No abstract available.
Appendicitis* ; Barium* ; Enema*

No abstract available.
Graft vs Host Disease*

No abstract available.
Blood Coagulation Factors* ; Plasma*

No abstract available.

PURPOSE: We investigated the effectiveness and safety of DA-3030 for prophylatic use in patients receiving chemotherapy for malignant disease. MATERIALS AND METHODS: Seventy cancer patients were randomized to receive chemotherapy alone (36 patients) or with DA-3030 administered (34 patients) after stratified block randomization according to chemotherapeutic regimen. DA-3030 was subcutaneously administered at the dose of 100 pg/m/day for 10 days from 24 hours after the completion of chemotherapy. RESULTS: Of the 70 enrolled patients, 62 patients were evaluable. The neutropenia (absolute neutrophil count [ANC] <1,000/mm) occurred in 9 of 32 (28.1%) of the DA-3030 group and 21 of 30 (90.0%) of the control group, giving relative risk for control group of 0.154 (95% confidence interval [CI], 0.05 to 0.45; p-0.0001). Severe neutropenia (ANC 500/mm') occurred in 4 of 32 (12.5%) of the DA-3030 group and in 20 of 30 (66.7%) of the control group (relative risk for control group of 0.316 [95% CI, 0,18 to 0.55]; p=0.0001). The mean duration of neutropenic period (+/-standard error) was 1.13+/-0.34 days in the DA-3030 group and 6.73+/-0.69 days in the control group respectively, and was significantly shorter in the DA-3030 group (p<0.0001). And, there was higher nadir ANC in the OA-3030 group than that in the control group (p=0.0001); the mean nadir ANC was 2,547+/- 343/mm and 442+/-120/mm, respectively. The DA-3030 group had significantly higher incidence of myalgia in comparison to the control group (43.8% compared with 3.3%; p=0.001). However, it was tolerable and was easily managed by conservative therapy CONCLUSION: The use of DA-3030 was effective in preventing chemotherapy-induced neutropenia.
Drug Therapy* ; Humans ; Incidence ; Myalgia ; Neutropenia* ; Neutrophils ; Random Allocation

Idiopathic midline destructive disease(IMDD) is a subgroup of midline granuloma syndrome, which is a clinical entity characterized by a relentless uilcer ation of the upper air way involving the nose, the palate, and the face, with a fatal outcorne. A 32 year-old male had symptoms of nasal obstruct.ion and rhinorrhea for about 4 months prior to visiting the hospital ad was referred to our Department for evaluation of a verely destruct.ive skin lesions on his face. The patient, revealed unique clinopatholcgic featurs compat with IMDD. These were : 1) prescence of locally destructive lesion which were restricted to the upper respiratory tract. 2) abscence of systemic disease durin the follow up peroid, 3) The histologic features consisted of acute and chronic inflarnmation with a variable dearel of necrosis on the examination of repeated biopsy specimens, 4) inabiliy to demonst rate an infectious causative organisms on repeated laboratory tests.
Adult ; Biopsy ; Follow-Up Studies ; Granuloma* ; Humans ; Male ; Necrosis ; Nose ; Palate ; Respiratory System ; Skin

Erythroplasia of Queyrat is an uncommon form of carcinoma in situ involving the glans penis and adjacent mucosal structures. Treatment modalities of Erythroplasia of Queyrat vary widely and topical 5-fluorouracil treatment is very effective and regarded as the choice of t eatment. This article reports a case of erythroplasia of Queyrat involving the perimeatal region of the glans penis and identifies the difficulty of effectively treating erythroplasia of Queyrat which is adjaer to the urethral meatus with 5-fluorouracil and usefulness of electron beam irradiation therapy.
Carcinoma in Situ ; Erythroplasia* ; Fluorouracil ; Male ; Penis*

A total of 33 patients with infective endocarditis were observed in the Guro and Hye Hwa Hospitals of Korea University Between September, 1981 and Feb, 1987. Among thses patients four patients presented with heart murmur and heart failure and had vegetation like findings observed on the two dimensional echocardiography. But these patients did not have any fever or leukocytosis in the peripheral blood and the repeated blood cultures were negative. They showed the immunologic phenomena of infective endocarditis such as microscopic hematuria in 4 patients, rheumatoid factor in 3 patients, false positive VDRL in one patient. The serum complement was decreased in 2 patients in whom it was checked. We report these 4 patients because we think these patients might be in the clinical stage in which the infecting organism is spontaneously cleared but the immunologic sequelae are remained.
Complement System Proteins ; Echocardiography ; Endocarditis* ; Fever ; Heart Failure ; Heart Murmurs ; Hematuria ; Humans ; Korea ; Leukocytosis ; Rheumatoid Factor

Hemangioma of the kidney is a relatively uncommon tumor, which is most commonly located in the tip of the papilla. This lesion is usually small and has been found incidentally at postmorten examination. About 200 cases of renal hemangioma have been reported since Virchow's original report in 1876. In renal hemangioma, cavernous hemangioma is the most common type. They can create diagnostic problem for the clinician and the radiologist. We experienced a case of renal cavernous hemangioma in the medulla of the upper pole. The patient was a twenty-seven-year-old male who had gross hematuria and right flank pain. A nephrectomy was performed. An ill-defined mass, 4.5x3.0x1.5 cm, was observed around the pelvis. Microscopically, the tumor mass was hemangioma of the cavernous type.
Male ; Humans ; Hemangioma

BACKGROUND: Porokeratosis is a rare disorder characterized by an abnormal keratinization. Five different clinical types have been described, however most reports are on a small scale and rest,ricted to a particular type. OBJECTIVE: We tried to distinguish clinical and histopathologi'cal feat.ures of each type of porokeratosis. Methods: All patients with porokeratosis visiting the Dermatological Department of Chonnam University Hospital were retrospectively reviewed and finally 79 patients were evaluated. RESULTS: Disseminated superficial actinic porokeratosis(DSAP) was most common it was present in 44 patients(56%). This was f'ollowed by the plaque type(28%), linear type(14%) and punctate type(2%). The:;oungest average age of onset was in the linear type at 13 years old (range 2-34 years old), and the oldest in DSAP which appeared in all patients after the age of 20. The plaque type was predominant in males 2.6 times rnore than in females. The predilection sites were the trunk in the plaque type, the unilateral lower limbs in the linear type and the face lower limbs in DSAP. 1tching was a complaint in 71% of DSAP and pain was in 14% of t.he plaque type. DSAP revealed a family history in 23% and a solar exacervation in 41%. Three cases of the plaque type t ad a malignant change. The average number of cornoid lamella per section was 1.8(ranging from one to seven). The height and invagination depth of cornoid lamellae were most prominent in the plaque type, and the le~ast in DSAP. Dysk(ratotic cells and vacuolar cell degenerat,ion in t.he underlying epidermis were most frequent in the plaque type. However dermal melanophage were present in DSAP. The Epidermis inside ring of:o~rnoid lamella was acanthotic chiefly in the plague type and atrophic chiefly in DSAP. CONCLUSION: These resuts demonstrate that each type of porokeratosis is somewhat, different in clinical and histopathological features.
Actins ; Adolescent ; Age of Onset ; Epidermis ; Female ; Humans ; Jeollanam-do ; Lower Extremity ; Male ; Plague ; Porokeratosis* ; Retrospective Studies