1.Expression of Cell Adhesion Molecules -CD44H and CD44v6- in Colorectal Carcinoma.
Dae Cheol KIM ; Seo Hee RHA ; Jin Sook JEONG ; Sook Hee HONG
Korean Journal of Pathology 1998;32(9):655-662
During tumor progression, a subset of cells acquires metastatic properties, presumably through a series of genetic alterations. As the result, cells detach from the primary tumor, penetrate the basement membrane and invade the adjacent structures including lymph and blood vessels. Loss of adhesive functions and gain of new adhesive functions are thought to play a crucial role in this metastatic cascade. Since tumor metastasis is the principle cause of death for cancer patients including colon cancer, there is a consensus that a search for tools that allow effective assessment of the metastatic potential of tumors is a prime goal for cancer research. An immunohistochemical study of cell adhesion molecules, CD44H and its variant CD44v6, was done to evaluate their relationship with known prognostic factors related to the progression and metastasis of colorectal carcinoma in 94 cases of colorectal carcinoma tissues. The results were as follows. The CD44H expression was detected in 90 (95.7%) and CD44v6 in 53 (56.4%) out of 94 cases of colorectal carcinoma, and the CD44H was overexpressed in tumor tissue more than in normal mucosa in 62% of the cases. The expression rates of both protein were not significantly correlated with age and sex of the patients, invasion depth, lymph node metastasis, tumor differentiation, and tumor site. The coexpression of CD44H and CD44v6 in tumor was significant (p<0.05). The above results suggest that overexpression of CD44H and loss of function to control the alternative splicing of CD44 mRNA resulting in CD44v6 expression and alteration of adhesive function are closely associated with tumorigenesis of the colorectum.
Adhesives
;
Alternative Splicing
;
Basement Membrane
;
Blood Vessels
;
Carcinogenesis
;
Cause of Death
;
Cell Adhesion Molecules*
;
Cell Adhesion*
;
Colonic Neoplasms
;
Colorectal Neoplasms*
;
Consensus
;
Humans
;
Lymph Nodes
;
Mucous Membrane
;
Neoplasm Metastasis
;
Prognosis
;
RNA, Messenger
2.Adenomyoepithelioma of the Breast.
Sang Yong LEE ; Hea Kyoung HUR ; Dae Cheol KIM ; Seo Hee RHA ; Sook Hee HONG
Korean Journal of Pathology 1997;31(1):83-86
Adenomyoepithelioma is a rare benign tumor which occurs mainly in the skin, salivary gland and very rarely in the breast. Histologically this tumor demonstrates biphasic differentiation of luminal epithelial cells and myoepithelial cells. We report a case of adenomyoepithelioma occuring in the outer lower quadrant of the right breast of a 56-year-old female, confirmed histologically with an aid of immunohistochemistry. This is the first documented report in Korean literature.
Adenomyoepithelioma*
;
Breast*
;
Epithelial Cells
;
Female
;
Humans
;
Immunohistochemistry
;
Middle Aged
;
Phenobarbital
;
Salivary Glands
;
Skin
3.Malignant Rhabdoid Tumor of the Kidney in an Adult: A case report.
Sang Yong LEE ; Dae Cheol KIM ; Seo Hee RHA ; Sook Hee HONG
Korean Journal of Pathology 1996;30(6):539-543
Malignant rhabdoid tumor is a distinct renal tumor in pediatric age group and extremely rare in adults. It was originally described as a rhabdomyosarcomatoid variant of Wilms' tumor. But subsequent studies failed to confirm myogenous differentiation, so the rhabdoid tumor is now considered to be a distinct and unique disease type of highly malignant renal tumor, histogenetically unrelated to Wilms' tumor. However the histogenesis have not been clearly defined until now. We report a case of malignant rhabdoid tumor of the kidney in a 34-year-old man who represented with a left abdominal mass. Grossly, a large mass occupying most of the left kidney except for a part of upper pole was invading beyond renal capsule and the perirenal soft tissue. It measured 18x14 cm in dimension and was soft, lobulated and yellowish gray with large areas of hemorrhage and necroses. Microscopically, the tumor mass was composed of sheets of round or polygonal neoplastic cells growing in a solid pattern. These tumor cells were medium to large in size with ample cytoplasm containing recognizable eosinophilic inclusion and had an eccentrically located, large nucleus with one or a few prominent nucleoli. Mitotic figures were frequently observed. Ultrastructurally, the tumor cells contained whorled filamentous inclusions corresponding to vimentin, epithelial membrane antigen and cytokeratin in immunostaining.
Adult
;
Male
;
Female
;
Humans
4.Two Cases of Allergic Reactions to Mesna which Imitate Malar Rash.
Jeong Cheol SEO ; Sang Cheol BAE ; Seung Cheol SHIM ; Tae Hwan KIM ; Jae Bum JUN ; Sung Soo JUNG ; In Hong LEE ; Dae Hyun YOO ; Seong Yoon KIM
The Journal of the Korean Rheumatism Association 2000;7(2):196-199
Hemorrhagic cystitis is potentially life-threatening sequellae of chemotherapy using oxazaphosphorine alkylating agents (cyclophosphamide and ifosfamide). Mesna contains a sulfhydryl group that is believed to bind acrolein within the urinary collecting system and reduce the hemorrhagic cystitis without affecting the chemotherapeutic potential. To date, about thirty cases of hypersensitivity or allergic reactions of the delayed and urticarial type associated with mesna have been reported. We reported two patients with systemic lupus erythematosus who developed facial rash and flushing associated with mesna which imitate malar rash.
Acrolein
;
Alkylating Agents
;
Cyclophosphamide
;
Cystitis
;
Drug Therapy
;
Exanthema*
;
Flushing
;
Humans
;
Hypersensitivity*
;
Lupus Erythematosus, Systemic
;
Mesna*
5.Cerebral Arterial Embolism Treated by Intra-Arterial Infusion of Urokinase Which Was Occurred during Percutaneous Balloon Mitral Valvuloplasty.
Jae Joong KIM ; Seung Jung PARK ; Seong Wook PARK ; In Whan SEONG ; Jong Koo LEE ; Youn Mee HWANG ; Dae Cheol SEO
Korean Circulation Journal 1991;21(1):146-150
Cerebral arterial embolism which resulted in total occlusion of right proximal middle cerebral artery was occured in 33 years old female patients with severe mitral stenosis and atrial fibrillation during percutaneous mitral balloon valvuloplasty(PMV). The occluded artery could be detected by transfemoral carotid angiography and recanalized immediately by intra-arterial infusion of urokinase. There were no cerebral hemorrhage by CT scan after intra-arterial urokinase infusion and the patients discharged without any neurologic sequale 7 days after thrombolysis. We report a case of successful recanalization with intraarterial infusion of urokinase in patient with cerebral arterial embolism occurred during PMV.
Adult
;
Angiography
;
Arteries
;
Atrial Fibrillation
;
Cerebral Hemorrhage
;
Embolism*
;
Female
;
Humans
;
Infusions, Intra-Arterial*
;
Intracranial Embolism
;
Middle Cerebral Artery
;
Mitral Valve Stenosis
;
Tomography, X-Ray Computed
;
Urokinase-Type Plasminogen Activator*
6.A Case of Isolated ACTH Deficiency Accompanied by hyperprolactinemia.
Young Seung KIM ; Gwang Il KIM ; Dae Su KIM ; Jeon Ok AN ; Sang Jeong YOON ; Hee Cheol JANG ; Kang Seo PARK
Journal of Korean Society of Endocrinology 1997;12(3):462-467
Isolated ACTH deficiency is a uncommon disorder causing secondary adrenocortical insufficiency. Less than 200 cases have been reported in the world. The major clinical manifestations are hypoglycemia, weight loss, hypotension, anemia, weakness, nausea, inability to excrete water load, and hyponatremia. A 56-year-old male was admitted because of weakness, fatigue, nausea and vomiting. He was pallor and not associated with hyperpigmentation. The basal plasma ACTH and cortisol levels were 8.30 pg/ml and 0.6 ug/dl. The serum cortisol did not response to rapid ACTH stimulation test. On combined pituitary stimulation test, the cortisol did not response to insulin-induced hypoglycemia. Other anterior pituitary hormones showed normal responses except elevated prolactin level. Six months after glucocorticoid replacement therapy, the elevated basal prolactin level returned to normal. Brain MRI did not show any anatomic abnormalities of the sellar and suprasella area. We report a case of isolated ACTH deficiency accompanied by hyperprolactineia, which respond to glucocorticoid replacement therapy.
Adrenal Insufficiency
;
Adrenocorticotropic Hormone*
;
Anemia
;
Brain
;
Fatigue
;
Humans
;
Hydrocortisone
;
Hyperpigmentation
;
Hyperprolactinemia*
;
Hypoglycemia
;
Hyponatremia
;
Hypotension
;
Magnetic Resonance Imaging
;
Male
;
Middle Aged
;
Nausea
;
Pallor
;
Pituitary Hormones, Anterior
;
Plasma
;
Prolactin
;
Vomiting
;
Water
;
Weight Loss
7.Assessment Tools for Psychological Trauma in Children and Adolescent after a Disaster.
Cheol Soon LEE ; Ji Yeong SEO ; Dae Ho KIM ; Soo Young BHANG
Journal of Korean Neuropsychiatric Association 2015;54(3):269-275
Psychological trauma that can influence development of children and adolescents is common. Evaluation of the trauma is important for treatment and predicting prognosis for children and adolescents. There are many ways to evaluate the effect of psychological trauma, but few articles reviewing assessment tools used in Korea have been reported. Therefore we reviewed various checklists, structure and semi-structure interviews for choosing well and useful usage of these resources in the future. We would suggest usage of the Korean Version of Impact of Event Scale-Revised and Korean Version of the Children's Response to Traumatic Events Scale-Revised as a self-report. Korean Version of Clinician Administered posttraumatic stress disorder scale for Children and Adolescents will also be useful for interview of trauma in Korean children and adolescents. Other various tools that have been used in foreign countries reflecting Korean culture and society will need to be standardized.
Adolescent*
;
Checklist
;
Child*
;
Disasters*
;
Humans
;
Korea
;
Prognosis
;
Stress Disorders, Post-Traumatic
8.Role of Endothelium -Derived Relaxing Factor in the Pathogenesis of Coronary Artery Spasm and Its Relationship with Ethanol.
Jung Don SEO ; Jae Kwan SONG ; Cheol Ho KIM ; Dae Won SOHN ; Byung Hee OH ; Myoung Mook LEE ; Young Bae PARK ; Yun Shick CHOI ; Young Woo LEE
Korean Circulation Journal 1992;22(5):768-783
Isometric tension recording was performed in the transverse strips of porcine coronary arteries and rabbit aorta to observe the effects of the endothelium and endothelium-derived relaxing factor(EDRF) on vasomotor tone and to test the hypothesis that alcohol may have the deleterious effect on endothelium-dependent vasorelaxation. Tension-development by vasoconstrictor was markedly attenuated in the endothelium-intact strips compared to the endothelium denuded strips. Administration of hemoglobin(10-5M) to inhibit the action of EDRF increased tension selectively in the endothelium-infarct strips, which is suggestive of basal EDRF secretion. Nitro L-arginine(10-5M). an analogue of L-arginine(10-4M) partially reversed the inhibitory effect of nitro L-arginine. Ethyl alchol inhibited bradykinin-induced endothelium-dependent vasorelaxation of porcine coronary artery in dose dependent manner. These data suggest that the protective effect of vascular endothelium to the action of vasoconstirctor can be explained by exercise of basal EDRF release and damaged endothelium would be a great risk of induction of vasospasm. Also we believe that there is a relationship of competive inhibition between L-arginine. a precursor of EDRF, and its analogues on the action of EDRF and alcohol intake would be hazardous to the patients with coronary artey disease because its inhibitory action on endothelium-dependent vasorelaxation may evoke myocardial ischemia.
Aorta
;
Arginine
;
Coronary Vasospasm
;
Coronary Vessels*
;
Endothelium*
;
Endothelium, Vascular
;
Ethanol*
;
Humans
;
Myocardial Ischemia
;
Spasm*
;
Vasodilation
9.Ictal Cerebral Perfusion Patterns in Partial Epilepsy: SPECT Subtraction.
Hyang Woon LEE ; Seung Bong HONG ; Woo Suk TAE ; Sang Eun KIM ; Dae Won SEO ; Seung Cheol JEONG ; Ji Young YI ; Seung Chyul HONG
Korean Journal of Nuclear Medicine 2000;34(3):169-182
PURPOSE: To investigate the various ictal perfusion patterns and find the relationships between clinical factors and different perfusion patterns. MATERIALS AND METHODS: lnterictal and ictal SPECT and SPECT subtraction were performed in 61 patients with partial epilepsy. Bath positive images showing ictal hypoperfusion and negative images revealing ictal hypoperfusion were obtained by SPECT subtraction. The ictal perfusion patterns of subtracted SPECT were classified into focal hypoperfusion, hypoperfusion-plus, combined hypoperfusion-hypoperfusion, and focal hypoperfusion only. RESULTS: The concordance rates with epileptic focus were 91.8% in combined analysis of ictal hypoperfusion and hypoperfusion images of subtracted SPECT, 85.2% in hypoperfusion images only of subtracted SPECT, and 68.9% in conventional ictal SPECT analysis. Ictal hypoperfusion occurred less frequently in temporal lobe epilepsy (TLE) than extratemporal lobe epilepsy. Mesial temporal hypoperfusion alone was seen only in mesial TLE while lateral temporal hypoperfusion alone was observed only in neocortical TLE. Hippocampal sclerosis had much lower incidence of ictal hypoperfusion than any other pathology. Some patients showed ictal hypoperfusion at epileptic focus with ictal hypoperfusion in the neighboring brain regions where ictal discharges propagated. CONCLUSION: Hypoperfusion as well as hypoperfusion in ictal SPECT should be considered for localizing epileptic focus. Although the mechanisrn of ictal hypopertusion could be an intra-ictal early exhaustion of seizure focus or a steal phenomenon by the propagation of ictal discharges to adjacent brain areas, further study is needed to elucidate it.
Baths
;
Brain
;
Epilepsies, Partial*
;
Epilepsy
;
Epilepsy, Temporal Lobe
;
Humans
;
Incidence
;
Pathology
;
Perfusion*
;
Sclerosis
;
Seizures
;
Tomography, Emission-Computed, Single-Photon*
10.Optimal Number of Blood Cultures and Volume of Blood Needed to Detect Bacteremia in Children.
Jong Jae KIM ; Cheol Am KIM ; Sang Ho BAIK ; Eui Tak OH ; Hong Ja KANG ; Kil Seo KIM
Journal of the Korean Pediatric Society 1998;41(7):917-922
PURPOSE: We compared pathogen recovery rates by obtaining two blood cultures instead of one blood culture containing 1ml and collecting a larger volume, 1 to 3ml. METHODS: Total of 750 blood specimens from 250 patients with fever, a temperature higher than 39degrees C and suspected bacteremia were obtained. Each patient had two samples of blood, A (1ml) and B (4ml), obtained at 30-minute interval from separate sites of extremities and B was divided into B1 (1ml) and B2 (3ml). Each sample was inoculated into aerobic culture media. Patients were excluded if two samples of blood were not obtained or if the isolate represented a contaminant. RESULTS: A pathogen was isolated in 19 (7.6%) of 250 patients and 37 (4.9%) of 750 specimens. In 7 patients, the pathogen was isolated with all the culture methods and in 12 patients, one or more of the cultures yielded no growth. The pathogen recovery rates were 53% (10/19) in A and B1, 89% (17/19) in B2 and 68% (13/19) in A+B1. No difference was detected between A or B1 and A+B1 (P>0.05) and the pathogen recovery rate for B2 was significantly greater than that for A or B1 (P<0.05), but no significant differences were found in pathogen recovery when B2 was compared with A+B1. CONCLUSION: Increasing volume of blood from 1 to 3ml inoculated into blood culture bottles improves detection of bacteremia in pediatric patients and spares patients the cost and pain of an additional venipuncture.
Bacteremia*
;
Child*
;
Culture Media
;
Extremities
;
Fever
;
Humans
;
Phlebotomy