An endodermal sinus tumor is a malignant germ cell tumor that usually arises in the gonads, but on rare occasion occurs in extragonadal locations. Our case was that of a 3 year old girl who complained of a rapid growing orbital mass. On histologic examination it revealed the typical picture of an endodermal sinus tumor and it also disclosed a positive reaction for alphafetoprotein using an immunoperoxidase technique. An orbital exenteration was performed followed by chemotheraphy, but the patient died 5 months after the onset of the disease.

In order to find a highly efficient compound against Clonorchis infection, the anthelmintic activity of disophenol, Tremerad (SYD-230), dithiazanine iodide, dehydroemetine-late-release tablets(RO 1-9334/20), niridazole (Ambilhar), hexachlorophene (G-11), Hetol(1, 4-bis-trichloromethylbenzol) and Bilevon (niclofolan) was tested against Clonorchis sinensis experimentally infected rabbits. All drugs showed a progressive increase in efficacy as the dose rate. They were highly efficient against Clonorchis infection if sufficiently high, potentially toxic doses were given. The efficacy was evaluated by the number of detected worms with vital condition at autopsy after the treatment with above drugs. The high efficacy was observed at the following dose rates of each drugs, i.e. disophenol at a single dose of 30 mg/kg, Tremerad at the daily dose of 200 mg/kg for 10 consecutive days, dithiazanine iodide at the daily dose of 50 mg/kg for 6 consecutive days, dehydroemetine at the daily dose of 10 mg/kg for 10 consecutive days, hexachlorophene at the daily dose of 20 mg/kg for 10 to 15 consecutive days, Hetol at the daily doses from 50 to 100 mg/kg for 5 to 10 consecutive days, and Bilevon at a single dose of 8 mg/kg. Moderate effectiveness was shown in niridazole at the dose of 25 mg/kg for 10 days medication. The use of these anthelmintics for the clinical treatment of Clonorchis sinensis infection is discussed.
parasitology-helminth-trematoda ; chemotherapy-Clonorchis sinensis ; clonorchiasis-rabbit ; disophenol ; Tremerad (SYD-230) ; dithiazanine iodide ; dehydroemetine-late-release tablets(RO 1-9334/20) ; niridazole (Ambilhar) ; hexachlorophene (G-11) ; Hetol(1, 4-bis-trichloromethylbenxol) ; Bilevon (niclofolan)

PURPOSE: To evaluate the anatomical difference between the dominant and nondominant eyes in healthy, young adults by measuring macular, peripapillary retinal nerve fiber layer (PRNFL), and macular ganglion cell layer (MGCL) thicknesses. METHODS: Two hundred healthy adults were recruited and assessed for ocular dominance using 'a hole in the card test'. PRNFL, macular and MGCL thicknesses of both eyes were measured using spectral domain optical coherence tomography (OCT). RESULTS: There were no statistically significant differences for average thicknesses of MGCL in each of the six areas between the dominant and nondominant eyes. No difference was observed between temporal, inferior, average PRNFL thickness and macular thickness in dominant and nondominant eyes. CONCLUSIONS: There was no intraocular anatomical difference between the dominant and nondominant eyes in healthy, young adults.
Adult ; Dominance, Ocular ; Ganglion Cysts ; Humans ; Nerve Fibers ; Retinaldehyde ; Tomography, Optical Coherence ; Young Adult

In present study, the mechanism for oxygen-glucose deprivation -induced [3H]gamma-aminobutyric acid (GABA) from cerebral cortex slices of the rat was examined. Deprivation of oxygen and glucose(OGD) from Mg2+-free artificial cerebrospinal fluid, induced significant release of [3H]GABA (7.4+/-0.6% of total tissue content) from cerebral cortex slices. OGD-induced release of [3H]GABA was significantly attenuated by tetrodotoxin(TTX)(1 micrometer), Mg2+(1.2 mM), MK-801(10 micrometer), ketamine(10 micrometer), N-methyl-D-aspartate(NMDA) receptor antagonists, (DNQX)(30 micrometer), and 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX)(30 micrometer), kainate/AMPA receptor antagonists, or 6-nitro-7-sulphamoyl-benzo[f]quinoxaline-2, 3-dione(NBQX)(10 micrometer), a selective AMPA receptor blocker. OGD-evoked [3H]GABA release was attenuated by (NG-nitro-L-arginine methyl ester(L-NAME) and 7-nitronidazole, nitric oxide synthase inhibitors, and methylene blue, potentiated by zaprinast, a cGMP phosphodiesterase inhibitor. OGD-induced release of [3H]GABA was inhibited by nipecotic acid, a selective neuronal GABA transporter blocker, and potentiated by DL-2.4-diamino-n-butyric acid(DABA), a neuronal and glial GABA transporter blocker. Dantrolene (30 micrometer) and 1,2-bis (2-aminophenoxy)-ethane-N, N, N', N'-tetraacetic acid tetrakis (acetoxymethyl) ester(BAPTA-AM)(30 micrometer), inhibitors of intracellular Ca2+ release, verapamil(5 micrometer), omega-conotoxinGVIA(100 nM) and omega-agatoxinIVA(100 nM), inhibitors of voltage-dependent Ca2+ channels, significantly attenuated the OGD-induced release of [3H]GABA. These results suggest that glutamate is involved in OGD-evoked [3H]GABA release, and this release is achieved by Ca2+-dependent exocytosis and reversal of transporters, and can be modulated by various neuronal mechanisms.
Animals ; Cerebral Cortex* ; Cerebrospinal Fluid ; Dantrolene ; Exocytosis ; gamma-Aminobutyric Acid ; Glutamic Acid ; Methylene Blue ; Neurons ; Nitric Oxide Synthase ; Oxygen ; Rats* ; Receptors, AMPA

No abstract available.
Diskectomy*

PURPOSE: To compare the clinical features according to the presence of anisometropia in refractive accommodative esotropia patients. METHODS: Forty-five refractive accommodative esotropia patients were divided into 2 groups : patients who had anisometropia of more than 1.00D (anisometropia group), and patients who had anisometropia of less than 1.00D (isometropia group). Age at onset, age when glasses were first worn, the initial and final angle of esotropia with or without hyperopic correction, the recovery time to orthophoria after hyperopic correction, the degree of stereoacuity and the frequency of amblyopia, the prevalence of deterioration, and the ratio of accommodative-convergence to accommodation were retrospectively reviewed. RESULTS: There were no statistical differences between the 2 groups in the frequency of amblyopia, the prevalence of deterioration, and the ratio of accommodative-convergence to accommodation at the initial and final visit. The angles of deviation with hyperopic correction at the 1-month follow-up visit in the anisometropia group and the isometropia group were 8.80 +/- 5.63 PD for near, 8.67 +/- 5.42 PD for distance, and 4.54 +/- 6.59 PD for near 5.19 +/- 6.7 PD for distance, respectively; the difference was statistically significant (p = 0.042). The recovery time to orthophoria after hyperopic correction in patients associated with anisometropia was 2.20 +/- 1.01 months, significantly longer than 1.47 +/- 0.86 months in patients associated with isometropia (p = 0.017). CONCLUSIONS: In refractive accommodative esotropia patients associated with anisometropia, the recovery time to orthophoria after hyperopic correction was significantly prolonged but there were no statistical differences in other clinical manifestations.
Amblyopia ; Anisometropia ; Esotropia ; Eyeglasses ; Follow-Up Studies ; Glass ; Humans ; Prevalence ; Retrospective Studies

We studied the relationship between dermal mast cell proliferation and pruritus in patients with end stage of renal failure. Skin biopsies were taken from 21 patients undergoing hemodialysis in end stage of renal failure. As a control, 12 pruritic patients without any internai problem were u.d. During the hemodialysis, 13 patient ha<) pruritus. Serum PTH levels were measured by radioimmunoassay. We have thought that the cause of pruritus in patients undergoing hemodialysis is related with dermal mast cell proliferation and a release of histamine. The results were as follows .' 1. Significantly larger numbers of dermal mast cells were found in hemodialysis patients than in the control (p<0.001). 2. Significantly larger mumbers of dermal mast cells were found in prnritic patients than in the non pruritic patients among hemodialysis patients (p<0.01). 3. There was no clear relationship between dermal mast cell proliferation and duration of hemodialysis or seum level of parathyroid hormone.
Biopsy ; Histamine ; Humans ; Mast Cells* ; Parathyroid Hormone ; Pruritus ; Radioimmunoassay ; Renal Dialysis ; Renal Insufficiency* ; Skin

PURPOSE: To report a case of periorbital infantile capillary hemangioma treated with propranolol as a single therapy. CASE SUMMARY: A 3-month-old girl with a growing red-purple mass on the right lower eyelid visited our clinic. The patient was diagnosed with capillary hemagioma by imaging studies. The mass had grown rapidly, and the visual axis was obscured in the follow-up. Oral propranolol therapy was initiated at a starting dose of 0.17 mg/kg at 8-hour intervals. After 2 doses, the propranolol was doubled, and after another 2 doses, the daily dose of 0.67 mg/kg divided into 3 was maintained. Three days after the initiation of the treatment, the color of the hemangioma had changed from red-purple to light purple, and the hemangioma had softened. The hemangioma continued to respond well with no side effects in the following 10 months. CONCLUSIONS: The authors suggest that oral propranolol treatment as a possibility of an effective and safe option for the vision-threatening periorbital capillary hemangioma as a single therapy.
Axis, Cervical Vertebra ; Capillaries ; Eyelids ; Follow-Up Studies ; Hemangioma ; Hemangioma, Capillary ; Humans ; Infant ; Light ; Propranolol

PURPOSE: To report a case of periorbital infantile capillary hemangioma treated with propranolol as a single therapy. CASE SUMMARY: A 3-month-old girl with a growing red-purple mass on the right lower eyelid visited our clinic. The patient was diagnosed with capillary hemagioma by imaging studies. The mass had grown rapidly, and the visual axis was obscured in the follow-up. Oral propranolol therapy was initiated at a starting dose of 0.17 mg/kg at 8-hour intervals. After 2 doses, the propranolol was doubled, and after another 2 doses, the daily dose of 0.67 mg/kg divided into 3 was maintained. Three days after the initiation of the treatment, the color of the hemangioma had changed from red-purple to light purple, and the hemangioma had softened. The hemangioma continued to respond well with no side effects in the following 10 months. CONCLUSIONS: The authors suggest that oral propranolol treatment as a possibility of an effective and safe option for the vision-threatening periorbital capillary hemangioma as a single therapy.
Axis, Cervical Vertebra ; Capillaries ; Eyelids ; Follow-Up Studies ; Hemangioma ; Hemangioma, Capillary ; Humans ; Infant ; Light ; Propranolol

No abstract available.
Colon* ; Diverticulitis*