No abstract available.
Leukemia*

OBJECTIVE: The aim of this study was to assess the relationship between disease progression and expression of c-erbB-2 and S-100 protein positive dendritic cells in Cervical cancer. STUDY DESIGN: Tissues were analyzed from 100 patients. Each of them had invasive carcinoma(44), microinvasive(12), CIS(33), CIN(II) before treatment, c-erbB-2 oncoprotein expression and S-100 protein positive dendritic cell were confirmed by immunohistochemical staining. (Avidin-biotin complex method) RESULTS: C-erbB-2 immunostaining was significantly associated with disease progression (p<0.05). In case of CIN I, there was not noted stained specimen but in case of invasive carcinoma, 24 cases of stained specimen were noted. S-100 protein positive dendritic cell was not associated with disease progression of cervical carcinoma.(p>0.05) CONCLUSIONS: According to our results, c-erbB-2 is possible factor in Carcinogenesis of cervical carcinoma with progression of it. and S-100 protein positive dendritic cell was not associated with disease progression of cervical carcinoma.
Carcinogenesis ; Carcinoma, Squamous Cell* ; Cervix Uteri* ; Dendritic Cells* ; Disease Progression ; Female ; Humans ; S100 Proteins* ; Uterine Cervical Neoplasms

Spinal cord infarction as a complication of spine surgery occurs rarely. Herein, a case of spinal cord infarction, which developed in a 69 year old woman following posterior decompression and internal fixation for a T11 bursting fracture, is descirbed. The anesthetic induction and intraoperative course were uneventful, except at the end of the procedure, where her blood pressure suddenly dropped from 130/90 to 90/60 mmHg. The patient was aggressively treated with a transfusion and vasopressor, the blood pressure then returned to its usual value within 10 minutes. However, during a physical examination in the recovery room, the patient was found to have flaccid lower limbs, with impaired sensory function below the T8 level. Her cord diameter had increased, and a high signal lesion was observed within the thoracic spinal cord, from T9 to T12 level on T2-weighted MR images, which was diagnosing as a spinal cord infarction, was and showed no improvement despite the immediate and aggressive treatment.
Aged ; Blood Pressure ; Decompression ; Female ; Humans ; Infarction* ; Lower Extremity ; Physical Examination ; Recovery Room ; Sensation ; Spinal Cord* ; Spine*

BACKGROUND: Bronchial anthracofibrosis (BAF) is a dark black or brown pigmentation of multiple large bronchi associated with a fibrotic stenosis or obliteration that is incidentally found during a diagnostic bronchoscopy. Some reporters have suggested endobronchial tuberculosis or tuberculous lymphadenitis as a possible cause of BAF. However, some BAF patients do not have any medical history of tuberculosis. The aim of this study was to elucidate the clinical features of simple BAF patients, which were not associated with tuberculosis. METHODS: We reviewed the patients' charts retrospectively and interviewed all BAF patients who were followed up for 1 year or more. Among the 114 BAF patients, 43 patents (38 %) had no associated tuberculosis, cancer and pneumoconiosis. The clinical characteristics, radiological findings and associated pulmonary diseases of these patients were evaluated. RESULTS: Most patients were non-smokers, old aged, housewifes who resided in a farming village. The common respiratory symptoms were dyspnea, cough and hemoptysis. The predominant X-ray findings were a multiple bronchial wall thickening(89%), bronchial narrowing or atelectasis (76%) and a mediastinal lymph node enlargement with/without calcification (78%). Pulmonary function test usually showed mild obstructive ventilatory abnormalities but no patient showed a restrictive ventilatory pattern and the patients were frequently affected with chronic bronchitis(51%), post-obstructive pneumonia(40%) and chronic asthma(4%). CONCLUSION: Because BAF is frequently associated with chronic bronchitis and obstructive pneumonia as well as tuberculosis, a careful clinical evaluation and accurate differential diagnosis is more essential than empirical anti-tuberculous medication.
Diagnosis, Differential ; Pneumoconiosis

Acoustic pharyngometry is a relatively new noninvasive method that quantifies geometrically complexed pharyngeal dimensions. Our study aimed to investigate the predictability and usefulness of acoustic pharyngometry in diagnosis of obstructive sleep apnea (OSA), and we developed a prospective clinical trial in 16 subjects without apnea and 54 subjects with apnea. All seventy subjects received polysomnography (PSG) to assess the sleep architecture, including breathing and the degree of apnea hypopnea index. Acoustic pharyngometry was performed in four body positions (sitting, supine, right and left lateral) while awake with tidal breathing in addition to morphometric measurements (Kushida index) of oral cavity. This study shows that the cross-sectional area and volume of the upper airway is smaller in the supine position than any other positions. As well, the oropharyngeal junction area of the supine position is the most predictive parameter to discriminate between subjects with or without OSA. Acoustic pharyngometry can be a clinically useful tool for localizing the narrowed portion of the upper airway and predicting obstructive sleep apnea.
*Acoustics ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Mouth/*pathology ; Pharynx/*pathology ; Polysomnography ; Predictive Value of Tests ; Prospective Studies ; Sleep Apnea, Obstructive/*pathology ; Supine Position

No abstract available.
Choanal Atresia* ; Microphthalmos*

PURPOSE: The mortality and morbidity rate after pancreaticoduodenectomy (PD) is still high, although the operative techniques and skills and the perioperative care has been improved. The incidence of PD for benign disease is 5~20%. The aim of this study is to determine the factors that differentiate between the benign group and the malignant group by comparing the clinical manifestations, and we studied the safety of performing PD for benign diseases by observing the early and late postoperative complications. METHODS: We retrospectively studied 124 patients who had been diagnosed with benign or malignant pancreatic diseases and who underwent PD between April 1995 and December 2005. We divided the patients into two groups, i.e., the benign group (20) and the malignant group (104), to compare their clinical characteristics and postoperative outcomes. Result: Chronic pancreatitis was the most common disease (35%) in the benign group and distal CBD cancer was the most common disease (40.4%) in the malignant group. Jaundice, weight loss, and elevation of CA 19-9 were more frequent in the malignant group than in the benign group (p<0.05). There were no statistical differences in the mortality rate (10.0% vs 6.7%), reoperation rate (5.0% vs 4.8%), hospital stays (27.1 days vs 24.0 days), early complications (30.0% vs 44.6%) and late complications (22.2% vs 26.4%) between the two groups. There were no mortality and newly developed malignancy during 33.4 months of follow-up period in benign group. CONCLUSION: On the preoperative evaluation, jaundice, weight loss, and elevation of CA 19-9 were more frequent in the malignant group. The postoperative early and late complications showed no difference between the two groups and complication rate was generally favorable. Thus, PD can be performed safely for benign diseases that cannot be treated in a conservative fashion and also for other clinically suspicious malignant diseases.
Follow-Up Studies ; Humans ; Incidence ; Jaundice ; Length of Stay ; Mortality ; Pancreatic Diseases ; Pancreaticoduodenectomy* ; Pancreatitis, Chronic ; Perioperative Care ; Postoperative Complications ; Reoperation ; Retrospective Studies ; Weight Loss

The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many types of tumor tissues. Trifluoperazine (TFP), a phenothiazine class of antipsychotics, restored serum-induced Egr-1 expression in several cancer cell lines. We investigated the effect of Egr-1 expression on the TFP-induced inhibition of cell growth. Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells. Our results suggest that antipsychotics TFP exhibits antiproliferative activity through up-regulation of Egr-1.
Cell Cycle ; Cell Proliferation/drug effects ; Cyclin D1/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Gene Expression ; Glioma/*metabolism ; Humans ; Immediate-Early Proteins/genetics/*metabolism ; Promoter Regions (Genetics)/drug effects ; Research Support, Non-U.S. Gov't ; Transcription Factors/genetics/*metabolism ; Trifluoperazine/*pharmacology ; Tumor Cells, Cultured

BACKGROUND: Diabetes Mellitus has been known as a multisystemic disorder for a long time. An association between diabetes and hearing loss was first postulated in the one case report published by Jordao in 1857. The typical hearing loss from diabetes is a progressive and bilateral sensorineural deficit that predominantly occurs in the high frequency and in the elderly patients. OBJECTIVES: The purpose of this study was to investigate the morphological changes of cochlear hair cells in the insulin-dependent diabetes mellitus induced by Streptozotocin. MATERIALS AND METHODS: Thirty two rats were used for this study and divided into control and diabetic group. Furthermore each group was subdivided into 4 weeks, 8 weeks, 12 weeks and 16 weeks group. All experimental animal were put in the same environmental condition. Insulin-dependent diabetes mellitus was induced by intravenous injection of Streptozotocin (65 mg/kg of body weight). Hair cell loss and their ultrastructural changes were observed with phase contrast light microscope and transmission electron microscope. CONCLUSION: The results of this study suggest that metabolic change of diabetes mellitus may affect the cochlear hair cells.
Aged ; Animals ; Diabetes Mellitus ; Diabetes Mellitus, Type 1 ; Hair* ; Hearing Loss ; Humans ; Injections, Intravenous ; Rats* ; Streptozocin

Nasopharyngeal and oropharyngeal tuberculosis is a rare disease. The authors have recently experienced a case of a 40-year-old woman who had been presented with throat discomfort for 3 months. Her medical history showed no pulmonary tuberculosis, but the physical examination revealed isolated granulomatous lesion on the nasopharynx and an isolated ulcerated granulomatous lesion on the posterior wall between nasopharynx and oropharynx (naso-oropharynx). Biopsies from the both sides showed tuberculoid granuloma with multinucleated giant cells, caseous necrosis, and chronic granulomatous infla-mmation. A trial of anti-tuberculous chemotherapy reduced the size and produced gradual healing of the lesion in seven months. We report this case with a review of literature.
Adult ; Biopsy ; Drug Therapy ; Female ; Giant Cells ; Granuloma ; Humans ; Nasopharynx ; Necrosis ; Oropharynx ; Pharynx ; Physical Examination ; Rare Diseases ; Tuberculosis* ; Tuberculosis, Pulmonary ; Ulcer