No abstract available.
Dacarbazine*

No abstract available.
Dacarbazine*

No abstract available.
Dacarbazine* ; Gabexate*

Various complications related to anterior lumbar interbody fusion (ALIF) have been reported in the literature. However, disseminated intravascular coagulation (DIC) after venous injury during ALIF has not been previously reported. We describe a rare case of DIC after ALIF.
Dacarbazine ; Disseminated Intravascular Coagulation

No abstract available.
Dacarbazine* ; Disseminated Intravascular Coagulation

BACKGROUND: This study was performed to analyze the appropriateness and the efficacy of fresh frozen plasma (FFP) transfusions for the treatment of coagulopathy. METHODS: Three hundred and eleven patients with FFP transfusion histories were evaluated on the state of coagulopathy and the reasons for transfusion. The reasons were classified according to the recommendations by the British Committee for Standards in Haematology (BCSH) for evaluation of transfusion appropriateness. The efficacy of transfusions was evaluated in 144 patients with coagulopathy by means of delta PT (%) and delta aPTT (sec). Corrected delta PT (c delta PT) and corrected delta aPTT (c delta aPTT) were defined as delta PT and delta aPTT divided by the transfusion amount, and these were compared among the disease groups. RESULTS: Forty-two patients (30.5%) were definitely indicated, and 53 patients (17.0%) were conditionally indicated. One hundred and eighty-four patients (59.2%) were transfused with no justification for the transfusions. Of the improved cases, 27.8% of the patients scored at more than 10% in the PT (%) category. In 28.1% of the patients, there were more than 10 sec in aPTT (sec). There was a significant correlation between the volume of the transfusion (mL/kg) and the delta PT and delta aPTT (r=0.2932, P=0.0004; r=0.2379, P=0.0047; respectively). The c delta PT had an inverse correlation to the elapsed time from transfusion to the coagulation assay (r=-0.1815, P=0.0301). The c delta PT and the c delta aPTT were significantly lower in patients with liver disease than those with DIC (P=0.0009, P=0.0084; respectively). CONCLUSIONS: We found that FFP was transfused more inappropriately than should have been. The transfusion volume was the most significant factor for the efficacy of FFP transfusions. FFP transfusions were less efficient in the patients with liver disease.
Blood Transfusion ; Dacarbazine ; Humans ; Liver Diseases ; Plasma*

The syndrome of diffuse intravascular coagulation or DIC was related with high perinatal mortality & morbidity. One of the most common cause of clinically significant DIC is placental abruption Usually, DIC complicates this obstetrical accident in approximately 30% of cases. The majority of placental abruption occured late pregnancy. But, recently we have experienced a case of DIC in a patient with placental abruption in 16 weeks of gestationl age and reviewed it briefly
Abruptio Placentae* ; Dacarbazine ; Female ; Gestational Age* ; Humans ; Perinatal Mortality ; Pregnancy

The syndrome of diffuse intravascular coagulation or DIC was related with high perinatal mortality & morbidity. One of the most common cause of clinically significant DIC is placental abruption Usually, DIC complicates this obstetrical accident in approximately 30% of cases. The majority of placental abruption occured late pregnancy. But, recently we have experienced a case of DIC in a patient with placental abruption in 16 weeks of gestationl age and reviewed it briefly
Abruptio Placentae* ; Dacarbazine ; Female ; Gestational Age* ; Humans ; Perinatal Mortality ; Pregnancy

Malignant gliomas, including glioblastomas, anaplastic astrocytomas and anaplastic oligodendrogliomas, are the most common primary neoplasm of the human nervous system. Although the results of radiotherapy and chemotherapy such as temozolomide have improved the prognosis of patient with high grade gliomas, generally the outcomes are still miserable due to the resistance to current therapies. Therefore, recent trials and researches have focused on overcoming the resistance to standard chemo- and radiotherapy of malignant gliomas and are demonstrating the outstanding results. In the present review, we provide an overview of current status of the conventional therapies for malignant gliomas and recent advances for overcoming the resistance to the therapies.
Astrocytoma ; Dacarbazine ; Glioblastoma ; Glioma ; Humans ; Nervous System ; Oligodendroglioma ; Prognosis

PURPOSE: To investigate the variation in the chemosensitivity in soft tissue sarcoma (STS), fresh biopsy with sample for culture was tested using the histoculture drug response assay (HDRA)method. MATERIALS AND METHODS: 30 samples of fresh STS were obtained during either biopsy or surgical removal at our hospital between March, 2002 and March, 2004. RESULTS: Drug sensitivity testing by HDRA showed that two drug, Doxorubicin and CDDP, had a significantly higher inhibition rate than BLM, CTX, DTIC, VCR or VP-16 in the thirty STS tested. Doxorubicin showed the highest inhibition rate in the liposarcoma. CDDP shoewd the significant inhibition rate in the synovial sarcoma and malignant fibrous histiocytpma. Depending on the morphological type, round cell sarcoma and pleomorphic sarcoma were more sensitive to Doxorubicin and CDDP than spindle cell sarcoma. In the round cell sarcoma, BLM, CTX, VP-16 and IFS also showed above 30% inhibition rate. CONCLUSION: Drug sensitivity testing in STS should be evaluated with clinical outcome in the future and then HDRA will provide useful information for selection of an anticancer agent for STS because of its ease of evaluation and high predictability.
Biopsy ; Dacarbazine ; Doxorubicin ; Etoposide ; Humans* ; Sarcoma* ; Sarcoma, Synovial