The serum concentration and urinary excretion of calcium, inorganic phosphorus and uric acid in 75 stone-former and 33 immobilized patients, comparing to those in 45 controls . The following results were obtained. 1. Serum calcium levels of stone-formers were significantly higher than those of controls in total, male and female. 2. Urinary calcium levels of stone-formers were significantly higher than those of controls in total and female, but not in male. 3. Serum and urinary levels of inorganic phosphorus did not show significant difference between stoneformers and controls. 4. Serum and urinary levels of uric acid in stone-formers were significantly higher than those of controls in total, male and female. 5. Serum and urinary levels of calcium in immobilized patients were higher than those of controls, but did not show significant difference between both groups. 6. Serum and urinary levels of inorganic phosphorus in immobilized patients were slight higher than those of controls, but did not show significant difference between both groups. 7. Serum and urinary uric acid levels of immobilized patients were lower than those of controls, but showed significant difference between both groups only in urinary uric acid levels. These results suggest the possibility that increased calcium and uric acid level may play some role in the genesis of urinary stone. Urinary uric acid level significantly decrease in immobilized state.
Calcium* ; Female ; Humans ; Male ; Phosphorus* ; Uric Acid* ; Urinary Calculi*

A clinical observation was made on the 58 nephrectomized patients during the period from Jan. 1978 to Dec. 1982 and the following were obtained. 1. The nephrectomies were performed in the 58 patients of the 465 urologic operations. (12.5%) 2. The most frequent age distribution ranged from 20 years old to 49 years old and the ratio of male to female was 1.3:1. 3. The causative disease of nephrectomy were tuberculosis (22.4%), renal stone (15.5%), renal injury (13.8%), hydronephrosis (12.1%), renal tumor (12.1%) and renal infection(10.3%) in order. 4. The common symptom were flank pain (41.4%), hematuria (37.9%), and frequency (17.2%). 5. The most frequently employed surgical approach of nephrectomy was though flank (79.3%). 6. The postoperative complications were 8 cases(13.8%),of which wound infection was the highest (6.9 %) 7. 47 cases (81.0%) were discharged within 15 days after operation.
Age Distribution ; Female ; Flank Pain ; Hematuria ; Humans ; Hydronephrosis ; Male ; Middle Aged ; Nephrectomy ; Postoperative Complications ; Tuberculosis ; Wound Infection ; Young Adult

To determine the effect of verapamil on experimental duodenal ulcer, pathologic assessment and secretory study were performed in the rats with ulcerogenic dose of cysteamine. The cysteamine increased gastric acid secretion and produced double duodenal ulcers at the proximal protion of the duodenum. Intramuscular injection of verapamil, 3 hours later, produced a significant decreased in gastric acid secretion which lasted at least 4 hours (cysteamine vs. cysteamine+ verapamil; 63.5 +/- 18.4 muEq vs. 25.5 +/- 9.0 muEq during the 1st hour after verapamil administration, 83.1 +/- 24.2 muEq vs. 27.8 +/- 12.3 muEq during the 2nd hour, 110.9 +/- 14.4 muEq vs. 38.5 +/- 25.9 muEq during the 3rd hour, 116.4 +/- 12.1 muEq vs. 40.7 +/- 29.6 muEq during the 4th hour, p less than 0.001). However, cysteamine-induced duodenal ulcers were not alleviated by two doses of intramuscular verapamil administration (4 mg/kg x 2). It is presumed that suppression of gastric acid secretion may not be sufficient to reduce cysteamine-induced duodenal ulcer formation or that verapamil itself may have aggresive effects against duodenum. To illucidate the exact role of verapamil in cysteamine-induced duodenal ulcer, further studies would be needed.
Animals ; *Cysteamine ; Duodenal Ulcer/chemically induced/*drug therapy/pathology ; Gastric Acid/*secretion ; Injections, Intramuscular ; Male ; Rats ; Rats, Inbred Strains ; Stomach/drug effects/*metabolism ; Verapamil/*therapeutic use

Gastrointestinal involvement has been reported to occur in about 5 to l0% of patients with lymphoma. The most common gastrointestinal site for a lymphoma is the stomach, followed by the small intestine and ileocecal region. When lymphoma is found in the esap us, generally it is with contiguous involvement of the gastric fundus, the cervical node, secondary to mediastinal lymph node compression, or a late manifestation of advanced desease. Such cases cannot be labeled as primary esophageal lymphoma. A search of the literature reveals that there have been about 20 or more published cases classified as esophageal lymphoma. However, more than ten cases are indistingishable from the case of distal esophageal involvement by gastric lymphoma. In 1935, Chiolero described a case of midesophageal stricture, which at autopsy was consistent with Hodgkin's disease for the first time. Berman reported an authentic case of primary histiocytic lymphoma confined to the lower esophagus. Only six or more cases were reported in literature until the present time. Here, a 30-year-old man with substernal discomfort was shown to have a mass lesion on the esophagus. The mass was proved to be malignant lymphoma on the histologic examination. This may be the first report dealing with spontaneous regression of maligant lymphoma of the esophagus possibly associated with the use of cimetidine.
Adult ; Autopsy ; Cimetidine ; Constriction, Pathologic ; Esophagus* ; Gastric Fundus ; Hodgkin Disease ; Humans ; Intestine, Small ; Lymph Nodes ; Lymphoma* ; Lymphoma, Large B-Cell, Diffuse ; Stomach

Herpetic esophagitis is a rare disease occuring mostly ie immunocompromised and cancer patient. It is also documented as self-limiting esopbagitis in young healthy adults. We report here a 30- year-old immunocompetent male patient with esophageal ulceration. Heryetic esophagitis was diagnosed by characteristic endoscopic and microscopic findings. And the diagnosis was confirmed by electron microscopic appearance. This immunocompetent patient recovered spontaneously with symptomatic treatment only. And repeat endoscopy and histology confirmed absence of herpes infection.
Adult ; Diagnosis ; Endoscopy ; Esophagitis* ; Humans ; Male ; Rare Diseases ; Ulcer

The ischemic coitis proximal to obstructive colon cancer was firstly reported by MacCallum and Kaisch in 1947. Nowsdays, its clinical importance and the study of pathogenesis is reported frequently. Because of the rare inciedence of this complicated condition this lesion could be overlooked which then could result anastomotic leakage, fecal fistula and peritonitis. Recently, we have examined a 61 year-old Korean male patient who had the complaints of acute abdominal pain and bloody diarrhea. The diagnosis of gangrenous ischemic colitis associated with obstucting rectal cancer was confirmed on the basis of sigmoidoscopic and operative and associated histopathological findings. After prompt surgical intervention, the patient was discharged with good improvement. The literatures are reviewed here with the case presentation.
Abdominal Pain ; Anastomotic Leak ; Colitis, Ischemic* ; Colonic Neoplasms ; Diagnosis ; Diarrhea ; Fistula ; Humans ; Male ; Middle Aged ; Peritonitis ; Rectal Neoplasms

Xanthogranulomatous pyelonephritis of the kidney usually occurs in association with urinary tract infection. obstruction and calculi. The diagnosis is made when a nephrectomy is performed for a nonfunctioning kidney or a mass indistinguishable from carcinoma. We experienced incidentally a case of xanthogranulomatous pyelonephritis. so the pathologic features and clinical presentation were discussed and the literature was reviewed.
Calculi ; Diagnosis ; Kidney ; Nephrectomy ; Pyelonephritis, Xanthogranulomatous* ; Urinary Tract Infections

Percutaneous transhepatic biliary drainge (PTBD) is a widely accepted technique for the decotnn of biliary obstruction. However, PTBD is most frequently performed in patients whose prognosis is poor becauase of unresectable malignancy, sepsis, or advanced age. And this technique has disadvantages which inclusdes loss of biliary fluids, fat malabsorption, discomfort and psychologic problem for many patients. A 68-year-old man admitted to the hospital because of obstructive jaundice. He had received cholectystectomy two yeas ageo due to the perforation of gallbladder caused by adenocarcinoma of cystic duct. An external PTBD was placed. But because of the chronic bile loss, a percutaneous endoscopic gastrostomy (PEG) was inserted and drainge of bile into the stomach through an extracoporeal circuit utilizing the PTBD as an exit and PEG as an entrance was achieved.
Adenocarcinoma ; Aged ; Bile ; Cystic Duct ; Drainage* ; Gallbladder ; Gastrostomy* ; Humans ; Jaundice, Obstructive ; Prognosis ; Sepsis ; Stomach

PURPOSE: This study was designed to review the clinical outcome of infants who underwent tracheostomy in the neonatal intensive care unit (NICU) of a single center in Korea during 16 years. METHODS: We retrospectively reviewed medical records of 33 patients who underwent tracheostomy in NICU of Samsung Medical Center between January, 1997 and December, 2013. We collected data on timing, indications, clinical outcomes, and complications of tracheostomy in the study patients. We also compared these variables with those in another single center study (study A) recently showing the outcome of infants who underwent tracheostomy in a NICU of USA during 10 years. RESULTS: The median gestational age and birth weight of the study patients were 35 weeks, and 3,200 g, respectively. Gestational age of the study patients was greater than that of study A (35 weeks vs. 27 weeks). The most common indication for tracheostomy was airway disease (69.7%) in our study. Bronchopulmonary dysplasia (9%) was less frequent indication for tracheostomy in our study when compared with in the study A (41%). Granuloma formation was the most common complication of tracheostomy (48%) and decannulation was accomplished in nine patients (27.3%). Although the mortality rate was 12.1%, no patient died from tracheostomy-related complications. CONCLUSION: Main causes of tracheostomy in our NICU are airway problems and neuromuscular diseases rather than bronchopulmonary dysplasia itself. For better clarification of clinical courses and outcomes related to tracheostomy performed in NICU in Korea, further study in a larger population will be needed.
Birth Weight ; Bronchopulmonary Dysplasia ; Gestational Age ; Granuloma ; Humans ; Infant* ; Infant, Newborn ; Intensive Care, Neonatal* ; Korea ; Medical Records ; Mortality ; Neuromuscular Diseases ; Retrospective Studies ; Tracheostomy*

PURPOSE: Heptaplatin (Sunpla) is a cisplatin derivative. A phase IIb trial using heptaplatin resulted in a 34% response rate with mild nephrotoxicity. We conducted a randomized phase III trial of heptaplatin plus 5-FU compared with cisplatin plus 5-FU in patients with advanced gastric cancer. MATERIALS AND METHODS: One hundred seventy-four patients (heptaplatin, n=88; cisplatin, n=86) from 13 centers were enrolled. The eligibility criteria were as follows: patients with pathologically-proven adenocarcinoma, chemonaive patients, or patients who had received only single adjuvant chemotherapy, and who had a measurable or evaluable lesion. On day 1, heptaplatin (400 mg/m2) or cisplatin (60 mg/m2) was given over 1 hour with 5-FU (1 gm/m2) on days 1~5 every 4 weeks. RESULTS: At the time of survival analysis, the median overall survival was 7.3 months in the 5-FU + heptaplatin (FH) arm and 7.9 months in the 5-FU + cisplatin (FP) arm (p=0.24). Of the FH patients, 34.2% (complete response [CR], 1.3%; partial response [PR], 32.9%) experienced a confirmed objective response compared with 35.9% (CR 0%, PR 35.9%) of FP patients (p=0.78). The median-time-to-progression was 2.5 months in the FH arm and 2.3 months in the FP arm. The incidence of neutropenia was higher with FP (28%) than with FH (16%; p=0.06); grade 3~4 nausea and vomiting were more frequent in the FP than in the FH arm (p=0.01 and p=0.05, respectively). The incidence of increased proteinuria and creatininemia was higher with FH than with FP; however, there was no statistical difference. There were no treatment-related deaths. CONCLUSION: Heptaplatin showed similar effects to cisplatin when combined with 5-FU in advanced gastric cancer patients with tolerable toxicities.
Adenocarcinoma ; Arm ; Chemotherapy, Adjuvant ; Cisplatin ; Drug Therapy, Combination ; Fluorouracil ; Humans ; Incidence ; Malonates ; Nausea ; Neutropenia ; Organoplatinum Compounds ; Proteinuria ; Stomach Neoplasms ; Vomiting