Multilobular tumor of bone detected in a 2.5-year-old male Pekingese dog is reported. Grossly, the neoplasm consisted of multiple, variably sized, gritty, grayish-white to yellow nodules separated by thick collagenous septa. Histologically, these nodules contained multiple lobules of irregularly shaped and sized islands of well-differentiated osteoid and cartilage, separated by anastomosing fibrovascular septa. Chondrocytes and osteocytes were observed in the lacunae and in more osseous islands in the lobule, respectively. These lobules were surrounded by mesenchymal spindle cells. Mitotic figures were not evident. The neoplastic pattern was consistent with that of a multilobular bone tumor. Diagnosis was based on gross and light microscopic findings. The cause of this neoplasm was not determined.
Animals ; Bone Neoplasms/pathology/surgery/*veterinary ; Dog Diseases/*pathology/surgery ; Dogs ; Histocytochemistry/veterinary ; Male ; Mandible/*pathology/surgery ; Osteosarcoma/pathology/surgery/*veterinary

A 7-year-old female Eurasian otter (Lutra lutra) at the Seoul Grand Park, Korea, died after displaying depression, anorexia, weight loss and rough skin for several days. At necropsy, a solitary friable round mass, which was approximately 12 x 9 x 5 cm and mottled dark red and yellow, was found bulging from the right hepatic lobe. Microscopically, the nonencapsulated, poorly circumscribed mass was composed of solid sheets of neoplastic hepatocytes. In addition, numerous small tan foci, ranging from 0.5 to 1.0 cm in diameter, were evenly scattered throughout the pancreatic tissue. These foci were found to be nonencapsulated, well-demarcated hyperplastic nodules of the exocrine pancreatic gland. We observed neither intrahepatic nor extrahepatic metastases. Based on the gross and microscopic changes, we diagnosed the animal as having a hepatocellular adenoma accompanied by exocrine pancreatic nodular hyperplasia.
Adenoma, Liver Cell/*pathology/*veterinary ; Animals ; Fatal Outcome ; Female ; Korea ; Liver Neoplasms/*pathology/*veterinary ; *Otters ; Pancreas, Exocrine/pathology

Ceftriaxone is a commonly used antibiotic due to some of its advantages. Reversible gallbladder (GB) sludge or stone has been reported after ceftriaxone therapy. Most of these patients have no symptom, but the GB sludge or stone can sometimes cause cholecystitis. We experienced two patients who had newly developed GB stones after ceftriaxone therapy for diverticulitis and pneumonia, and this resolved spontaneously 1 month after discontinuation of the drug. Awareness of this complication could help to prevent unnecessary cholecystectomy.
Ceftriaxone ; Cholecystectomy ; Cholecystitis ; Cholecystolithiasis ; Diverticulitis ; Gallbladder ; Gallstones ; Humans ; Pneumonia ; Sewage ; Young Adult

Two Whooper swan (Cygnus cygnus) died after suffering from pododermatitis, lethargy, and ataxia; necropsy was performed. Grossly, the liver was swollen and firm. The kidney and spleen were also enlarged and a pale tan color. On histopathologic examination with Congo red staining, amyloidosis was noted in liver, spleen, and kidney. In addition, marked osseous metaplasia was present in the liver. Based on these results, systemic amyloidosis involving liver, spleen, and kidney with osseous metaplasia in the liver was diagnosed. Study results indicate that an inflammatory reaction associated with pododermatitis had a role in the amyloidosis in this particular case.
Amyloidosis* ; Ataxia ; Congo Red ; Kidney ; Lethargy ; Liver ; Metaplasia ; Spleen ; Triacetoneamine-N-Oxyl

A female domestic ferret (Mustela putorius furo) presented to a veterinary clinic with a clinical history of anorexia and poor body condition. Due to gradual deterioration of the body condition, explorative laparotomy was performed. Diffusely, the mesentery was severely thickened and adhered with prominent mesenteric lymph nodes. A portion of the mesentery and mesenteric lymph nodes were biopsied and fixed. Microscopic analysis revealed severe pyogranulomatous peritonitis and lymphadenitis, but staining revealed no bacterial organisms. However, immunohistochemistry for feline coronavirus exhibited strong immunoreactivity, primarily in the macrophages. Based on these results, the case was diagnosed as ferret coronavirus infection.

A 15-year-old castrated mixed breed dog presented due to a 5-month history of cough and difficulty in ambulation. Necropsy showed multiple periosteal and intramedullary infiltrative masses in the appendicular skeleton. In addition, single and multiple neoplastic nodules were observed in several organs, including the lungs, liver, kidney, and heart. Microscopically, several skeletal neoplastic masses and nodules in the parenchymal organs revealed similar changes. The neoplastic cells were spindle- to polygonal-shaped with prominent osteoid production and occasional cartilaginous and bone formation. Based on the gross findings and histopathology results, the case was diagnosed as multicentric osteosarcoma with systemic metastases.
Adolescent ; Animals ; Cough ; Dogs* ; Heart ; Humans ; Kidney ; Liver ; Lung ; Neoplasm Metastasis* ; Osteogenesis ; Osteosarcoma* ; Skeleton ; Walking

Pericardial mesothelioma is a rare neoplasm in dogs. This report describes a case of pericardial mesothelioma in a 13-year-old Shih Tzu that presented with a clinical history of dyspnea. Hemorrhagic pericardial effusion and chylous pleural effusion with reactive mesothelial cells were identified by radiograph and cytology. Necropsy revealed multiple round nodules throughout the pericardium and regional lymph nodes in addition to chylothorax. Histopathology revealed invasive neoplasm on the pericardial surface with metastasis to the lymph nodes. The neoplastic cells were immunopositive to both cytokeratin and vimentin. Diagnosis of pericardial mesothelioma with regional lymph node metastasis was made.

Over the 42 month period from January 2003 to June2006, a total of 2,952 canine biopsy specimens werereceived from the Veterinary Medical Teaching Hospitalof Seoul National University and from veterinary practitionersacross the nation. Out of these, 748 (25.34%) cases werediagnosed as canine cutaneous tumors in the Departmentof Veterinary Pathology, College of Veterinary Medicine,Seoul National University, Korea. Thirty-eight differenttypes of cutaneous tumors were identified and categorizedinto epithelial and melanocytic tumors (56.95%), mesenchymaltumors (38.90%), and hematopoietic tumors (4.14%)located in the skin. Among these, 69.25% were benign and30.74% were malignant. The top ten most frequentlydiagnosed cutaneous tumors were epidermal and follicularcysts (12.70%), lipoma (11.36%), mast cell tumors (8.82%),cutaneous histiocytoma (7.49%), basal cell tumors (6.82%),sebaceous gland adenoma (6.68%), sebaceous glandhyperplasia (5.08%), hepatoid gland adenoma (3.61%),apocrine adenocarcinoma (3.07%), and fibroma (2.81%),in order of prevalence. They comprised 68.45% of allcutaneous tumors. These top ten cutaneous tumors weredistributed on the trunk (30.08%), head and neck(20.9%), extremities (19.14%), anal and perianal area(8.59%), and tail (3.91%). The age of the dogs with the tenmost frequent tumors had a mean age of 8.3 years, with arange of 2 months to 19 years. When all types of tumorswere considered together in the entire population, therewas no difference in incidence according to sex.
Animals ; Biopsy/veterinary ; Dog Diseases/epidemiology/*pathology ; Dogs ; Female ; Immunohistochemistry/veterinary ; Korea/epidemiology ; Male ; Prevalence ; Retrospective Studies ; Skin Neoplasms/epidemiology/pathology/*veterinary