BACKGROUND: Psoriasis is a disease of unknown etiology. Disturbances in lipid metabolism have been suggested as a possible pathogenetic mechanism. OBJECTIVE: The study was performed to investigate the blood lipid, lipoprotein and apolipo-protein levels and their difference according to family history in Korean psoriasis patients. METHODS: Blood samples from seventy three psoriasis patients and twenty three normal persons were measured for total ciolesterol(TC), VLDL-cholesterol(VLDL-C), LDL-cholesterol(LDL-C), HDL-cholesterol(HDL-C), lipoprotein(a) (LPA), triglyceride(TG), apolipoprotein A-I(APO-AI), and apolipoprotein B(AFO-B). Psoriasis patients were divided according to their family history of psoriasis. RESULTS: Compared to ccntrols, TC, LDL-C, LPA, TG, APO-B were significantly elevated in psoriasis patients. Mean varues of LPA and APO-B in psoriasis group were above normal range. VLDL-C were significasitly elevated only in female patients. There was a tendency for psoriasis patients with family history to have higher values than those without family history. CONCLUSION: TC, LDL-C, L,PA, TG, APO-B was increased in psoriasis, especially in the patients with family history, cornpared to control. It is recommended that we must pay attention to the possible risk for the development of cardiac or cerebral vascular disease in psoriasis patients, especially in the presence of family history of psoriasis.
Apolipoproteins ; Apolipoproteins B ; Female ; Humans ; Lipid Metabolism ; Lipoprotein(a) ; Lipoproteins* ; Psoriasis* ; Reference Values ; Vascular Diseases

BACKGROUND: Oral etretinate treatment is associated with the changes in serum lipid concentration and the elevation of serum liver enzymes. In Korea, chronic degenerative diseases like diabetes and hypertension are increasing and the prevalences of HBsAg and chronic liver diseases are much higher than those in western countries. Therefore these changes in serum lipids and liver enzymes during etretinate treatrment are important in Korea as risk factors for atherosclerosis and aggravation of preexisting liver diseases. OBJECTIVE: We tried to observe the sequential pattern, frequency, severity, and relationship between pretreatment value and posttreatment values in the changes of serum lipids and liver enzymes in patients with psoriasis luring etretinate treatment. METHODS: Fourty-one patients with psoriasis were studied during etretinate treatment with the starting dose of 0.5-1.0mg/kg/day. The levels of serum triglyceride, serum cholesterol, HDL-cholesterol, and sGOT, sGPT was repeatedly determined until the 16th week of etretinate treatment. RESULTS: l. In serum triglyceride and cholesterol, the average of concentrations in each treatment period was usually higher than pretreatment value during the 16 weeks of treatment, but no sequential pattern of changes was observed 2. The number of patients with the maximum of posttreatment values higher than the normal limit were 12(29.3%) in triglyce side, 6(14.6%) in cholesterol, 0 in sGOT, and 5(12.5%) in sGPT. The number of patients with the minimum of posttreatment values lower than the normal limit were 15(36.6%) in HDL-cholesterol. 3. In serum cholesterol, patients with an abnormal pretreatment value are more prone to elevation above the normal limit duriing etretinate treatment than patients with a normal pretreatment value. CONCLUSION: In patients with psoriasis the increases in serum triglyceride, serum cholesterol, sGOT, sGPT and the decrease in HDL-cholesterol were occurred frequently during etretinate treatment. Therefore monitoring of serum lipid concentration and serum liver enzyme levels on a regular basis during etretinate treatment is essential for its safe use in patients with psoriasis, es- pecially in cases of long term etretinate treatment.
Acitretin* ; Alanine Transaminase ; Aspartate Aminotransferases ; Atherosclerosis ; Cholesterol ; Etretinate* ; Hepatitis B Surface Antigens ; Humans ; Hypertension ; Korea ; Liver Diseases ; Liver* ; Prevalence ; Psoriasis* ; Risk Factors ; Triglycerides

Neonatal lupus erythematosus(NLE) is a rare syndrome occuring in neonates with transplacentally acquired maternal autoantibodies, in particular anti-Ro, anti-La or anti-U1RNP. We report a case of NLE in a 50-day-old male neonate born to a systemic lupus erythematosus-mother with anti-U1RNP autoantibodies; on a review, there have been 8 cases of NLE reported in Korean literature.
Autoantibodies ; Humans ; Infant, Newborn ; Male

BACKGROUND: Congenital hypotrichosis is a non-specific, descriptive term for structural abnormalities of hairs showing variable clinical features. We recently have encountered a group of eleven patients exhibiting abnormal hairs showing similar patterns. OBJECTIVES: Our purpose was to clarify the entity of this structural hair disorder. METHODS: Dermatologic examination with routine histopathology, trichograms along with scanning electron-microscopic examination and laboratory studies were undertaken. RESULTS: All cases except one were female, and hair abnormalities had developed at birth or within a year. Diffuse distribution of thin, sparse, soft and hypopigmented hairs were noticed. On hair mounts, four patients showed tapering of roots. The majority of the patients exhibited cuticular changes, as well as pitting and longitudinal axial twisting by scanning electron-microscopic examination; one case demonstrated trichorrhexis nodosa, and another, trans-verse fracture. CONCLUSION: Although our cases bear some similar points with woolly hair, some differences were noted between this type of congenital hypotrichosis and other previously described syndromes.
Female ; Hair ; Humans ; Hypotrichosis* ; Parturition

BACKGROUND: The elastic properties of skin may be useful indicators of cutaneous diseases and skin aging. OBJECTIVE: The purpose of this study is to obtain the normal range of skin elastic properties according to anatomical sites in normal Korean individuals and to show the differences among them. METHODS: Eleven different anatomical sites were measured in 41 healthy volunteers (20 males and 21 females) with a measuring device, Dermaflex-A . Tensile distensibility(TD), elasticity(E), and hysteresis(H) were recorded. RESULTS: TD was decreased in the distal portions (e.g. 2.30 +/- 0.35 in the arm vs 1.62 +/- 0.30 in the palm in males) and in the sites where the subcutaneous tissue was thin (e.g. 3.08 +/- 0.60 in the abdomen vs 1.20 +/- 0.44 in the medial malleolus in males). E was also decreased in the distal portions (e.g. 82.3 +/- 8.5 in arm vs 51.2 +/- 11.1 in the palm in males) and in the sites where the subcutaneous tissue was thin (e.g. 89.3 +/- 8.3 in the abdomen vs 58.8 +/- 13.8 in the medial melleolus in males). In contrast, H had greater individual variations and it showed no definite tendency according to sites. TD and E were generally greater in males than in females, and there were some significant differences between sexes according to sites. CONCLUSION: Cutaneous elastic properties varied according to anatomical sites and sexes. This feature must be considered in future studies measuring elastic properties, such as aging experiments.
Abdomen ; Aging ; Arm ; Elasticity ; Female ; Healthy Volunteers ; Humans ; Male ; Reference Values ; Skin Aging ; Skin* ; Subcutaneous Tissue

Desmoplastic trichoepithelioma is a rare benign adnexal tumor of hair follicle origin. Clinically it is solitary, asymptomatic, white or yellowish and the center is frequently depressed, but not ulcerated. The three critical histologic features are narrow strands of tumor cells, keratinous cysts, and desmoplastic stroma. We present a case of desmoplastic trichoepithelioma in a 61-year-old man who had an asymptomatic, firm, annular nodule with a depressed center and an elevated border on the nose.
Hair Follicle ; Humans ; Middle Aged ; Nose ; Ulcer

OBJECTIVES: Worker's health is an important index used to evaluate working conditions and to prioritize prevention policies. However, this index has never before been calculated in Korea. The purpose of this study was to calculate the prevalence of health problems caused by work related sickness absences using the second Korean Working Condition Survey (KWCS) conducted in 2010. METHODS: The second KWCS was conducted from June to October 2010 as a household survey for employed workers. The work related sickness absence rate was estimated using gender, age, business size, occupational status, level of education, and level of income. A logistic regression was performed in order to evaluate the relationship of the work related sickness absence with general characteristics and work-related conditions. RESULTS: The rate of work related sickness absence was 1.8(+/-0.2)% for all workers, with 6.0(+/-0.3)% of it being in agriculture, forestry, and fishing, and 2.2(+/-0.5)% in manufacturing. Musculoskeletal disorders (MSD) were the most common work related disorder [1.01(+/-0.12)%], followed by psychiatric disorders [0.18(+/-0.05)%], and respiratory disorders [0.14(+/-0.04)%]. The highest odds ratio (OR) for the work related sickness absence rate was in self-employed workers with employees (OR=2.23, 95%CI=1.05~4.74). CONCLUSIONS: The work related sickness absence rate for all workers, both self-employed and employed, including agriculture, forestry and fishing workers, and wholesale and retail trade workers was 1.8(+/-0.2)%. Because the KWCS was based on a self-reported questionnaire survey, this figure might be overestimated. In addition, it might omit chronic occupational disease and death cases.
Agriculture ; Commerce ; Employment ; Family Characteristics ; Forestry ; Korea ; Logistic Models ; Occupational Diseases ; Odds Ratio ; Prevalence ; Questionnaires

We report a case with an isolated single coronary artery originating from the ascending aorta, which to our knowledge has never been described before. A 51-year-old man presented for evaluation of atypical chest pain, suffering from a short resting chest pain for 3 days. However, serial electrocardiogram showed no change during chest pain. Cardiac enzymes such as CK-MB, Troponin-I, and myoglobin were within normal limit. Aortography and coronary angiography revealed a single coronary artery originating from the postero-lateral wall of the ascending aorta above the left coronary siuns. However, this anomaly was not of clinical significance based on the atypical nature of the chest pain, negative exercise echocardiography and an absence of obstruction of the coronary artery.
Aorta* ; Aortography ; Chest Pain ; Coronary Angiography ; Coronary Sinus* ; Coronary Vessel Anomalies ; Coronary Vessels* ; Echocardiography ; Electrocardiography ; Humans ; Middle Aged ; Myoglobin ; Troponin I

PURPOSE: This study was performed to evaluate the impact of microvessel density (MVD), a reflection of tumor angiogenesis, and microvascular invasion (MVI) on the prognosis of patients with renal cell carcinoma (RCC). MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections of RCC from 81 patients who had undergone radical nephrectomy were stained immunohistochemically for CD34, which decorate endothelial cells, in order to assess MVD and MVI. The immunostaining results of MVD and MVI were compared with the clinicopathological variables. RESULTS: Twenty-two patients had either synchronous or metachronous metastases and fourteen patients died during the follow-up. MVD was significantly correlated with only metastasis (synchronous or metachronous; p=0.020). MVI was significantly correlated with tumor size (p=0.005), TNM stage (p<0.001), T stage (p<0.001), M stage (p=0.001), and metastasis (synchronous or metachronous; p=0.007). MVD was not significantly associated with MVI (p=0.232). The survival rate of patients with higher MVD or MVI-positive tumors was significantly lower than that of patients with lower MVD or MVI-negative tumors, respectively (p<0.0001, p=0.0002). Multivariate analyses indicated that tumor size, M stage and MVI were independent prognostic factors for cancer-specific survival. MVD was not an independent factor. CONCLUSIONS: MVD and MVI were associated with metastasis and a worse prognosis in RCC, which suggests that tumor angiogenesis and MVI may play an important role in the progression of RCC. MVI was an independent prognostic factor for cancer-specific survival.
Carcinoma, Renal Cell* ; Endothelial Cells ; Follow-Up Studies ; Humans ; Microvessels ; Multivariate Analysis ; Neoplasm Metastasis ; Nephrectomy ; Prognosis ; Survival Rate ; Veins

BACKGROUND: The need for using sunscreen is increasing today, but we know little about the effect of sunscreens on the skin of Korean people. OBJECTIVE: We tried to estimate and compare the SPF of 8% homomenthyl salicylate lotion, which was recommended as the control in SPF experiments by the FDA, USA, in Koreans according to different light sources. METHODS: After application of 8% homomenthyl salicylate lotion to the back, 33 men of the third decade were irradiated by xenon arc solar simulator or by fluorescent sunlamp, We estimated the SPF of them 24 hours later. RESULTS: The SPF of 8% homomenthyl salicylate lotion was 4.8+/-0.8 with the solar simulator, 2.7+/-0.6 with the fluorescent sunlamp. CONCLUSION: We confimed that the SPF of 8% homomenthyl salicylate lotion with xenon arc solar simulator can be used as a control value in Koreans, and found out that the SPF with the fluorescent sunlamp was significantly lower than that with the xenon arc lamp. So it should be taken into consideration that differences of SPF according to light sources exists in studying sunscreens.
Humans ; Male ; Skin ; Solar System* ; Sun Protection Factor* ; Sunscreening Agents ; Xenon