1.A Case of Syringoma Limited to the Vulva.
Dae Yeon KIM ; Dae Sik SEOK ; Jin Pyo HONG ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1986;24(1):142-144
Vulva syringomas are rare in reviewing literature. In our case, a 29-year-old had multiple papular lesions involving both sides of the vulva. Microscopically the lesion showed dilated cystic sweat ducts some of which have small comma like tails resembling tadpoles. It is the purpose of this report to present a rare case of syringoma which was limited to the vulva without involvement of other sites.
Adult
;
Humans
;
Larva
;
Sweat
;
Syringoma*
;
Vulva*
2.Common Sites, Etiology, and Solutions of Persistent Septal Deviation in Revision Septoplasty.
Hong Ryul JIN ; Dae Woo KIM ; Hahn Jin JUNG
Clinical and Experimental Otorhinolaryngology 2018;11(4):288-292
OBJECTIVES: To investigate the common causes of persistent septal deviation in revision septoplasty and to report the surgical techniques and results to correct them. METHODS: A total of 100 consecutive patients (86 males) who had revision septoplasty due to persistent septal deviation from 2008 and 2014 were included in the study. Their mean age was 35.6 years and the mean follow-up duration was 9.1 months. Presenting symptoms, sites of persistent septal deviation, techniques used to correct the deviation, and surgical results were reviewed. RESULTS: The mean interval between primary and revision surgery was 6.2 years. Forty-eight patients received revision septoplasty and 52 received revision septoplasty combined with rhinoplasty. Nasal obstruction was the most presenting symptom in almost all patients. The most common site of persistent septal deviation was middle septum (58%) followed by caudal septum (31%). Correcting techniques included further chondrotomy and excision of deviated portion in 76% and caudal batten graft in 39%. Rhinoscopic and endoscopic exams showed straight septum in 97% and 92 patients had subjective symptom improvement postoperatively. CONCLUSION: Middle septum and caudal septum were common sites of persistent deviation. Proper chondrotomy with excision of deviated middle septum and correction of the caudal deviation with batten graft are key maneuvers to treat persistent deviation.
Follow-Up Studies
;
Humans
;
Nasal Obstruction
;
Rhinoplasty
;
Transplants
3.Changes in Eye Movement Amplitude after Conjunctivo-Limbal Autograft in Patients with Recurrent Pterygium, Ocular Motility Restriction
Hye Jin HONG ; Min Gu HUH ; Dae Jin PARK
Journal of the Korean Ophthalmological Society 2021;62(1):36-45
Purpose:
To investigate changes in eye movement amplitude after conjunctival recession and conjunctivo-limbal autograft for treating recurrent pterygium with ocular motility restriction.
Methods:
We retrospectively analyzed 18 eyes of 16 patients who had recurrent pterygium with ocular motility restriction, who had received conjuntivo-limbal autografts from January 2011 to December 2019 and who had been followed-up for more than 6 months. We evaluated changes in eye movement amplitude, best corrected visual acuity, uncorrected visual acuity, corneal astigmatism and keratometry, and recurrence and complication rates before and after surgery.
Results:
The mean age of the patients was 63.9 ± 9.7 years. Eye movement amplitude increased significantly from 5.80 ± 1.70 mm preoperatively to 7.02 ± 1.37 mm postoperatively (p < 0.001). The mean UCVA increased from 0.67 ± 0.46 preoperatively to 0.36 ± 0.35 postoperatively (p < 0.001). The mean corneal astigmatism decreased from 3.51 diopters (D) preoperatively to 1.22 D postoperatively (p = 0.001). According to the power vector analysis, M and B were significantly reduced after the surgery, but the changes in J0 and J45 were not significant. No recurrence of pterygium was observed.
Conclusions
Eye movement amplitude for severe recurrent pterygium with symblepharon or ocular motility restriction quantitatively measured the range of ocular movement clinically and was applied to determine the severity of recurrent pterygium and predict the surgical outcome. Conjunctivo-limbal autograft for severe recurrent pterygium is thought to be a safe and effective surgical method because it solves the ocular motility restriction caused by adhesions and has low recurrence rates, although it requires the skilled experience and techniques of the operator and a long operation time.
5.A Case of Childhood Systemic Lupus Erythematosus Showing Erythema Multiforme-like Eruption.
Dae Yeon KIM ; Jin Pyo HONG ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1987;25(2):245-249
We present a case of childhood systemic lupus erythematosus(SLE) with renal disease in a 10-year-old girl with multiple, scattered, erythema multiforme-like eruptions on the face, trunk, forearms and lower legs. Serologic abnormalities included hypocomplementemia, high ANA & anti DNA titers, and LE cell test was positive. The histologic finding of the lesion showed leukocytoclastic vasculitis and direct immunofluorescent test revealed linear deposit of IgM at the dermoepiderrnal junction. Electron microscopy showed glomerular subepithelial depasition of eletron dense material in the kidney.
Child
;
DNA
;
Erythema*
;
Female
;
Forearm
;
Humans
;
Immunoglobulin M
;
Kidney
;
Leg
;
Lupus Erythematosus, Systemic*
;
Microscopy, Electron
;
Neutrophils
;
Vasculitis
6.Mixed Gangliocytoma-Pituitary Adenoma: A case report.
Dong Sug KIM ; Dae Hong SUH ; Mi Jin KIM ; O Lyong KIM
Korean Journal of Pathology 1998;32(2):138-141
The mixed gangliocytoma-pituitary adenoma is a very rare intracranial neoplasm, and it is frequently associated with endocrine symptoms; acromegaly, Cushing's disease, galactorrhea and amenorrhea. Morphologically it shows a mixture of gangliocytoma and pituitary adenoma in various proportions. In the area of gangliocytoma, there is no neoplastic glial component. The portion of pituitary adenoma consists mainly of chromophobe cells. There are three hypotheses in its histogenesis. We report a case of a 41 year-old lady presented with acromegaly and amenorrhea existing for 3 years. On magnetic resonance image, there is a dumbell-shaped mass in the sellar region. Histologically it showed typical features of mixed gangliocytoma-pituitary adenoma. This case is presented in the view of its rarity and interesting possible histogeneses.
Acromegaly
;
Adenoma*
;
Adult
;
Amenorrhea
;
Brain
;
Brain Neoplasms
;
Female
;
Galactorrhea
;
Ganglioneuroma
;
Humans
;
Pituitary Neoplasms
;
Pregnancy
7.A Case of Malignant Melanoma Associated with Squamous Cell Carcinoma.
Jin Pyo HONG ; Young Dae KIM ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1987;25(6):827-831
We report a interesting case of malignant melanoma associated with squamous cell carcinoma, A 75-year-old woman has been suffered from a 4*3*3cm sized slowly growing protruding mass for 2 years based on the previous existing black or dark brownish colored round plaque on the left buttock since 10 years. A hard fixed lymph node is palpable on the left inguinal area. Biopsy specimens from the plaque and mass revealed typical findings of the superficial spreading malignant rnelanoma and squamous cell carcinoma. Simple mass excision and lymph node dissection were performed.
Aged
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Biopsy
;
Buttocks
;
Carcinoma, Squamous Cell*
;
Female
;
Humans
;
Lymph Node Excision
;
Lymph Nodes
;
Melanoma*
8.Effects of calcipotriol(MC 903), a novel synthetic derivative of vitamin D3 on the growth of cultured human keratinocytes and melanocytes.
Dae Kwang HONG ; Tae Jin YOON ; Nack In KIM ; Jai Kyung PARK ; Choong Rim HAW
Korean Journal of Dermatology 1992;30(6):811-823
The cutaneous synthesis of vitamin D in response to ultraviolet radiation exposure is the most important factor in maintaining vitamin D balance in Man. The skin is not only the site of vitamin D synthesis, but also a target organ for calcitriol(1, 25-dihydroxy-vitamin D) which is naturally occuriag, hormonally active form of vitamin E. It is now known that calcitriol inhibits the proliferation of epidermal cells and induces her differentiation. In this study, epidermal keratinocytes and melanocytes were isilated from the neonatal foreskin, and were culturod using a MCDB 153 and modified TIC media, respectively. And then various concentratioris of calcipotriol(MC 903), a synthetic aralogue of calcitriol, were added to each culture. The effects of calcipotriol on the growth of human keratinocytes and melanocytes were investigated. The results were as follows : 1. The addition of calopotriol to human keratinocyte and melalocyte cultures inhibited their proliferation in a dosdependent manner. 2. Calcipotriol had no effects on the melanization process of the melanocyte. 3. Calcipotriol was found to inhibit the proliferation, however it induced the terminal differentiation of cultured keratinocytes, as judged by morphologicai changes. The decreased density of kerationcytes, The formation of cornified cells, and the cellular destruction in a concentration of 10 M of calcipotriol were observed. 4. By using the light atid the electron microscope, we observed that the epidermal thickness was decreased and terminal differentiation was facilitateir. Living Skin Equivalent (LSE) according to the increasing concentration of calcipotriol. A]i)parent cytotoxic effects were observed in 10 M, 10 M of calcipotriol. In summary, the above results indicate that the addition of calcipotriol to the in vitro culture system of human keratinocyte and melanocyte induces the biologic process of terminal differentiation of keratinocytes and inhibits proliferation of keratinoytes and melanocytes in a dose-dependent manner.
Calcitriol
;
Cholecalciferol*
;
Foreskin
;
Humans*
;
Keratinocytes*
;
Melanocytes*
;
Skin
;
Tics
;
Vitamin D
;
Vitamin E
;
Vitamins*
9.Expression of Cell Adhesion Molecules -CD44H and CD44v6- in Colorectal Carcinoma.
Dae Cheol KIM ; Seo Hee RHA ; Jin Sook JEONG ; Sook Hee HONG
Korean Journal of Pathology 1998;32(9):655-662
During tumor progression, a subset of cells acquires metastatic properties, presumably through a series of genetic alterations. As the result, cells detach from the primary tumor, penetrate the basement membrane and invade the adjacent structures including lymph and blood vessels. Loss of adhesive functions and gain of new adhesive functions are thought to play a crucial role in this metastatic cascade. Since tumor metastasis is the principle cause of death for cancer patients including colon cancer, there is a consensus that a search for tools that allow effective assessment of the metastatic potential of tumors is a prime goal for cancer research. An immunohistochemical study of cell adhesion molecules, CD44H and its variant CD44v6, was done to evaluate their relationship with known prognostic factors related to the progression and metastasis of colorectal carcinoma in 94 cases of colorectal carcinoma tissues. The results were as follows. The CD44H expression was detected in 90 (95.7%) and CD44v6 in 53 (56.4%) out of 94 cases of colorectal carcinoma, and the CD44H was overexpressed in tumor tissue more than in normal mucosa in 62% of the cases. The expression rates of both protein were not significantly correlated with age and sex of the patients, invasion depth, lymph node metastasis, tumor differentiation, and tumor site. The coexpression of CD44H and CD44v6 in tumor was significant (p<0.05). The above results suggest that overexpression of CD44H and loss of function to control the alternative splicing of CD44 mRNA resulting in CD44v6 expression and alteration of adhesive function are closely associated with tumorigenesis of the colorectum.
Adhesives
;
Alternative Splicing
;
Basement Membrane
;
Blood Vessels
;
Carcinogenesis
;
Cause of Death
;
Cell Adhesion Molecules*
;
Cell Adhesion*
;
Colonic Neoplasms
;
Colorectal Neoplasms*
;
Consensus
;
Humans
;
Lymph Nodes
;
Mucous Membrane
;
Neoplasm Metastasis
;
Prognosis
;
RNA, Messenger
10.Expression Pattern and Prognostic Correlation of BAG - 1 Protein in Breast Cancer.
Se Hoon CHO ; Dae Young LEE ; Byung Jin KIM ; Sook Hee HONG
Journal of the Korean Cancer Association 2000;32(1):60-67
PURPOSE: The objective of this study was to understand the expression of BAG-1 in the human breast cancer. MATERIALS AND METHODS: We studied its expression in one hundred and thirteen patients diagnosed with breast cancer in Dong-A university hospital between 1992 and 1996 by performing immunohistochemical staining with BAG-1 monoclonal antibody. RESULTS: Of the 113 breast carcinoma examined, 62.0% were positive for BAG-1 cyto- plasmic expression, 28.0% were positive for nuclear BAG-1 expression and 9.7% were positive for both BAG-1 cytoplasmic and nuclear expression. The higher histologic grade was correlated with the higher cytoplasmic expression (p<0.05). Except for histologic grade, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, menopausal status, metastatic status of the axillary lymh nodes, cathepsin-D, p53, C-erbB-2, DNA ploidy, S-phase fraction, PCNA (proliferating cell nuclear antigen). CONCLUSION: The high histologic grade was found to correlate with positive BAG-1 cyto- plasmic staining which did not correlate with conventional prognostic factors. Our data indicate that furthermore investigation is warranted to define the role of BAG-1 as an meaningful prognostic factor in patients with newly diagnosed breast cancer.
Breast Neoplasms*
;
Breast*
;
Cytoplasm
;
DNA
;
Humans
;
Ploidies
;
Proliferating Cell Nuclear Antigen