1.Distal Radius Osteosarcoma.
Won Seok SONG ; Ho Hyun WON ; Jeong Dong LEE ; Dae Geun JEON
The Journal of the Korean Bone and Joint Tumor Society 2010;16(2):55-61
PURPOSE: We analyzed the clinical outcome of osteosarcoma developed in distal radius and the effect of delayed treatment on prognosis. MATERIALS AND METHODS: Twelve patients with distal radius osteosarcoma were analysed. We categorized patients into two groups of standard treatment or non-standard treatment. The patients of standard treatment group are all stage IIB and non-standard treatment group includes five stage IIB and one stage III. RESULTS: Five-year overall survival and disease-free survival rates of standard treatment group were 100% and 83%. Five-year overall survival rate of non-standard treatment group was 44%. Between two group, there are differences in age, tumor size, surgery type, symptom duration. CONCLUSION: Distal radius osteosarcoma have good prognosis than other extremity osteosarcoma. Survival rate of non-standard treatment group were lower than standard treatment group. Although the prognosis of non standard treatment group is poorer, the duration till death was longer than that of other sites with similar condition. Further multi-institutional study should be needed.
Disease-Free Survival
;
Extremities
;
Humans
;
Osteosarcoma
;
Prognosis
;
Radius
;
Survival Rate
2.Primary Amenorrhea in a Woman with 45, XO/46, XX/47, XXX Mosaicism A Case Report.
Ji Hye JEON ; Myong Seon LEE ; Jeong Dae KIM ; Do Geun LEE ; Hong Lyon JEE ; Jung Geun KIM
Korean Journal of Obstetrics and Gynecology 1997;40(2):446-450
There are many variant forms in Turner's syndrome which is characterized by female phenotype, short height, primary amenorrhea, infertility, abnormal secondary sexual development, and mental retardation. Among these 45,XO/46,XX/47,XXX form is known as rare variant of Turner's syndrome. 45,XO/46,XX/47,XXX mosaicism is characterized by normal height, possibility of normal sexual development, menstrual/pregnancy history and normal intelligence. We report a cse of 45,XO/46,XX/47,XXX Turner's syndrome associated with primary amenorrhea in 17-year old Korean female.
Adolescent
;
Amenorrhea*
;
Female
;
Humans
;
Infertility
;
Intellectual Disability
;
Intelligence
;
Mosaicism*
;
Phenotype
;
Sexual Development
;
Turner Syndrome
3.HRCT Findings of Bleomycin-Related Lung Toxicity: A Report of 2 Case.
Jeong Geun YI ; Won Ho JANG ; Dae Young YOON ; Sang Hoon BAE
Journal of the Korean Radiological Society 1997;36(1):83-86
Many drugs can result in a variety of pathologic reactions in the lung, especially the cytotoxic drugs. Amongcytotoxic drugs bleomycin is a prototype. Bleomycin-related pulmonary toxicity is usually known as dose-dependent and can be enhanced with concurrent oxygen therapy, irradiation, or other chemotherapeutic agents. The incidence of bleomycin-induced pulmonary toxicity has been reported as varying from 2 to 46%, and 1% of fatal lung disease. We describe the radiographic and HRCT findings of bleomycin-related pulmonary toxicity developed in two patients: one in ovarian teratocarcinoma, the other malignant lymphoma patient. Chest radiographs and HRCT of these patients showed ground-glass opacities, consolidation, linear and reticular opacities, and interlobular septal thickening. These abnormalities were bilateral, and symmetrical and were found predominantly in the area of mid-and lower-lung zone.
Bleomycin
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Humans
;
Incidence
;
Lung Diseases
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Lung*
;
Lymphoma
;
Oxygen
;
Radiography, Thoracic
;
Teratocarcinoma
4.Idiopathic Spinal Epidural Lipomatosis in a non-obese healthy man..
Yong Bin YIM ; Yong Jin JO ; Dae Seong KIM ; Dae Su JEONG ; Kyu Hyun PARK ; Geun Sung SONG ; Sang Ok NA
Journal of the Korean Neurological Association 1998;16(3):402-407
We report a non-obese patient suffering from spastic gait and right leg paresis caused by thoracic spinal cord compression secondary to spinal epidural lipomatosis. Although spinal epidural lipomatosis is most often associated with the administration of exogenous steroid or endogenous Cushing syndrome, obesity also has been reported as a possible cause. However, idiopathic(non-glucocorticoid induced) spinal epidural lipomatosis in non-obese healthy man is an extremely rare disease and dose not have any good explanation for the abnormal fat deposition in spinal epidural space. We recently experienced a patient with idiopathic thoracic epidural lipomatosis in whom MRI and histopathology established the specific diagnosis. With a case report, brief review of the disease including clinical feature, diagnostic procedure and therapeutic considerations is described.
Cushing Syndrome
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Diagnosis
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Epidural Space
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Gait Disorders, Neurologic
;
Humans
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Leg
;
Lipomatosis*
;
Magnetic Resonance Imaging
;
Obesity
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Paresis
;
Rare Diseases
;
Spinal Cord Compression
5.The Pathogenesis of Adenomyosis Through the Immunohistochemical Study with bcl-2 and MMP-9.
Myoung Seok HAN ; Geun A SONG ; Hyo Jeong JUN ; Dae Cheol KIM ; Jin Sook JEONG
Korean Journal of Obstetrics and Gynecology 2004;47(9):1714-1718
OBJECTIVE: To understand the pathogenesis of adenomyosis through the immunohistochemical staining with bcl-2 and matrix metalloproteinase-9 (MMP-9) antibody. METHODS: We selected 45 cases of adenomyosis among the uterine specimens that were extirpated surgically due to benign gynecologic problem. Immunohistochemical staining to the myometrial tissue was performed using anti-bcl-2 and anti-MMP-9 antibodies. Staining was qualitatively assessed in terms of extent and intensity. RESULTS: There were 32 cases of proliferative phase and 13 cases of secretory phase depending on the date of endometrium. Anti-bcl-2 stained 81.3% (26/32) compared with anti-MMP-9 stained 6.3% (2/32) in the glandular tissue of the proliferative phase (p<.001). In the secretory phase, anti-bcl-2 92.3% (12/13) and anti- MMP-9 7.7% (1/13) respectively (p<.001). In the stromal tissue of the proliferative phase, anti-bcl-2 stained 62.5% (20/32) compared with anti- MMP-9 stained 6.3% (2/32) (p<.001). In the secetory phase, anti-bcl-2 84.6% (11/13) and anti-MMP-9 15.4% (2/13) (p<.001). CONCLUSION: The adenomyosis may be developed from simple invagination and cellular proliferation of endometrial tissue, not caused by myometrial infiltration of endometrial tissue.
Adenomyosis*
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Antibodies
;
Cell Proliferation
;
Endometrium
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Female
;
Matrix Metalloproteinase 9
6.Ultrasonographic Findings of Mild and Very Mild Carpal Tunnel Syndrome.
Gi young PARK ; Jung ho BAE ; So young LEE ; Jeong seob OH ; Jeong Geun LIM ; Dae Gu SON
Journal of the Korean Academy of Rehabilitation Medicine 2008;32(1):67-72
OBJECTIVE: To assess the clinical usefulness of ultrasonography for the diagnosis of mild and very mild carpal tunnel syndrome. METHOD: Ultrasonographic evaluation was performed in 39 hands of 29 patients with mild and very mild carpal tunnel syndrome according to Bland's neurophysiologic grading scale. Controls included 41 hands of 34 subjects without electrophysiologic evidence of carpal tunnel syndrome. Ultrasonographic findings were evaluated quantitatively with regard to the cross-sectional area, the flattening ratio, the swelling ratio of the median nerve, and palmar displacement of the flexor retinaculum. The analysis of differences between controls and patients group were done by independent t-test. Cut-off values using receiver operation characteristic, were calculated. RESULTS: Patients had significantly increased cross sectional area and flattening ratio of the median nerve at proximal carpal area, palmar displacement of the flexor retinaculum at proximal carpal area. A critical value of equal or higher to 8.5 mm(2) for cross-sectional area at the pisiform level showed a sensitivity 79.5%, a specificity of 95.1%, which had most diagnostic value compared with the value of cross-sectional area at the distal radius level, flattening ratio at the pisiform level and palmar displacement. CONCLUSION: Ultrasonography was useful in the diagnosis of mild and very mild carpal tunnel syndrome.
Carpal Tunnel Syndrome
;
Displacement (Psychology)
;
Hand
;
Humans
;
Median Nerve
;
Radius
;
Sensitivity and Specificity
7.Relationship between Serum HBV DNA Levels and Liver Histology in Chronic Hepatitis B.
Jeong Ho HEO ; Jeong HEO ; Dae Sik KWON ; Jae Hyeon MOON ; Gwang Ha KIM ; Dae Hwan KANG ; Geun Am SONG ; Mong CHO ; Ung Suk YANG
The Korean Journal of Gastroenterology 2003;42(3):220-225
BACKGROUND/AIMS: Serum HBV DNA levels are correlated with hepatic histologic activity in chronic HBV infection based on HBeAg. Liver injury may persist, even though HBV DNA are not detected by hybridization assay. This study was to investigate whether serum HBV DNA levels determined by more sensitive quantitative method are correlated with histologic activities in chronic HBV infections. METHODS: This study included 66 chronic HBV infected patients. HBV DNA level was quantified by Cobas Amplicor HBV Monitor(TM). RESULTS: Serum HBV DNA levels in HBeAg-positive patients were significantly higher than HBeAg-negative patients. In HBeAg-positive patients, serum HBV DNA levels showed a significant negative correlation with portal-periportal activity and fibrosis (r=-0.451, -0.446 respectively). AST levels were correlated with lobular, portal-periportal activity and fibrosis (r=0.432, 0.365, 0.301 respectively), whereas ALT levels were related to lobular activity (r=0.294). Elevated AST levels predicted lobular activity, portal-periportal activity, and fibrosis with moderate to severe degree (OR 1.733, 95% CI 1.083-2.775; OR 1.518, 95% 1.028-2.243, p=0.336; OR 17.897, 95% CI 1.517-211.208, p=0.022, respectively). CONCLUSIONS: In HBeAg-positive patients, serum HBV DNA level correlates inversely with histologic activity. On the other hands AST level correlates with histologic activity and the stage of moderate or severe degree.
Adolescent
;
Adult
;
Child
;
Child, Preschool
;
DNA, Viral/*blood
;
Female
;
Hepatitis B e Antigens/analysis
;
Hepatitis B virus/genetics/*isolation & purification
;
Hepatitis B, Chronic/pathology/*virology
;
Humans
;
Liver/*pathology
;
Male
;
Middle Aged
8.Inflammatory Myofibroblastic Tumor of Extremities.
Chang Bae KONG ; Jeong Dong LEE ; Jung Uk LEE ; Won Seok SONG ; Wan Hyeong CHO ; Jae Soo KOH ; Dae Geun JEON
The Journal of the Korean Bone and Joint Tumor Society 2013;19(1):14-19
PURPOSE: We analyzed the oncologic characteristics and outcome of patients with inflammatory myofibroblastic tumor of extremities. MATERIALS AND METHODS: Among the soft tissue tumor patients who were treated between 1999 and 2012, 5 patients who were pathologically confirmed as the inflammatory myofibroblastic tumor of extremities were analyzed retrospectively. RESULTS: There were 1 man and 4 women with mean age of 44 years (37-55 years). The average follow up was 34.6 months (8-87 months). All patients underwent surgical treatment. Only 1 patient had wide resection margin and remaining 4 had marginal (3) or intralesional (1) resection margin. All of 4 patients without wide resection margin developed local recurrence at 10.3 months (8-19 months). Malignant transformation to fibrosarcoma was occurred in 2 patients who developed local recurrence, and 1 patient developed multiple metastases to lung, liver and lymph nodes and expired at 37 months. Three of 5 patients had tumor location abutted to or invasion to major arteries and 1 patient had tumor invading sciatic nerve. CONCLUSION: It is observed that inflammatory myofibroblastic tumor of extremities is usually located near the major neurovascular structure. Wide resection should be considered as the initial surgical treatment because this tumor showed a high local recurrence rate and possibility of malignant transformation.
Arteries
;
Extremities
;
Female
;
Fibrosarcoma
;
Follow-Up Studies
;
Humans
;
Liver
;
Lung
;
Lymph Nodes
;
Myofibroblasts
;
Neoplasm Metastasis
;
Recurrence
9.Hemangiopericytoma On Buccal Mucosa.
Dae Kyung SUNG ; Jong Cheol JEONG ; Ho Sung KIM ; Jae Uk CHOI ; Gye Hyeok LEE ; Geun Shin RYU
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2000;26(3):301-304
Hemangiopericytoma is uncommon vascular neoplasm that arises from pericytes arround the capillary walls. It was first described as a distinct vascular neoplasm by Stout and Murray in 1942 The anatomic distribution is widespread throughout the body, with approximately one third occur in the head and neck. No sex predilection has been found. Although middle age appears to be the most prevalent time of onset, this neoplasm has been found in all age groups. The differentiation between benign and malignant hemangiopericytoma can be difficult. Although the majority of these tumors are benign, there are malignant variants that can metastasize. Metastasis of seemingly benign tumors may appear year of decade later, so long term close follow-up is needed The treatment of choice is complete surgical excision of the tumor. Despite their vascular origin, these tumors are relatively radioresistant. Radiation therapy is reserved for inoperable metastases or treatment of postoperative surgical fields. Here we present a case of hemangiopericytoma occuring on the Lt. buccal mucosa.
Capillaries
;
Follow-Up Studies
;
Head
;
Hemangiopericytoma*
;
Humans
;
Middle Aged
;
Mouth Mucosa*
;
Neck
;
Neoplasm Metastasis
;
Pericytes
;
Vascular Neoplasms
10.Collateral Vessels in Moyamoya Disease: Comparison of MR and MRA with Conventional Angiography.
Joo Eun SHIM ; Dae Young YOON ; Jeong Geun YI ; Ho Chul KIM ; Chul Sun CHOI ; Sang Hoon BAE
Journal of the Korean Radiological Society 1998;38(1):9-13
PURPOSE: To determine the value of magnetic resonance imaging(MR) and magnetic resonance angiography(MRA) inassessing collateral vessels of moyamoya disease. MATERIALS AND METHODS: Twenty-four patients with moyamoyadisease who underwent MR, 3D TOF MRA, and conventional angiography participated in this study. Two radiologistsworking independently and with no knowledge of the angiographic findings, interpreted the MR and MRA images. Todetermine the presence of parenchymal and leptomeningeal collaterals(48 hemispheres) and transdural collaterals(38hemispheres in 19 patients were depicted by angiography of the external carotid), the findings were compared withthose of angiography. RESULTS: Parenchymal, leptomeningeal, and transdural collaterals were depicted byconventional angiography in 34(71%), 32(67%), and 11(29%) hemispheres respectively. The sensitivity andspecificity of MR/MRA for collateral vessels were 79.1/ 88.1% for parenchymal collaterals, 72.1/ 88.1% forleptomeningeal collaterals, and 0.1/18.1% for transdural collaterals, respectively. Respective sensitivity andspecificity of MR/MRA were 88.94/94.1% for leptomeningeal collaterals, and 18.93/55.1% for transdural collaterals,when the prominent posterior cerebral and external carotid artery were regarded as secondary signs ofleptomeningeal and transdural collateral vessels. CONCLUSION: In moyamoya disease, MR and MRA are useful imagingmodalities for the assessment of collateral vessels. The prominent posterior cerebral artery and external carotidartery can be useful secondary signs of leptomeningeal and transdural collateral vessels.
Angiography*
;
Carotid Artery, External
;
Cerebral Angiography
;
Humans
;
Moyamoya Disease*
;
Posterior Cerebral Artery