No abstract available.
Intubation, Intratracheal*

Postoperative brain damage is one of most serious complications of cardiopulmonary bypass (CPB). To prevent brain damage during CPB, adequate cerebral perfusion for cerebral oxygen demand should be maintained. This study monitored jugular venous oxyhemoglobin saturation (SjO₂), which reflects the overall balance of cerebral oxygen supply and demand, intermittently in 10 patients undergoing cardiac surgery. At the initiation of CPB, in spite of a significant decrease in mean arterial pressure, SjO₂ did not change, and it was stable during the hypothermic period of CPB. But a significan reduction in SjO₂ was observed during the rewarming period, and SjO₂ had an inverse linear correlation with esophageal temperature. Furthermore, the percent decrease of SjO₂ was related to rewarming speed. Therefore, therapeutic approaches for SjO₂ desaturation include slower rewarming, increasing cerebral blood flow, decreasing the cerebral metabolic rate for oxygen, increasing oxygen content, and increasing perfusion flow rate.
Arterial Pressure ; Brain ; Cardiopulmonary Bypass ; Cerebrovascular Circulation ; Humans ; Oxygen ; Oxyhemoglobins* ; Perfusion ; Rewarming ; Thoracic Surgery

BACKGROUND: In previous our retrospective study, we concluded that administered fluid volume, duration of operation, operative procedures and anesthetic techniques were the major factors of postoperative urinary retention. However, the administered fluid volume, age, types and duration of the operation confined to hemorrhoidectomy was questioned as a precipitating factor. The high retention rate in spinal anesthesia is also questioned. METHODS: We investigated these possible precipitating factors of urinary retention in healthy patients (n=154) undergoing hemorrhoidectomy. The patients were randomly divided into three different anesthetic techniques: caudal (2% lidocaine 300 mg with 1 : 200,000 epinephrine), spinal (0.5% tetracaine 5 mg with epinephrine 0.1 mg or 5% lidocaine 40 mg) and general (enflurane, N2O, vecuronium). Urinary retentin was searched according to above factors following surgery. RESULTS: The overall urinary retention rate was 46.1%. The retention rate in patients with spinal anesthesia was higher than that in those with other anesthetic techniques (p<0.05). There was no significant difference between patients with lidocaine and tetracaine spinal anesthesia in urinary retention rate. The administered fluid volume in patients with urinary retention was significantly higher than that of patients without retention (p<0.05). Age, duration and types of hemorrhoidectomy did not significantly affect urinary retention rate. CONCLUSIONS: Restriction of fluid administration and avoidance of spinal anesthesia are necessary in reducing postoperative urinary retention following hemorrhoidectomy.
Anesthesia, Spinal ; Epinephrine ; Hemorrhoidectomy* ; Humans ; Lidocaine ; Precipitating Factors ; Retrospective Studies ; Surgical Procedures, Operative ; Tetracaine ; Urinary Retention*

BACKGROUND: This study examined hemodynamic variables, oxygen delivery, extraction, and consumption in response to acute progressive hypoxia and hypercarbia in the setting of apnea. METHODS: Apnea was induced in 9 healthy mongrel dogs by disconnecting animals from mechanical ventilation of 30 minutes with pure oxygen. Hemodynamic variables, oxygen transport, extraction, and consumption were rapidly and repeatedly measured using pulmonary arterial and arterial catheters until cardiac output was undetectable. RESULTS: The baseline PaO2, PaCO2, pH, base excess were 318 +/- 137 mm Hg, 36 +/- 3.5 mm Hg, 7.30 +/- 0.06, 6.81 +/- 2.65 mmol/l respectively. Hypercarbia and hypoxemia (76 +/- 33 mm Hg) was first noted at 1 and 4 minute respectively. Base excess was not changed. Indices of preload (PCWP and CVP) were increased early in the time course (p<0.05). In contrast, indices of afterload (SVR) increased later, just before cardiac decompensation began (p<0.05). No significant reduction of cardiac output, oxygen delivery, extraction, and consumption was detected just until abrupt cardiac decompensation started, 5 minute. CONCLUSIONS: These data suggest that the early increase in preload was primarily due to hypercarbia whereas the late increase in afterload was due to hypoxemia, but the main cause of acute cardiac decompensation was a critical decrease in arterial oxygen tension with some contribution of increased preload and afterload.
Animals ; Anoxia ; Apnea* ; Cardiac Output ; Catheters ; Dogs* ; Hemodynamics* ; Hydrogen-Ion Concentration ; Oxygen* ; Respiration, Artificial

Plasma cholinesterase was assayed during the period immediately following IV bolus injection of succinylcholine 1mg/kg to test the effect of succinylcholine on pseudocholinesterase activity. Twenty healthy adult patients scheduled for elective surgery were studied. The resutls were as follows: The mean value of pre-injection pseudocholinesterase activity was 1124.15 IU/L, and the activity following succinylcholin injection was 1159.55IU/L during fasciculation, 982.70 at 1 min, 936.60 at 3 min, 891.25 at 5 min, 926.80 at 7 min, 1015.45 at 10 min, and 1007.70 at 15 min. It was concluded that the tendency to increase pseuducholinesterase activity during fasciculation seems to be due to choline, the metabolite of succinylcholine, however the cause of the significant decrease in pseudocholinesterase activity after fasciculation is uncertain. The only suggested mechanism is due to the inhibition of pseudocholinesterase by succinylcholine and its metabolites.
Adult ; Choline ; Cholinesterases ; Fasciculation ; Humans ; Plasma ; Pseudocholinesterase ; Succinylcholine*

BACKGROUND: During laryngoscopy, force applied to the soft tissue are assumed to cause circulatory response. The aim of the study was to evaluate this circulatory response and to analyze the relationship between the intensity of the force and the magnitude of the associated circulatory responses. METHODS: Sixty-three healthy patients, aged 17 to 29 years, were randomly allocated to one of three groups according to the three different subjective forces applied intentionally. Subjects in group 1 received minimal force enough to stimulate circulatory response, but not enough to expose the glottis. Group 2 received the optimal force necessary to expose the glottic opening. Group 3 received excessive force to expose the glottic opening. The axial forces of the laryngoscope handle with a Macintosh blade were measured during a ten-second laryngoscopy, and peak force, mean force, and area under the curve were calculated. Then, arterial pressure and heart rate were recorded after the laryngoscopy at 30 seconds intervals for 3 minutes. The data was compared among groups and with the baseline post-induction values. RESULTS: No significant difference was found in heart rate and blood pressure at each interval among the three groups, with increasing arterial pressure and heart rate after the laryngoscopy. Blood pressure and heart rate were maintained high, being progressively higher in the groups receiving a higher force. CONCLUSIONS: We conclude that little association was found between the force and the magnitude of circulatory response although higher forces cause longer circulatory responses.
Arterial Pressure ; Blood Pressure ; Glottis ; Heart Rate ; Humans ; Intention ; Laryngoscopes ; Laryngoscopy*

BACKGROUND: During laryngoscopy, force applied to the soft tissue are assumed to cause circulatory response. The aim of the study was to evaluate this circulatory response and to analyze the relationship between the intensity of the force and the magnitude of the associated circulatory responses. METHODS: Sixty-three healthy patients, aged 17 to 29 years, were randomly allocated to one of three groups according to the three different subjective forces applied intentionally. Subjects in group 1 received minimal force enough to stimulate circulatory response, but not enough to expose the glottis. Group 2 received the optimal force necessary to expose the glottic opening. Group 3 received excessive force to expose the glottic opening. The axial forces of the laryngoscope handle with a Macintosh blade were measured during a ten-second laryngoscopy, and peak force, mean force, and area under the curve were calculated. Then, arterial pressure and heart rate were recorded after the laryngoscopy at 30 seconds intervals for 3 minutes. The data was compared among groups and with the baseline post-induction values. RESULTS: No significant difference was found in heart rate and blood pressure at each interval among the three groups, with increasing arterial pressure and heart rate after the laryngoscopy. Blood pressure and heart rate were maintained high, being progressively higher in the groups receiving a higher force. CONCLUSIONS: We conclude that little association was found between the force and the magnitude of circulatory response although higher forces cause longer circulatory responses.
Arterial Pressure ; Blood Pressure ; Glottis ; Heart Rate ; Humans ; Intention ; Laryngoscopes ; Laryngoscopy*

A total of 33 patients with infective endocarditis were observed in the Guro and Hye Hwa Hospitals of Korea University Between September, 1981 and Feb, 1987. Among thses patients four patients presented with heart murmur and heart failure and had vegetation like findings observed on the two dimensional echocardiography. But these patients did not have any fever or leukocytosis in the peripheral blood and the repeated blood cultures were negative. They showed the immunologic phenomena of infective endocarditis such as microscopic hematuria in 4 patients, rheumatoid factor in 3 patients, false positive VDRL in one patient. The serum complement was decreased in 2 patients in whom it was checked. We report these 4 patients because we think these patients might be in the clinical stage in which the infecting organism is spontaneously cleared but the immunologic sequelae are remained.
Complement System Proteins ; Echocardiography ; Endocarditis* ; Fever ; Heart Failure ; Heart Murmurs ; Hematuria ; Humans ; Korea ; Leukocytosis ; Rheumatoid Factor

BACKGROUND: Rocuronium is suitable for short operations and rapidly controlling the airway on account of its rapid onset and intermediate action. However, the intravenous administration of rocuronium can cause pain and withdrawal movement in children. This study evaluated the effect of diluting rocuronium from 10 mg/ml to 1 or 0.67 mg/ml with 0.9% NaCl on the withdrawal response associated with the intravenous administration of rocuronium with the intubation dose. METHODS: Ninety pediatric patients undergoing general anesthesia were randomized into one of three groups; Group OR (only rocuronium 0.6 mg/kg, n = 30), Group SR10 (rocuronium 0.6 mg/kg diluted with 0.9% NaCl to 1 mg/ml, n = 30), Group SR15 (rocuronium 0.6 mg/kg diluted with 0.9% NaCl to 0.67 mg/ml, n = 30). After the loss of consciousness by a thiopental sodium 5 mg/kg injection, the patients from each group received the 0.6 mg/kg premixed rocuronium, respectively. Patients' withdrawal response to the injection were graded using a 4-point scale (Grade 0, 1, 2, 3). RESULTS: The incidence and the intensity of the withdrawal response were significantly lower in the SR10 and SR15 groups than in the OR group (P < 0.05). In the SR15 group, the intensity of the withdrawal response was under grade 2 in all patients. CONCLUSIONS: Diluting rocuronium to 0.67 mg/ml is a simple and effective method for preventing withdrawal movements during an intravenous rocuronium injection.
Administration, Intravenous ; Anesthesia, General ; Child ; Humans ; Incidence ; Intubation ; Thiopental ; Unconsciousness

BACKGROUND: Lidocaine sprayed down the endotracheal tube (ETT) before extubation and during ETT removal was reported to prevent increases in blood pressure and heart rate during and after extubation. We hypothesized that lidocaine administered via this route would suppress the cough reflex associated with tracheal extubation. METHODS: Eighty-five patients requiring intubation in the supine position were studied. All patients received a standardized anesthetic protocol. At the end of surgery, the patients were randomly divided into three groups and given no drug (group 1-control), given 1 mg/kg 2% lidocaine sprayed down the ETT 5 minutes prior to extubation (group 2), or given intravenous lidocaine (IVL) 1 mg/kg 3 minutes prior to extubation (group 3). Extubation was performed when the patients met the criteria of extubation. Number of coughs was recorded from 5 minutes before until 5 minutes after extubation. Each value was compared among the three groups. RESULTS: Seventy-five patients completed this study (n = 25 for each group). The incidence of patients experiencing coughing was decreased in group 2 (P = 0.03), compared with group 3 or the control. Number of coughs per patient was significantly less in group 2 (P = 0.00). IVL did not significantly diminish the incidence or the amount of coughing compared with the control. CONCLUSIONS: Lidocaine sprayed down the ETT suppresses cough reflex and is more effective than IVL in blunting the cough reflex. This study indicates that lidocaine sprayed down the ETT has a topical anesthetic effect suppressing the cough reflex.
Airway Extubation ; Anesthetics ; Blood Pressure ; Cough* ; Heart Rate ; Humans ; Incidence ; Intubation ; Lidocaine* ; Reflex* ; Supine Position