No abstract available.
Colon* ; Diverticulitis*

A clinical observation was made on patients with the tumors of the genitourinary tract, who were admitted to the Department of Urology, Kyungpook National University Hospital during 10 years period from January 1970 to December 1979. Out of 1606 total hospital admissions. 284 were due to the tumors of the genitourinary tract, giving rate of 17.68%, sex ratio, male to female, was 6.89:1 The most frequently involved age group was the 7th decade, being 31% of total, followed by the 6th decade (22%). About 85.21% was seen at age of 40 and over. Prostate was the most commonly involved organ comprising 122 (42.96%) out of 284 cases of the tumors of the genitourinary tract, followed in frequency by bladder in 77 (27.11%), kidney in 40 (14.08%), and penis in 24 (8.45%). The tumors were benign in 123 and malignant in 161, giving ratio of benign to malignant approximately 1:1.3. The most common type among benign group was B.P.H. and among malignant type, bladder carcinoma. Pathologic diagnosis was performed on 174 cases. Out of these, 52 were diagnosed as transitional cell carcinoma of bladder, followed in frequency by B.P.H. in 36 and squamous cell carcinoma of penis in 16.
Carcinoma, Squamous Cell ; Carcinoma, Transitional Cell ; Diagnosis ; Female ; Gyeongsangbuk-do ; Humans ; Kidney ; Male ; Penis ; Prostate ; Sex Ratio ; Urinary Bladder ; Urology

Early detection of renal pelvic tumor is essential since the survival rate is markedly reduced if the lesion has invaded beyond the pelvic wall. Accurate preoperative diagnosis is of considerable practical importance. since the surgeon should choose an unique operative approach conducive to a nepbroureterectomy with removal of a cuff of bladder. Selective renal angiography plays an important role in the diagnosis of renal tumor, but little is known about the importance of selective renal angiography in renal pelvic tumor. We performed selective renal angiography in 9 patients with clinically diagnosed renal pelvic tumor in this department during 2 years and 4 months period from March 1979 to June 1981. 7 out of 9 patients were diagnosed with transitional cell carcinoma of the renal pelvis histologically and remaining 2, leiomyoma of the renal parenchyma and renal cell carcinoma. The angiographic findings in 7 patients with transitional cell carcinoma showed hypertrophy of the pelviureteral artery and a diminished branching of vessels in 5, respectively, and defects in the nephrographic phase, neovascularity and vascular displacement in 2 each.
Angiography ; Arteries ; Carcinoma, Renal Cell ; Carcinoma, Transitional Cell ; Diagnosis ; Humans ; Hypertrophy ; Kidney Pelvis ; Leiomyoma ; Survival Rate ; Urinary Bladder

OBJECTIVE: CD40 and the TNFR belong to the NGF/TNFR supergene family. Ligation of CD40 on B cells induces activation ignals leading to proliferation, Ig isotype class switching, germinal center formation but also induces Fas antigen expression.In addition,CD40 ligation induces pro-inflammatory cytokines including TNF-alpha and LT-alpha gene transcription by human B cell.TNF-alpha is a pleiotropic cytokine and also induces Fas antigen expression on various cells. Lately it has been known that TNF-alpha plays an important role in the pathogenesis of chronic inflammatory diseases,including rheumatoid arthritis,or chronic inflammatory bowel diseases.However there have been occurrence of autoantibodies,or autoimmune disease such as lupus after use of anti TNF-alpha blocking agents. In this report,we tested the relationship and biological significance of CD40 ligation and TNFR signaling with respect to Fas antigen expression on human B cells. METHODS: Ramos Burkitt's lymphoma B cell was used as a prototype of ger-minal center B lymphocyte,and R2G6 cell was utilized as a model of activated germinal center B cell.CD40 lgation was performed by the coculture with CD40 ligand bearing L-293 cells,or anti-CD40 monoclonal antibody,whereas control was obtained with CD-8-L-293 cells or control antibody.Expression of Fas antigen was determined with flow cytometer.Apoptosis assay was conducted by two ways.Alamar blue reduction assay after sIgM cross linking or anti-Fas anti-body,in the presence or absence of CD40 ligation or TNF-alpha .In addition,DNA content assay was utilized to make sure the proportion of apoptotic Ramos B cells by various treatments. RESULTS: 1)CD40 and TNF-alpha induced Fas antigen expression on Ramos B cell line cells and rendered them susceptible to Fas-mediated apoptosis.2)CD40 and TNFR signaling upregulate Fas antigen independently.3)Both TNFR and CD40 signaling rescue sIgM crosslink induced apoptosis of Ramos B cell line cells,only CD40,but not TNFR,signaling rescues Ramos cells from Fas-mediated apoptosis. CONCLUSION: Taken together,these results demonstrate that B cell signaling via two distinct members of the NGF/TNFR superfamily,CD40 and TNFR, independently engage the Fas pathway and provide mechanisms for eliminating B cells.Acting alone,both signals will ready B cells for Fas-mediated apoptosis. In concert with sIg signaling,the rescue effect provided uniquely by CD40 ligation assures the selective survival of only those B cells which have bound antigen and presented it to antigen-specific T(h) cells .
Antigens, CD95* ; Apoptosis ; Autoimmune Diseases ; B-Lymphocytes ; Burkitt Lymphoma ; CD40 Ligand ; Cell Line ; Coculture Techniques ; Cytokines ; Germinal Center ; Humans* ; Immunoglobulin Class Switching ; Ligation ; Receptors, Tumor Necrosis Factor* ; Tumor Necrosis Factor-alpha*

Use of colorectal stents has increased dramatically over the last decades. Colorectal stents offer an alternative way to relieve fatal intestinal obstruction and can take place of emergency surgery, which associated with significant morbidity and mortality and a high incidence of stoma creation, to elective resection. Although there remain a few concerns regarding the use of stents as a bridge to surgical resection, use of self-expandable metallic stents for palliation in patients with unresectable disease has come to be generally accepted. Advantages of colorectal stents include acute restoration of luminal patency and allowance of time for proper staging and surgical optimization, and the well-known disadvantages are procedure-related complications including perforation, migration, and stent failure. General indications, procedures, and clinical outcomes as well as recent evidences regarding the use of colorectal stents will be discussed in this review.
Colorectal Neoplasms ; Emergencies ; Humans ; Incidence ; Intestinal Obstruction ; Mortality ; Phenobarbital ; Stents*

A rare case of benign hemorrhagic renal cyst ruptured into the pyelocaliceal system, which occurred in a 44-year-old male, is presented. The literature is reviewed briefly.
Adult ; Hemorrhage ; Humans ; Male

Transcatheter arterial embolization (TAE) is widely used in the treatment of unresectable hepatocellular carcinoma. Its common complications are right upper quadrant pain, nausea, vomiting, and rare complications include focal pancreatic necrosis, gastric ulcer, renal failure, DIC, biliary tree necrosis and splenic infarction and so on. It has been reported that hepatobronchial fistula could develop as a pleuropulmonary complication of liver abscess. We report a case of hepatobronchial fistula caused by complicating liver abscess in a patient with hepatocellular carcinoma who was treated with TAE.
Biliary Tract ; Carcinoma, Hepatocellular* ; Dacarbazine ; Fistula* ; Humans ; Liver Abscess ; Nausea ; Necrosis ; Renal Insufficiency ; Splenic Infarction ; Stomach Ulcer ; Vomiting

Right-sided varicocele is a relatively rare disease, which could be caused by retroperitoneal pathology, situs Inversus or ananomalous termination of the right internal spermatic vein into the right renal vein or the left renal vein. Herein we report a rare case of right-sided varicocele in a 31-year-old fertile man with situs inversus.
Adult ; Humans ; Pathology ; Rare Diseases ; Renal Veins ; Situs Inversus* ; Varicocele* ; Veins

No abstract available.
Drug Therapy, Combination* ; Multiple Myeloma*

Human cytomegalovirus (HCMV) glycoprotein H (gH) is one of target molecules in the human immune response to HCMV infection. This study was performed to rneasure the immune responses to HCMV gH in human sera by the expression of HCMV gH in eukaryotic cells. Amplified DNA from the gene encoding gH of HCMV by polymerase chain reaction was cloned into pcDNA3 to construct eukaryotic expression vector. Immunofluorescent staining revealed that the expressed gH in mammalian cells was reactive with the specific monoclonal antibody. Antibody titer in patient's sera with HCMV infection was measured with HCMV-infected fibroblasts and HCMV gH expressed in mammalian cells. Anti-HCMV gH antibody titer was higher in patient group than in healthy control group. There was no correlation between the antibody titer to the whole HCMV and neutralizing antibody titer, and between the antibody titer to whole HCMV and whole gH. Conclusively it is highly recommendable to use the defined antigen such as HCMV gH for the detection of antibody in HCMV-infected persons in the aspect of immunological properties.
Antibodies, Neutralizing ; Clone Cells ; Cytomegalovirus* ; DNA ; Eukaryotic Cells ; Fibroblasts ; Glycoproteins* ; Humans* ; Polymerase Chain Reaction