The transient receptor potential( TRP) subfamilies be-long to the non-selective cation channels located at cell mem-branes. Calcium across the plasma membrane into the cell via most TRP channels may result in localized Ca2+ signals that con-tribute to cell proliferation, migration and metastasis. In recent years, many studies have focused on the role of TRP in cancer. This review intends to gather the latest progress concerning TRP channels on proliferation and migration of cancer.