Physical fitness score and pass rate and evaluation level varied significantly by ethnicity and school stage( F =293.53,452.85, χ 2/ χ 2 trend =466.65, 412.57 ; 1 553.22 ,1 045.36, P <0.01).
Conclusion
The excellent rate of physical fitness among students in Yunnan Province is relatively low. Physical fitness promotion requires specific guidance and training based on ethnicity and school stage.
7.Effect of perioperative goal-directed fluid therapy on clinical outcome in elective colorectal resection.
Qiang LIN ; Huodong ZHOU ; Dafeng LI ; Jinfeng YE ; Jinfu HONG ; Yemao HU
Chinese Journal of Gastrointestinal Surgery 2015;18(7):671-675
OBJECTIVETo assess the effect of perioperative goal-directed fluid therapy (GDFT) on clinical outcomes in elective colorectal resection.
METHODSA total of 42 patients undergoing elective colorectal resection between March 2013 and December 2014 were recruited prospectively. GDFT was administrated based on corrected left ventricular ejection time and stroke volume using the esophageal Doppler monitoring. These patients were compared with a historical cohort of 58 patients managed without GDFT from January 2012 to February 2013. The primary endpoint was postoperative hospital stay and complication rate.
RESULTSThere was no significant difference in the overall fluid volumes administered intraoperatively between two groups [(2657±1037) ml vs. (2846±1444) ml, P>0.05], but patients in GDFT group received higher volume of colloid fluids [(935±556) ml vs. (688±414) ml, P<0.05]. After a period of concordance at the start of operation, corrected left ventricular ejection time, stroke volume and cardiac index increased in GDFT group compared with control group (all P<0.05). No significant differences were found in postoperative hospital stay [(11.27±6.42) d vs. (12.04±7.18) d, P>0.05] and total complication rate (26.5% vs. 25.9%, P>0.05) between two groups, but GDFT group had earlier postoperative flatus [(3.52±0.84) d vs. (4.48±0.71) d, P<0.05] and faster tolerated diet [(5.92±1.18) d vs. (6.83±0.95) d, P<0.05].
CONCLUSIONSPatients undergoing elective colorectal resection do not benefit from intraoperative GDFT. Further studies should be carried out to investigate whether GDFT can be routinely used during colorectal resection.
Colectomy ; Elective Surgical Procedures ; Fluid Therapy ; Goals ; Humans ; Length of Stay ; Perioperative Care ; Postoperative Period ; Prospective Studies ; Stroke Volume ; Treatment Outcome
8.Determination of indiumin urine by inductively coupled plasma mass spectrometry.
Yiran LIN ; Juntao HE ; Xiaozuo XU ; Jiangwei YIN ; Liuzhuo ZHANG ; Dafeng LIN ; Zhimin LI ; Juan YI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2015;33(8):630-631
Humans
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Indium
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urine
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Mass Spectrometry
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methods
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Spectrum Analysis
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methods
9. Detection of HLA-B*13:01 gene by dual allele-specific real-time polymerase chain reaction in patients with trichlorethylene-induced dermatitis
Dafeng LIN ; Yanhua YANG ; Dianpeng WANG ; Peimao LI ; Zhimin ZHANG ; Yanfang ZHANG ; Xianqing HUANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2017;35(8):589-591
Objective:
To investigate the detection of a human leukocyte antigen-B (HLA-B) allele
10.Changes of axial length in primary and secondary school students in Yunnan and associated factors
XIAO Jie,SU Meihui,LI Peiqian,HUANG Dafeng,LI Xixi,MA Zixue,LUO Xiao,CHEN Maosen,HUANG Ying
Chinese Journal of School Health 2024;45(1):133-137
Objective:
To explore the pattern of change of axial length/curvatrue radius ratio (AL/CR) and associated factors in primary and secondary school students in Yunnan, so as to provide scientific basis and prospective guidance for early myopia intervention and control.
Methods:
A total of 685 students from grades 2 to 3 and grade 7 in 2 cities/counties in Yunnan Province were selected by multi stage stratified random cluster sampling method in 2020. All the participants were followed up twice with questionnaire of myopia related factors, uncorrected distance visual acuity, and refractive parameter measurement from October,2021 and March,2023,respectivelty. The distribution and change of AL/CR in different classes and groups were analyzed, and the influencing factos of AL/CR cumulative progression were explored using generalized linear model.
Results:
AL/CR ratio in primary school students was (2.95±0.09) at baseline, increased to (2.99±0.11) at the first follow up and (3.04±0.12) at the second follow up. AL/CR ratio in middle school students(3.08±0.13) at baseline, increased to (3.12±0.15) at the first follow up and (3.15±0.14) at the second follow up. The generalized linear model showed that after controlling for environmental factors, ethnicity ( β =-0.017) , cumulative progression of the SE ( β =-0.027) influenced the changes of AL/CR ratio among the primary school students, whereas the changes of AL/CR ratio were associated with baseline AL ( β =-0.005), baseline corneal curvatrue radius ( β =0.032) and cumulative progression of SE( β =-0.035) among middle school students ( P <0.05).
Conclusions
The AL/CR ratio of primary and secondary school students in Yunnan can be used to judge different refractive status types, but its variation is not only related to SE progression, but also affected by different ethnic groups and baseline ocular biological parameters. so the value of AL/CR application in assessing the progression of myopia needs to be further confirmed.