No abstract available.
Typhoid Fever*

The author studied the infection rates of Clonorchiis sinensis in the inhabitants of Kyungpook Province, and surveyed infestation rates of Clonorchis metacercarias in the twelve kinds of fresh water fishes for the purpose of the eradication. plan of clonorchiasis of Kyungpook Province. The examination was continued from April 1960 to October 1962 with 24,252 inhabitants ranging from four months to over sixty aged. All the family were tested intradermally with Clonorchis antigen and then confirmed the eggs by M.G.L. technique. The results of the examination were summarized as follows. I. The infection rate of the inhabitants; In the people tested, 27.7 percent was infected with Clonorchis sinensis. There were no remarkable differences in the infection rates among each Districts; River side inhabitants(Yungchun-Gun 23.6 percent, Andong-Gun 27.4 percent), paddy field inhabitants(Yungchun- Gun 23.6 percent, Sangchu-Gun 29.1 percent) and mountain side inhabitants (Chungsong-Gun 23.8 percent, Yungyang-Gun 27.7%). However, the infection rates of the river side peoples were slightly higher than that of the districts far from the river. The infection rate of the male was 34.98 percent (4 ,628 out of 12,230), while the female was 18.96 percent (2090 out of 11022). The maximum infection rate of the male group was observed in the 35-39 age group (73.8 %) and in female, 55-59 age group (34.l percent) respectively, however it was gradually decreased in the senile group. II. The infection rates of the family group; Those infected in both husband and wife were 28 percent(357 out of 1,289), husband only was 52 percent (672 out of 1,289) and wife only was 4 percent (50 out of 1,289). The children of the infected parents revealed higher morbidity than that of the non-infected parents. The children of the infected father revealed much morbidity than that of the mother's side. On the contrary, children's morbidity rate of the infected widow was higher than that of the widower. III. The infestation rates of fresh water fishes; The metacercaria of Clonorchis sinensis was found in the flesh exclusive of the Misgurnus anguillicaudatus and Zacco platypus in the 11 kinds of fresh water fishes. The maximum infestation rate of 55.8 percent was revealed at Pseudorasbora parva and next to it was Sarcocheilichthys wakiyae of 5l.7 percent. The number of metacercaria in flesh was decreased as compared to the previously examined level.
parasitology-helminth-trematoda-Clonorchis sinensis ; epidemiology ; Misgurnus anguillicaudatus ; Zacco platypus ; Sarcocheilichthys wakiyae ; Pseudorasbora parva

Metacercariae of Centrocestus species were found from a brackish water fish, Tribolodon taczanowskii Steindachner in the downstream of Hyungsan river. Thirty one fishes out of 154 examined (31.8 percent ) were infected with the metacercariae of Centrocestus. sp. Metacercariae were fed to the mouse experimentally and adult worms were recovered from the intestinal mucosa. And they were identified C. asadai Mishima and compared with the prereported Centrocestus sp.
parasitology-helminth-trematoda-Centrocestus asadai ; Tribolodon taczanowskii ; metacercariae

No abstract available.
Abruptio Placentae* ; Female ; Pregnancy

No abstract available.
Abruptio Placentae* ; Female ; Pregnancy

An example of lymphoblastic lymphosarcoma was found in a 7-year-old male brown bear (Ursus arctos) that died after having a 7-month history of depression, anorexia and watery diarrhea. Grossly the mesenteric lymph nodes were enlarged to approximately 4 to 6 times their normal size and histologically diagnosed as lymphoblastic lymphosarcoma. The small intestinal mucosa was corrugated and had severe mural thickening due to infiltrated neoplastic cells. Hepatic metastasis was also noted. This is the first reported case of lymphosarcoma in Ursidae in Korea. As an incidental finding, endogenous lipid pneumonia was noted in the lung.
Animals ; Animals, Zoo ; Fatal Outcome ; Intestinal Mucosa/pathology ; Intestine, Small/pathology ; Korea ; Liver/pathology ; Liver Neoplasms/secondary/veterinary ; Lung/pathology ; Lymph Nodes/*pathology ; Male ; Mesentery ; Pneumonia, Lipid/pathology/veterinary ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/pathology/*veterinary ; *Ursidae

The authors reviewed 16 cases of spontaneous spinal epidural hematoma(SSEH) described in the Journal of the Korean Neurosurgical Society and one case unpublished case of our own. Attention was focused on sex,age, medical history, position and vertebral level of the hematoma, preoperative neurological condition and operative result. This study comprised 17 patients, 14 males and 3 females, between five and 79 years old. All vertebral segments were affected, though the thoracic area predominated. In 13 patients, sensory and/or motor deficit was incomplete and in four, SSEH resulted in complete preoperative sensory and motor loss. In all patients, the hematomas were removed surgically through total laminectomy. In four, postoperative recovery was total, but in ten, was incomplete, and the neurological condition of three showed no improvement. We concluded that in cases of SSEH, this operation is the treatment of choice.
Aged ; Female ; Hematoma ; Hematoma, Epidural, Spinal* ; Humans ; Laminectomy ; Male

The authors report a case of postoperative supratentorial epidural hematoma as a complication of acoustic neurinoma surgery. The 43-year-old man presented with hearing difficulty on the left side and decreased facial sensation. MR imaging demonstrated a huge, cystic left acoustic neurinoma and the retromastoid suboccipital approach was used for gross-total resection of the tumor. Postoperatively, the patient was drowsy and showed right hemiparesis. Computed tomographic scanning revealed a huge epidural hematoma in the left parietooccipital convexity. The intraoperative course was uneventful. Immediate craniotomy was performed and the epidural hematoma was removed. Bleeding from the superior sagittal sinus occurred, but was completely controlled. Postoperatively, the patient was neurologically normal, except for mild left facial weakness. Remote postoperative intracranial hemorrhage is a rare complication of craniotomy with significant morbidity and mortality. Such hemo-rrhages are likely to develop at or soon after surgery and can be related to the craniotomy site, operative positioning, and nonspecific mechanical factors. In this case, mechanical displacement of the brain secondary to excessive dehydration and CSF drainage was thought to be the cause of postoperative epidural hematoma. Clinical awareness of this rare but potential complication is essential to its early diagnosis and treatment. Difficulty in awakening from anesthesia and the development of new neurological deficits not attributable to the operative site are the most important keys to early diagnosis. Computed tomography is the diagnostic method of choice.
Acoustics* ; Adult ; Anesthesia ; Brain ; Craniotomy ; Dehydration ; Drainage ; Early Diagnosis ; Hearing ; Hematoma* ; Hemorrhage ; Humans ; Intracranial Hemorrhages ; Magnetic Resonance Imaging ; Mortality ; Neuroma, Acoustic* ; Paresis ; Sensation ; Superior Sagittal Sinus

Application of membranes for guided tissue regeneration(GTR) have been confined to the subgingival barrier functions; however, many studies have provided evidence that some drugs, including tetracycline, initially can promote the growth of periodontal ligament or alveolar bone in peridontal therapy. Osseous regeneration in periodontal defects is increased by local administration of tetracycline due to its anti-collagenolytic effect, which enhances bone-forming ability via osteoblast cell chemotaxis and reduced bone resorption. The aim of this study was to evaluate effects of tetracycline loaded poly-L-lactide(PLLA) barrier membranes for guided bone regenerative potential. Tetracycline was incorporated into the PLLA membrane with the ratio 10% to PLLA by weight. Ability to guided bone regeneration of the membranes were tested by measuring new bone in the tibial defects(7x10x5 mm3) of the beagle dog for 4, 5, and 6 weeks. In control, drug-unloaded PLLA membranes were used in same size of defect. In histologic finding of the defect area, a few inflammatory cells were observed in both groups. These membrane were not perforated by connective tissue and maintained their mechanical integrity for the barrier function for 4-6 weeks. New bone formation was greater in defects covered by tetracycline-loaded membrane than in defects covered by drug- unloaded membranes. In bone regeneration guiding potential test, tetracycline-loaded membrane was more effective than drug- unloaded membranes(p<0.05). These results suggest that tetracycline-loaded PLLA membranes potentially enhance guided bone regenerative efficacy and might be a useful barrier for GTR in periodontal treatment.
Animals ; Bone Regeneration* ; Bone Resorption ; Chemotaxis ; Connective Tissue ; Dogs* ; Membranes* ; Osteoblasts ; Osteogenesis ; Periodontal Ligament ; Regeneration ; Tetracycline

Cyclosporin A is a cyclic polypeptide produced by the metabolism of fungi. It is widely used at present as immunosuppressive treatment following organ transplants. It is also used to deal with autoimmune diseases such as rheumatoid arthritis or type II diabetes. Gingival hyperplasia is one of the most frequent side-effects associated with the prescription of Cyclosporin A. The mechanisms involved in Cyclosporin A induced gingival hyperplasia are not yet clear. In vitro Cyclosporin A promotes proliferation of gingival fibroblasts, that Cyclosporin A act as a mitogen. Its action is based on mitosis of gingival fibroblasts regulated by cell cycle regulatory proteins. It was the purpose of the present study to examine the effects of Cyclosporin A on human gingival fibroblasts by means of biological and biochemical criteria. In this present study, we examined change of cell proliferation, cell activity, cell viability and cell cycle progression after application of Cyclosporin A. We also examined expression of cell cycle regulatory proteins by western blot analysis. Human gingival fibroblasts were cultured for 48 hours with application of Cyclosporin A at concentrations of 0.01, 0.1, 1, and 10 ng/ml. Cyclosporin A(1 ng/ml) significantly increased the cell activity of gingival fibroblast. Proliferation and viability of gingival fibroblasts were also increased in group treated with 1 ng/ml of Cyclosporin A compared to control group. In the cell cycle analysis, S phase was increased and G1 phase was decreased in the group treated with 1 ng/ml of Cyclosporin A. Cyclosporin A increased the expression of cdk4 and inhibited the expression of pRB and p21. These results suggest that 1 ng/ml of Cyclosporin A may increase the cell cycle progression of human gingival fibroblasts, and its mechanisms may increase the expression of cdk4 and decrease the expression of pRB and p21.
Arthritis, Rheumatoid ; Autoimmune Diseases ; Blotting, Western ; Cell Cycle Proteins ; Cell Cycle* ; Cell Proliferation ; Cell Survival ; Cyclosporine* ; Fibroblasts* ; Fungi ; G1 Phase ; Gingival Hyperplasia ; Humans* ; Metabolism ; Mitosis ; Prescriptions ; S Phase ; Transplants