1.A Case of Syringoma Limited to the Vulva.
Dae Yeon KIM ; Dae Sik SEOK ; Jin Pyo HONG ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1986;24(1):142-144
Vulva syringomas are rare in reviewing literature. In our case, a 29-year-old had multiple papular lesions involving both sides of the vulva. Microscopically the lesion showed dilated cystic sweat ducts some of which have small comma like tails resembling tadpoles. It is the purpose of this report to present a rare case of syringoma which was limited to the vulva without involvement of other sites.
Adult
;
Humans
;
Larva
;
Sweat
;
Syringoma*
;
Vulva*
2.Cytogenetic Analysis of Chromosomal Abnormalities in Children.
Key Young SONG ; Kwang Man KIM ; Hong Dae CHA ; Joon Sik KIM ; Heung Sik KIM ; Chin Moo KANG
Journal of the Korean Pediatric Society 1990;33(2):153-161
No abstract available.
Child*
;
Chromosome Aberrations*
;
Cytogenetic Analysis*
;
Cytogenetics*
;
Humans
3.Serum erythropoietin and tumor necrosis factor ?in neoplasms, chronic inflammatory disorders, and iron deficiency anemias.
Jong Ho WON ; Dong Jip RA ; Dae Sik HONG ; Hee Sook PARK
Korean Journal of Medicine 1993;45(5):579-587
No abstract available.
Anemia, Iron-Deficiency*
;
Erythropoietin*
;
Iron*
;
Tumor Necrosis Factor-alpha*
4.A clinical and electrophysiological studies of vincristine neurotoxicity.
Joong Won KIM ; Jong Ho WON ; Dae Sik HONG ; Hee Sook PARK ; Yang Gyun LEE
Journal of the Korean Cancer Association 1991;23(2):252-258
No abstract available.
Vincristine*
5.Vitamin K Dependent Hemorrhagic Disease of the Newborn and Infancy with Intracranial Hemorrhage.
Ji Eun LEE ; Pal Dong KIM ; Hong Dae CHA ; Heung Sik KIM ; Chin Moo KANG
Journal of the Korean Pediatric Society 1990;33(9):1209-1215
No abstract available.
Humans
;
Infant, Newborn*
;
Intracranial Hemorrhages*
;
Vitamin K*
;
Vitamins*
6.Clinical and Statistical Obervation of Sick Babies in SCBU.
Kyung Tae KIM ; Dae Sik HONG ; Kew Taek KIM
Journal of the Korean Pediatric Society 1981;24(1):24-35
Clinical and statistical analysis were performed on 573 cases of neonates who were admitted in the special care baby unit, St. Benedict Hospital, from January 1978 to June 1979. The results were as following: 1) Sex ratio of male to female was 1.04:1. 2) According to the route of admission, The ratio of "non-referred patients" to "referred patients was 1.86:1. 3) About the parity incidence, the first baby was 57.1%, the second was 29.7%, and the third was 9.6%. 4) About the age on admission, the babies of the one day I\of age was 45.5% and 86.9% was within 1 week of age. 5) According to the duration of admission, 1-7 days group was the most common(59.6%) and the next were 8-14 days group(24.6%), 15-21 days group(6.1%) 6) According to the duration of admission, 1-7 days group was the most common(59.6%) and the next were 8-14 days group(24.6%), 15-21 days group(6.1%). 7) About the maternal education of non-referred patients, group of high school educated was the most common(45.6%), followed by college(22.3%), middle school(15.3%), and primary school(9.7%). 8) On distribution of the maternal age of non-referred patients, the group of 20-30 years of age was the most common(51.7%), followed by 20-25 years of age (23.3%). Admission rate according to maternal age, higher incidence was seen over 31 years of age. 9) The most common placentas weight of non-refered patients was 600-800 gm. Group(39.9%) and the highest incidence of pre-term was the group of 200-400gm. 10) The most frequent problem was hyperbilirubinemia, followed by prematurity, infectious diseases, respiratory tract diseases, congenital anomalies, diseases associated with metabolism and birth injury. 11) According to the age of initiation of treatment in hyperbilirubinemic patients, the most common age was 4 day(30.5%) and the next was 3 days(25.1%), Suspected causes ware idiopathic(51.2%), blood group incompatibility(17.1%), prematurity(15.3%) and so on. 12) The main diseases associated with prematurity were hyperbilirub-inemia(47.9%), pneumonia(15.1%), RDS(8.4%). 13) Mortality rate were 26.6% in pre-term, 7.4% in post-term, 2.6% in full-term and mortality rate of all admission was 8.0%. Generally, the shorter gestational age and lower birth weight, the higher the mortality rate of premature infants was observed. 14) The leading causes of death were immaturity(48.5%), RDS(24.2%), pneumonia(21.2%) in pre-term, pneumonia(27.3%), kernicterus(18.2%) in full-term and anencephaly & placental dysfunction syndrome in postern 2 cases.
Anencephaly
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Birth Injuries
;
Birth Weight
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Cause of Death
;
Communicable Diseases
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Education
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Female
;
Gestational Age
;
Humans
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Hyperbilirubinemia
;
Incidence
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Infant, Newborn
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Infant, Premature
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Male
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Maternal Age
;
Metabolism
;
Mortality
;
Parity
;
Placenta
;
Respiratory Tract Diseases
;
Sex Ratio
7.Evaluation of Hematopoietic Abnormalities and Apoptosis in Myelodysplastic Syndromes Using Long Term Bone Marrow Culture System and In Situ Nick End Labeling Method.
Jong Ho WON ; Dae Sik HONG ; Hee Sook PARK ; Jung Shin LEE
Korean Journal of Medicine 1997;53(4):469-481
OBJECTIVES: The myelodysplastic syndromes (MDS) are a group of acquired clonal hematopoietic disorders characterized by peripheral cytopenias and a hypercellular or normocellular dysplastic bone marrow. The mechanisms responsible for development of MDS are not known. We performed this study to evaluate the hematopoietic abnormalities and apoptosis in MDS. METHODS: Long-term bone marrow culture (LTBMC) was performed for colony assays, cobblestone area assay, stromal morphologic changes from 7 patients with MDS and 7 normal controls. In situ nick end labeling (ISNEL) method was performed for detection of apoptosis from LTBMC in 7 patients with MDS and 7 normal controls. ISNEL method also performed in bone marrow cell bloc samples in 36 patients with MI3S. RESULTS: Viability of nonadherent cells from LTBMC of patients with MDS was not decreased compared with normal controls at 1 week, but significantly decreased at 2 and 3 weeks compared with normal controls (P<0.0001). Formation of the cobblestone areas from patients with MDS was slightly decreased compared with normal controls at 1st week, but significantly decreased at 2nd and 3rd weeks compared with normal controls (P<0.0001). Slightly decreased compared with normal controls at 1 week, but significantly decreased at 2 and 3 weeks compared with normal controls (P<0.0001). Stromal layers produced in LTBMC of normal controls and 1 patient with MDS were detected at 1 week and were formed confluent stroma from 3 weeks, but another patients with MDS who did not form a confluent stroma. Patients with MDS had significantly lower colony forming unit granulocyte-macrophage (CFU-GM) compared with normal controls at 1 (P<0.01) and 2 weeks (P<0.001) of LTBMC. Two weeks of LTBMC resulted more profound inhibition of CFU-GM formation than 1 week (P<0.0001). Apoptotic cell death was absent in adherent and non adherent cells from normal controls at 1 and 2 weeks, but massive apoptotic cell death was found in adherent and non adherent cells from patients with MDS at 1 and 2 weeks and the degree of apoptosis was profound at 2 weeks compared with 1 week. Among the 36 patients, fifteen patients demonstrated varying degrees of apoptosis positive cells, 4 having low, 8 intermediates, and 3 high scores. Remaining 21 patients showed absent apoptosis or only occasional positive cells. CONCLUSION: Hematopoietic abnormalities such as a failure of differentiation are caused by the stromal defects and the biologic basis of the apparent paradox of peripheral cytopenias in the face of hypercellular (or normocellular) marrow is related by intramedullary apoptotic cell death of the stromal and hematopoietic cells.
Apoptosis*
;
Bone Marrow Cells
;
Bone Marrow*
;
Cell Death
;
Granulocyte-Macrophage Progenitor Cells
;
Humans
;
In Situ Nick-End Labeling*
;
Myelodysplastic Syndromes*
;
Stem Cells
8.Histopathological Changes in Psoriasis Under Occulsive Dressing with Topical Corticosteroids.
Dae Sung CHOI ; Jung Kwoun SUH ; Soo Gil SUHL ; Hong Sik KIM
Korean Journal of Dermatology 1970;8(2):41-46
Histopathological changes under occulsive dressing with 0.1% triamcinolone acetonide cream, 0 025% fluocinolone acetonide cream, and 1% hydrocortisone cream were compared each other and with the changes following topical application of 5% ammoniated mercury ointment without occulsion in five cases of psoriasis vulgaris. 1) The earliest changes noticed were the diminution of the papillary edema, the appearence of the granular layer and the disappearence of parakeratosis. 2) A week after treatment, the remarkable changes revealed were the thinning of the epidermis, the diminution of acanthosis, papil]ary edema and cell infiltration of the upper dermis and the appearence of the granular layer. 3)The capillary dilatation remained unchanged even two weeks after treatment in all groups. 4) Among these drugs, the best respanse revealed was triamcinolone cream, the next was fluocinolone cream. The response of hydrocortisone cream was poorer than fluocinolone cream and ammoniated mercury ointment was even more poorer than hydrocortisone cream.
Adrenal Cortex Hormones*
;
Bandages*
;
Capillaries
;
Dermis
;
Dilatation
;
Edema
;
Epidermis
;
Fluocinolone Acetonide
;
Hydrocortisone
;
Parakeratosis
;
Psoriasis*
;
Triamcinolone
;
Triamcinolone Acetonide
9.Thrombopoietin.
Korean Journal of Medicine 1999;57(4):449-452
No abstract available.
Thrombopoietin*
10.A case of infection-associated hemophagocytic syndrome(IAHS).
Hong Ok RYOO ; Kyoo Hwan KIM ; Dae Sik KOO ; Jong Hwi JUN
Korean Journal of Infectious Diseases 1993;25(1):71-77
No abstract available.