1.Cemented bipolar hemiarthroplasty with a novel cerclage cable technique for unstable intertrochanteric hip fractures in senile patients.
Gui-shan GU ; Gang WANG ; Da-hui SUN ; Da-ming QIN ; Wei ZHANG
Chinese Journal of Traumatology 2008;11(1):13-17
OBJECTIVETo observe the clinical result and assess clinical value of cemented bipolar hemiarthroplasty with a novel cerclage cable technique for treatment of unstable intertrochanteric hip fractures in senile patients.
METHODSForty-eight consecutive patients with unstable intertrochanteric fractures were treated in our hospital from March 2001 to March 2006 (Evans type III in 11 cases, Evans type IV in 25 cases and Evans type V in 22 cases). All the cases were evaluated by Zuckerman functional recovery score (FRS) and operative risk assessment software 1 (ORAS1), which were based on the patients' physical and laboratory examinations preoperatively. Seventeen cases (19 hips) were treated with cemented bipolar hemiarthroplasty. There were 5 male cases (5 hips) and 12 female cases (14 hips, including 2 patients who suffered from additional slight injuries and resulted in contralateral hip fracture and were treated with the same procedure 3 months after the first operation). The average age was 85 years (78-95 years). All the operations were carried out under general anesthesia, through Southern incision and lateral approach by the same orthopaedic surgeon. All prostheses consisted of Link SPII femoral stem and bipolar femoral head. All patients were followed up for more than 30 days.
RESULTSThe operative risks of all the 17 cases (19 hips) were calculated by ORAS1 preoperatively. The average preoperative FRS was 81.7 (80.7-82.7). The average predictive value of operative morbidity was 10% (7%-15%). The average predictive value of mortality was 2.97% (2.1%-3.2%). The average operation time was 1.5 hours. The average blood transfusion was 400 ml. There were no operative or anesthetic complications and no deaths within 30 days after operation. Sitting up was permitted 3 to 4 days after operation, and partial weight bearing was permitted 5 to 7 days after operation. Patients were allowed to walk with a walker 10 days after operation. The average FRS was 78.7 at 30 days postoperatively. No patient died during at least one year follow-up.
CONCLUSIONSAlthough the value of the technique of cemented bipolar hemiarthroplasty in the treatment of unstable intertrochanteric hip fracture is not widely recognized, we have consistently achieved satisfactory results with strict preoperative risk assessment, strict indication selection and systematic postoperative rehabilitation.
Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip ; methods ; Bone Cements ; Female ; Hip Fractures ; surgery ; Humans ; Male ; Treatment Outcome
2.The anatomic study and clinical observation of the neurectomy of the nerve to the medial gastrocnemius muscle for calf reduction.
Da-Lie LIU ; X-Ijun LI ; Lei SHAN ; Qin LI ; Ji-Long YUAN ; Qiang YUAN
Chinese Journal of Plastic Surgery 2007;23(2):125-127
OBJECTIVETo introduce a method to reduce the volume of medial gastrocnemius for calf reduction.
METHODSTibial nerve and nerve branches were dissected and explored at popliteal region for morphometry in 20 cadaver-legs. The length, width and the origination position of the nerve to the medial gastrocnemius were measured and recorded. During surgery, the nerve to the medial gastrocnemius muscle were explored and cut off. The circumference and the shape of the leg were measured and recorded.
RESULTSThe nerve innervating the medial gastrocnemius originates from the tibial nerve which lies in the fat tissue of popliteal space. In 8 cases (40%) there is only 1 branch to the medial gastrocnemius, and in 4 cases (30%) there are 2 branches. In other 4 cases (30%) the medial sural cutaneous nerve originate from the nerve to the medial gastrocnemius. The nerve to the medial gastrocnemius muscle branch off at (- 6.6 +/- 13.7) mm; the width is (2.3 +/- 0.4) mm; the length is (42 +/- 12) mm. Neurectomy of the nerve to the medial gastrocnemius was performed in 16 cases. After operation, the circumference of the leg was reduced (3.5 +/- 1.1) cm averagely and the curve of the medial line of the calf was reduced. There is no obvious swelling in these cases and the patients were able to walk immediately after operation. The function of the leg was not obviously influenced.
CONCLUSIONSNeurectomy of the nerve to the medial gastrocnemius muscle was a safe and effective method for calf reduction.
Adult ; Bariatric Surgery ; Female ; Humans ; Leg ; surgery ; Male ; Muscle Denervation ; Muscle, Skeletal ; innervation ; Sural Nerve ; surgery ; Young Adult
3.Roles of endothelin and its receptors in prostate cancer.
Qing-Bing WANG ; Wu-Shuai QU ; Da-Shan QIN ; Zhi-Ping WANG
National Journal of Andrology 2006;12(5):450-452
Endothelin (ET) is a peptide released by vascular endothelial cells. Except for the potent vasoconstrictor function it plays an important physiological role in tissue differentiation and development, cell proliferation and hormone production. Investigation of the role of ET axis in a variety of tumors such as prostatic, cervical, breast carcinoma has provided evidences of its importance in cancer, recently. Data suggest that multiple functions of the ET axis have associations with mitogenesis, apoptosis inhibition, angiogenesis, and activation of proto-oncogene. The ET axis relates to invasiveness, osteoblast function, and metastatic cancer pain in advanced prostate cancer.
Animals
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Apoptosis
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Endothelins
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physiology
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Humans
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Male
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Mice
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Prostatic Neoplasms
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pathology
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physiopathology
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Receptors, Endothelin
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physiology
4.The effects of a hot water soluble extract (S-03) isolated from Isatis indigotica root on influenza A and B viruses in vitro.
Zi-Feng YANG ; Yu-Tao WANG ; Sheng QIN ; Sui-Shan ZHAO ; Yun-Shi ZHAO ; Qin LIN ; Wen-Da GUAN ; Qun-Di HUANG ; Zi-Yao MO ; Chu-Yuan LI ; Nan-Shan ZHONG
Chinese Journal of Virology 2011;27(3):218-223
This study was to investigate the antiviral effects of a hot water soluble extract S-03 isolated from Isatis indigotica root on different subtypes of influenza A and B viruses in MDCK cell cultures, using plaque reduction, immunofluorescence and hemo-agglutination inhibition (HAD) assays. Chemical analysis of the extract S-03 showed that it contained high proportion of polysaccharides. The antiviral effects in vitro showed that the S-03 had no effect on different influenza viruses if the drug was used before virus adsorption, but S-03 showed obvious activities against influenza viruses if treatment after virus adsorption or direct reaction of drug and virus before virus adsorption. Hemagglutination inhibition assay showed that S-03 inhibited HA activities of different human influenza viruses (inhibition concentration ranged from 3.12 to 25 mg/mL), avain influenza viruses (inhibition concentration ranged from 25 to 50 mg/mL). The antiviral effects of S-03 on different influenza A and B viruses in vitro might be through the inhibition of the HA to prevent infection.
Animals
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Cells, Cultured
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Dogs
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Fluorescent Antibody Technique
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Hemagglutination Inhibition Tests
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Influenza A virus
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drug effects
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Influenza B virus
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drug effects
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Isatis
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chemistry
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Plant Extracts
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pharmacology
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Plant Roots
5.Increase of saliva nitrate and nitrite level in patients with oral candidiasis.
Rui-Tang SHI ; Li-Zheng QIN ; Deng-Sheng XIA ; Da-Jun DENG ; Zhi-Peng FAN ; Zhao-Chen SHAN ; Yan-Ying XU ; Song-Ling WANG
Chinese Journal of Preventive Medicine 2009;43(7):607-610
OBJECTIVETo observe the alterations of saliva nitrate and nitrite level in patients with oral candidiasis.
METHODSParotid saliva and whole saliva were collected from 33 patients and 34 healthy volunteers. Concentrations of nitrate and nitrite in saliva were determined by high-performance liquid chromatography. Follow-up observation was performed on 10 patients after treatment. The data were statistically analyzed with independent-samples t test or paired-samples t test at alpha = 0.05.
RESULTSThere was significant increase of the concentrations and secretion rate of parotid saliva nitrate in patient group as compared with controls: (49.70 +/- 0.50) vs (21.51 +/- 0.60) mg/L (t = 2.692, P = 0.009) and (27.71 +/- 0.50) vs (12.55 +/- 0.60) microg/min (t = 2.554, P = 0.013), respectively. Significantly increased concentrations and secretion rate of nitrate and nitrite [nitrate: (6.46 +/- 0.94) vs (1.11 +/- 0.70) mg/L (t = 3.792, P = 0.000); nitrite: (8.48 +/- 0.58) vs (3.39 +/- 0.53) mg/L (t = 2.888, P = 0.005); nitrate secretion rate: (10.57 +/- 0.91) vs (2.10 +/- 0.74) microg/min (t = 3.464, P= 0.001); nitrite secretion rate: (13.91 +/- 0.55) vs (6.42 +/- 0.58) microg/min (t = 2.397, P = 0.020)] were revealed in whole saliva of patients group. Significantly decreased nitrate and nitrite levels were also observed in patients after treatment, especially the changes of parotid saliva nitrate secretion rate [(37.50 +/- 0.50) vs (14.34 +/- 0.64) microg/min (t = 3.142, P = 0.012)], whole saliva nitrate [(14.29 +/- 1.01) vs (2.59 +/- 1.03) mg/L (t = 3.475, P = 0.007)] and whole saliva nitrate secretion rate [(25.97 +/- 0.93) vs (4.12 +/- 1.00) microg/min (t = 3.922, P = 0.003)].
CONCLUSIONThe present study revealed the significant increase of salivary nitrate and nitrite level in patients with oral candidiasis is considered to be associated with the host defense reaction.
Adult ; Aged ; Candidiasis, Oral ; metabolism ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Nitrates ; metabolism ; Nitrites ; metabolism ; Saliva ; secretion ; Young Adult
6.Free graft two-stage urethroplasty for hypospadias repair.
Zhong-jin YUE ; Ling-jun ZUO ; Jia-ji WANG ; Gan-ping ZHONG ; Jian-ming DUAN ; Zhi-ping WANG ; Da-shan QIN
Chinese Medical Sciences Journal 2005;20(2):119-122
OBJECTIVETo evaluate the effectiveness of free graft transplantation two-stage urethroplasty for hypospadias repair.
METHODSFifty-eight cases with different types of hypospadias including 10 subcoronal, 36 penile shaft, 9 scrotal, and 3 perineal were treated with free full-thickness skin graft or (and) buccal mucosal graft transplantation two-stage urethroplasty. Of 58 cases, 45 were new cases, 13 had history of previous failed surgeries. Operative procedure included two stages: the first stage is to correct penile curvature (chordee), prepare transplanting bed, harvest and prepare full-thickness skin graft, buccal mucosal graft, and perform graft transplantation. The second stage is to complete urethroplasty and glanuloplasty.
RESULTSAfter the first stage operation, 56 of 58 cases (96.6%) were successful with grafts healing well, another 2 foreskin grafts got gangrened. After the second stage operation on 56 cases, 5 cases failed with newly formed urethras opened due to infection, 8 cases had fistulas, 43 (76.8%) cases healed well.
CONCLUSIONSFree graft transplantation two-stage urethroplasty for hypospadias repair is a kind of effective treatment with broad indication, comparatively high success rate, less complications and good cosmatic results, indicative of various types of hypospadias repair.
Adolescent ; Adult ; Child ; Child, Preschool ; Humans ; Hypospadias ; surgery ; Male ; Mouth Mucosa ; transplantation ; Penis ; abnormalities ; surgery ; Retrospective Studies ; Scrotum ; abnormalities ; surgery ; Skin Transplantation ; Treatment Outcome ; Urethra ; surgery ; Urologic Surgical Procedures, Male ; methods
7.Association of obesity and brachial-ankle pulse wave velocity among type 2 diabetes patients
Zhe HUANG ; Bei-bei XU ; Xiao-wen WANG ; Shan-shan YAO ; Gui-ying CAO ; Man LI ; Ya-ying CAO ; Yao-hua TIAN ; Yao WU ; Shao-ping HUANG ; Xiao-fen LIU ; Xue-ying QIN ; Xun TANG ; Jin LI ; Tao WU ; Da-fang CHEN ; Yong-hua HU
Chinese Journal of Disease Control & Prevention 2019;23(9):1086-1091
Objective The aim of this study was to investigate associations of overall obesity (OO) and abdominal obesity (AO) with brachial-ankle pulse wave velocity (baPWV) among type 2 diabetes(T2DM) patients. Methods A community-based study for T2DM patients was conducted in rural communities in Beijing.Every patient completed a questionnaire to collect demography, lifestyle and diseases history, and underwent physical examinations, baPWV assessments and blood biochemical tests. Multivariate linear regression was used to assess the relationship between obesity index and baPWV. Abnormal baPWV was defined as patients with baPWV≥1,700 cm/s. Logistic regression model was performed to explore the risk of abnormal baPWV after adjusting for poetential confounders step by step. Results A total of 2 048 T2DM patients were recruited. The average age was (59.2±8.3) years and total prevalence of abnormal baPWV was 49.7%. After multivariable adjustment, linear regression showed that there was a negative correlation between body mass index(BMI) and baPWV and a positive correlation between waist-to-hip ratio (WHR) and baPWV. Compared to normal weight group, those with BMI≥28 kg/m2 had lower risk of abnormal baPWV (OR=0.59, 95% CI: 0.44-0.78,P<0.001), but there was an increased risk of 46% among patients with obesity in WHR (OR=1.46, 95% CI:1.07-2.00,P=0.018). Compared to those without OO and AO, patients without OO but with AO had a 1.67-fold increasesd risk of abnormal baPWV (OR=1.67, 95% CI: 1.19-2.35,P=0.003). Conclusions Abdominal obesity is related with arterial stiffnening among T2DM patients, and it is critical to evaluate arterial stiffness of T2DM patients with abdmonal obesity and normal BMI in order to reduce future risk of cardiovascular diseases.
8.Research Progress of Shengjiangsan in Treating Systemic Inflammatory Response Syndrome
Yun-pu QIN ; Ming-da BI ; Shan-shan ZHANG ; Yu HAN ; Ji-hong FENG
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(23):187-192
Shengjiangsan was recorded in a medical book
9.Immune response in Balb/c mice induced by recombinant spike protein of severe acute respiratory syndrome coronavirus.
Li QIN ; Shao-ting WU ; Xi-ming WANG ; Shi-shan YUAN ; Da-na HUANG ; Ming-jun LEI ; Hui-rong PAN ; Qi-ping LIN ; Shi-tong GAO ; Ren-li ZHANG ; Shen QU
Chinese Medical Journal 2005;118(10):857-860
Animals
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Antibodies, Viral
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blood
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Cytokines
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blood
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Female
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Immunoglobulin G
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blood
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classification
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Membrane Glycoproteins
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immunology
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Mice
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Mice, Inbred BALB C
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Recombinant Proteins
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immunology
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Severe Acute Respiratory Syndrome
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immunology
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Spike Glycoprotein, Coronavirus
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T-Lymphocyte Subsets
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immunology
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Viral Envelope Proteins
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immunology
10.Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study.
Ying WEN ; Li JIANG ; Yuan XU ; Chuan-yun QIAN ; Shu-sheng LI ; Tie-he QIN ; Er-zhen CHEN ; Jian-dong LIN ; Yu-hang AI ; Da-wei WU ; Yu-shan WANG ; Ren-hua SUN ; Zhen-jie HU ; Xiang-yuan CAO ; Fa-chun ZHOU ; Zhen-yang HE ; Li-hua ZHOU ; You-zhong AN ; Yan KANG ; Xiao-chun MA ; Xiang-you YU ; Ming-yan ZHAO ; Xiu-ming XI ; Bin DU ; null
Chinese Medical Journal 2013;126(23):4409-4416
BACKGROUNDAcute kidney injury (AKI) has been recognized as a major healthcare problem affecting millions of patients worldwide. However, epidemiologic data concerning AKI in China are still lacking. The objectives of this study were to characterize AKI defined by RIFLE criteria, assess the association with hospital mortality, and evaluate the impact of AKI in the context of other risk factors.
METHODSThis prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across mainland China. We excluded patients who were admitted for less than 24 hours (n = 1623), younger than 18 years (n = 127), receiving chronic hemodialysis (n = 29), receiving renal transplantation (n = 1) and unknown reasons (n = 28). There were 1255 patients in the final analysis. AKI was diagnosed and classified according to RIFLE criteria.
RESULTSThere were 396 patients (31.6%) who had AKI, with RIFLE maximum class R, I, and F in 126 (10.0%), 91 (7.3%), and 179 (14.3%) patients, respectively. Renal function deteriorated in 206 patients (16.4%). In comparison with non AKI patients, patients in the risk class on ICU admission were more likely to progress to the injury class (odds ratio (OR) 3.564, 95% confidence interval (CI) 1.706 - 7.443, P = 0.001], while patients in the risk class (OR 5.215, 95% CI 2.798-9.719, P < 0.001) and injury class (OR 13.316, 95% CI 7.507-23.622, P < 0.001) had a significantly higher probability of deteriorating into failure class. The adjusted hazard ratios for 90-day mortality were 1.884 for the risk group, 3.401 for the injury group, and 5.306 for the failure group.
CONCLUSIONSThe prevalence of AKI was high among critically ill patients in Chinese ICUs. In comparison with non-AKI patients, patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class F. The RIFLE criteria were robust and correlated well with clinical deterioration and mortality.
Acute Kidney Injury ; epidemiology ; etiology ; pathology ; Adult ; Aged ; China ; epidemiology ; Female ; Humans ; Intensive Care Units ; statistics & numerical data ; Male ; Middle Aged ; Prospective Studies ; Risk Factors