1.Efficacy of catheter-based renal denervation in mongrel neurogenic hypertensive dogs.
Cheng-zhi LU ; Jia LIU ; Da-vng XIA ; Xiang-dong ZHAO ; Xin CHEN ; Xiang YU ; Jian-qiang XU ; Jing ZHANG ; Li PAN ; Shao-ying LIU ; Li WANG
Chinese Journal of Cardiology 2012;40(1):14-17
OBJECTIVEHypertension is the most common risk factor for cardiovascular diseases and stroke. Renal sympathetic hyperactivity is associated with hypertension. The aim of this study was to explore the efficacy of renal denervation for hypertension.
METHODSEighteen mongrel neurogenic hypertensive dogs were divided into intervention [mean arterial pressure: (150.6 ± 18.8) mm Hg (1 mm Hg = 0.133 kPa) plus renal sympathetic denervation by percutaneous catheter-based radiofrequency, n = 10] and control [mean arterial pressure (147.4 ± 13.2) mm Hg, n = 8] group. Mean arterial pressure before and at 2, 4, 6 and 10 weeks after procedure was invasively measured. Renin activity (PRA), angiotensin II (AngII), aldosterone (Ald), and creatinine (Cr) were detected at 2, 6 and 10 weeks after procedure.
RESULTSMean arterial pressure remained unchanged in control group. In intervention group, mean arterial pressure (MAP) decreased to (130.4 ± 14.1) mm Hg, (136.2 ± 17.1) mm Hg, (128.7 ± 14.7) mm Hg and (126.1 ± 12.7) mm Hg respectively at 2, 4, 6, and 10 weeks after procedure. Meanwhile, the level of PRA, AngII, Ald significantly reduced post procedure compared with pre-procedural level (P < 0.05) and the Cr level remained unchanged post procedure (P > 0.05).
CONCLUSIONSympathetic nervous system plays an important role in the progression of hypertension. Catheter-based renal denervation results in substantial and sustained blood-pressure reduction in this model.
Animals ; Catheter Ablation ; methods ; Dogs ; Hypertension ; surgery ; Kidney ; innervation ; surgery ; Sympathectomy ; methods
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