1.Progressive Muscular Dystrophy: A Case Report
Jun Seop JAHNG ; Sung Kwan HWANG ; Dae Young HAN
The Journal of the Korean Orthopaedic Association 1978;13(3):445-450
Progressive Muscular Dystrophy is a hereditary disorder characterized by progressive weakness and wasting of muscules. The etiology of muscular dystrophy is unknown, and no from of pharmacological treatment is considered effective. We report 2 cases of progressive muscular dystrophy occuring in a family, which were diagnosed by clinical findings, serum enzyme study and electromyography.
Electromyography
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Humans
;
Muscular Dystrophies
2.A Case of Surgically Corrected-Combined form of Total Anomalous Pulmonary Venous Return.
Dae Sung HWANG ; Sun Hwan CHO ; Jong Bum CHOI ; Hyang Suk YOON ; Soon Ho CHOI
Korean Circulation Journal 1992;22(3):473-478
Total anomalous pulmonary venous return(connection) is a congenital heart disease. Especially, the reports of the patients with double connections of all pulmonary veins were rare. An infant who underwent operation for total anomalous pulmonary venous return had double drainge of all pulmonary veins to both left vertical vein and anomalous descending vein. This second lesion was not diagnosed preoperatively, but in operative field. Operative treatments were performed by ligation of left vertical vein and central pulmonary vein-to-left atrium anastomosis without ligation of the descending anomalous vein. For these less common variants fo total anomalous pulmonary venous return,a more detailed and precise understanding of morphology can facilitate accurate surgical repair. And also, early detection of the disease is an another issue for a good prognosis.
Heart Defects, Congenital
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Humans
;
Infant
;
Ligation
;
Prognosis
;
Pulmonary Veins
;
Scimitar Syndrome*
;
Veins
3.The value of computerized axial tomography of the brain in children with central nervous system disorders.
Young Gyun LEE ; Dae Sung HWANG ; Kwang Soo OH ; Hyang Seuk YOON ; Jong Duck KIM
Journal of the Korean Pediatric Society 1991;34(10):1409-1416
No abstract available.
Brain*
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Central Nervous System Diseases*
;
Central Nervous System*
;
Child*
;
Humans
4.The value of computerized axial tomography of the brain in children with central nervous system disorders.
Young Gyun LEE ; Dae Sung HWANG ; Kwang Soo OH ; Hyang Seuk YOON ; Jong Duck KIM
Journal of the Korean Pediatric Society 1991;34(10):1409-1416
No abstract available.
Brain*
;
Central Nervous System Diseases*
;
Central Nervous System*
;
Child*
;
Humans
5.A Case of Tuberous Sclerosis.
Ju Kyeong LEE ; Kwang Soo HWANG ; Kyung Sook CHO ; Doo Sung MOON ; Chong Dae CHO
Journal of the Korean Pediatric Society 1985;28(5):514-517
No abstract available.
Tuberous Sclerosis*
6.Immunohistochemical study of inositol phospholipid-specific phospholipase C in the rat liver and kidney.
Dae Sung KIM ; Seung Jun HWANG ; Dong Ho KIM ; Young Suk SUH
Korean Journal of Anatomy 1993;26(1):103-115
No abstract available.
Animals
;
Inositol*
;
Kidney*
;
Liver*
;
Phospholipases*
;
Rats*
;
Type C Phospholipases*
7.An Analysis of the Results of the Treatment of the Resistant Clubfoot
Kwang Jin LEE ; Deuk Soo HWANG ; Sung Ile CHO ; Hung Dae SHIN ; Jun Kyu LEE
The Journal of the Korean Orthopaedic Association 1990;25(5):1470-1477
The Clufoot is still controversial in the etiology, the pathology, and the method of the treatment. Turco issued one stage posteromedial soft tissue release in 1971, which is still widely used. But the Turco's procedure is not satisfactory results in forefoot adduction and ankle motion. McKay and Simon were performed one stage complete subtalar soft tissue release and reported better results compared with those who had posteromedial release. So we performed Turco's posteromedial release with lateral release by Cincinnati incision in 12 patients (20 feet) and analysis the results from Oct. 1987 to Jul. 1989 at the department of orthopaedic surgery of CNUH. The results were as followings ; 1. The mean age of the patient at first examination was 1 year 9 months (range from at birth to 5 year 10 months) and the mean age at operation was 2 year 1 month (range from 4 months to 5 year 10 months). 2. The clinical results were excellent in 2 feet, good in 14 feet, fair in 3 feet and unsatisfactory in 1 foot. 3. The radiological results were satisfactory in 18 feet and unsatisfactory in 2 feet. 4. Forefoot adduction was corrected in 14 feet (70%) as normal range, 3 feet as acceptable, and 3 feet as unacceptable 10' over the normal range. 5. Two feet of hind foot overcorrection result was operation as McKay's method. 6. The Clincinnati incision was favorable to visulization and release of the posteromedial, anteromedial and posterolateral structure of the foot.
Ankle
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Clubfoot
;
Foot
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Humans
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Methods
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Parturition
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Pathology
;
Reference Values
8.Detection of Platelet-Specific Antibodies Employing Modified Antigen Capture ELISA(MACE).
Tae Hyun UM ; Kyou Sup HAN ; Dae Chul KIM ; Yoo Sung HWANG ; Doo Sung KIM ; Sang In KIM
Korean Journal of Blood Transfusion 1995;6(2):123-130
Widely used tests for the detection of platelet antibodies in Korea include platelet suspension immunofluorescence test(PSIFT), enzyme immunoassay and mixed passive hemagglutination(MPHA). In these tests, removal of HLA antigens from platelet are required to detect platelet-specific antibodies. Modified antigen capture ELISA(MACE) is known to be very sensitive for the detection of platelet-specific antibodies, in which specific platelet glycoprotein, captured by the monoclonal antibody is used as a target antigen. MACE is very useful for the detection of platelet-specific alloantibodies in neonatal alloimmune thrombocytopenia(NAIT) and posttransfusion purpura(PTP). We employed MACE in our laboratory, using AP2(anti-GPIIb/IIIa, monoclonal), #30 sera(anti-PlA1), 90-545 sera(anti-HLA-B51+52) and LYS sera(multispecific HLA antibodies). LYS sera had been used as our positive control( 1:120) in MPHA. Platelet from PIA1(+), HLA-B5 I, blood group O healthy male donor, gave positive result with #30 sera(1:40) and negative result with 90-545 sera in MACE. With LYS sera, MACE showed negative in 1:120, but positive in 1:20. So LYS sera was thought to contain strong multispecific HLA antibodies and relatively weak antibody(-ies) reacting with GPllb/Illa. Further studies employing different monoclonal antibodies, such as anti-GPIb/IX, -GPIa/Ila and -GPIV are under way.
Antibodies*
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Antibodies, Monoclonal
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Blood Platelets
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Fluorescent Antibody Technique
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Glycoproteins
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HLA Antigens
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Humans
;
Immunoenzyme Techniques
;
Isoantibodies
;
Korea
;
Male
;
Tissue Donors
9.The Rh(D) RBC Antigen Density Measurement by Flowcytometry.
Kap No LEE ; Chae Seung LIM ; Dae Chul KIM ; Young Kee KIM ; Doo Sung KIM ; Yoo Sung HWANG
Korean Journal of Blood Transfusion 1996;7(2):173-179
BACKGROUNDS: The Rh antigens are important m clinical practice. The classification of Rh phenotype is usually based on the antigen detection done by conventional serologic method, but it has many limitation such as delicate grading of antigen expression. Recently, Flowcytometry has been introduced in immunohematology to detect and quantitate cell bound immunoglobulins to assess blood cell antigens and related antibodies. So, we tried these method to detect Rh(D) antigen and measure its density and evaluated the possibility of clinical usage. MATERIALS AND METHODS: We performed a flowcytometric analysis for the expression of D antigen in D-positive, negative and weak D group in indirect immune fluorescence assay by using polyclonal antibodies. We measured the intensity of immunofluorescence as a degree of antigen density and analysed the difference of mean channel fluorescence value(MCF) among these groups. RESULTS: Weak D groups had the lower fluorescence than D-positive group, while D-negative sample showed the same fluorecence as negative ntrol. The difference of fluorescence intensity of D antigen between that of C antigen were not observed and were statistically insignificant. CONCLUSION: Flowcytometry appear to be a good tool for antigen density measurement in immunohematologic areas and shows the possibility of application to other aspect.
Antibodies
;
Blood Cells
;
Classification
;
Fluorescence
;
Fluorescent Antibody Technique
;
Immunoglobulins
;
Phenotype
10.Comparison of Context-Sensitive Half-Time from PK-SIM Computer Simulation with Duration of Propofol Infusion and Awakening after Propofol-N2O-O2 Anesthesia.
Seung Jun LEE ; Ho Yeong KIL ; Sung Mi HWANG ; Dae Woo KIM
Korean Journal of Anesthesiology 1999;36(4):584-589
BACKGROUND: Several recent studies have suggested the context-sensitive half-time (CSHT) as a clinically more relevant measure of decreasing drug concentrations after a constant infusion of a given duration. The purpose of this study was to simulate the CSHT using a PK-SIM computer simulation program and compare this with duration of propofol infusion and real awakening time from anesthesia for the evaluation of CSHT as a useful tool of prediction of recovery from anesthesia. METHODS: Ninety-five ASA class I or II adult patients (18-55 yrs) scheduled for orthopedic elective surgery were randomly allocated into 5 groups according to duration of propofol infusion. Five groups were Group 1: less than 60 min, Group 2: 61-120 min, Group 3: 121-180 min, Group 4: 181-240 min, and Group 5: 241-300 min. Anesthesia was induced and maintained with propofol-nitrous oxide (67%)-oxygen (33%) according to Prys-Roberts' method. Propofol was discontinued immediately after skin closure and duration of infusion was checked. Duration of infusion, CSHT, and awakening time from anesthesia were compared and evaluated correlationship among them using a correlation coefficient. RESULTS: Plasma and effect site concentration after 5 hrs infusion of propofol derived from computer simulation was 3.3 microgram/ml. Awakening time for each group was 8.5-11.8 min and plasma CSHT for that was 6.4-9.5 min. The correlation coefficient (r) between duration of propofol infusion and awakening time was 0.98 (p<0.01) and that between CSHT and awakening time was 0.95 (p<0.01). CONCLUSIONS: There were strong relationship among duration of infusion of propofol, awakening time and CSHT. It seems that CSHT could be a good predictor of awakening from propofol-N20-02 general anesthesia.
Adult
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Anesthesia*
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Anesthesia, General
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Computer Simulation*
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Humans
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Orthopedics
;
Plasma
;
Propofol*
;
Skin