Purpose: Nursing care activities for patient safety are important to prevent accidents. This study aimed to examine the association between nurses’ perception of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing care activities for patient safety. Methods: In this cross-sectional study, data were obtained from online surveys conducted with 201 ward nurses. An independent t-test, one-way ANOVA, Pearson’s correlation coefficient test, and multiple linear regression analysis were performed using IBM SPSS/WIN 21.0. Results: Perceptions of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing activities for patient safety were all correlated with each other. According to the regression model, significant factors influencing nursing care activities for patient safety were medical ward (β=-.28, p=.010), critical thinking disposition (β=.27, p<.001), willingness to report near misses (β=.19, p=.004), perceptions of patient safety culture (β=.19, p=.007), and work experience (β=-.18, p=.016). Conclusion Improving nurses’ perceptions of patient safety culture, promoting the reporting of near misses, and strengthening nurses' critical thinking dispositions can foster patient-safety nursing care activities. Additionally, a tailored patient safety education program that considers nursing work experience may be appropriate for patient-safety nursing care activities.

Purpose: Nursing care activities for patient safety are important to prevent accidents. This study aimed to examine the association between nurses’ perception of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing care activities for patient safety. Methods: In this cross-sectional study, data were obtained from online surveys conducted with 201 ward nurses. An independent t-test, one-way ANOVA, Pearson’s correlation coefficient test, and multiple linear regression analysis were performed using IBM SPSS/WIN 21.0. Results: Perceptions of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing activities for patient safety were all correlated with each other. According to the regression model, significant factors influencing nursing care activities for patient safety were medical ward (β=-.28, p=.010), critical thinking disposition (β=.27, p<.001), willingness to report near misses (β=.19, p=.004), perceptions of patient safety culture (β=.19, p=.007), and work experience (β=-.18, p=.016). Conclusion Improving nurses’ perceptions of patient safety culture, promoting the reporting of near misses, and strengthening nurses' critical thinking dispositions can foster patient-safety nursing care activities. Additionally, a tailored patient safety education program that considers nursing work experience may be appropriate for patient-safety nursing care activities.

Purpose: Nursing care activities for patient safety are important to prevent accidents. This study aimed to examine the association between nurses’ perception of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing care activities for patient safety. Methods: In this cross-sectional study, data were obtained from online surveys conducted with 201 ward nurses. An independent t-test, one-way ANOVA, Pearson’s correlation coefficient test, and multiple linear regression analysis were performed using IBM SPSS/WIN 21.0. Results: Perceptions of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing activities for patient safety were all correlated with each other. According to the regression model, significant factors influencing nursing care activities for patient safety were medical ward (β=-.28, p=.010), critical thinking disposition (β=.27, p<.001), willingness to report near misses (β=.19, p=.004), perceptions of patient safety culture (β=.19, p=.007), and work experience (β=-.18, p=.016). Conclusion Improving nurses’ perceptions of patient safety culture, promoting the reporting of near misses, and strengthening nurses' critical thinking dispositions can foster patient-safety nursing care activities. Additionally, a tailored patient safety education program that considers nursing work experience may be appropriate for patient-safety nursing care activities.

Purpose: Nursing care activities for patient safety are important to prevent accidents. This study aimed to examine the association between nurses’ perception of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing care activities for patient safety. Methods: In this cross-sectional study, data were obtained from online surveys conducted with 201 ward nurses. An independent t-test, one-way ANOVA, Pearson’s correlation coefficient test, and multiple linear regression analysis were performed using IBM SPSS/WIN 21.0. Results: Perceptions of patient safety culture, willingness to report near misses, critical thinking disposition, and nursing activities for patient safety were all correlated with each other. According to the regression model, significant factors influencing nursing care activities for patient safety were medical ward (β=-.28, p=.010), critical thinking disposition (β=.27, p<.001), willingness to report near misses (β=.19, p=.004), perceptions of patient safety culture (β=.19, p=.007), and work experience (β=-.18, p=.016). Conclusion Improving nurses’ perceptions of patient safety culture, promoting the reporting of near misses, and strengthening nurses' critical thinking dispositions can foster patient-safety nursing care activities. Additionally, a tailored patient safety education program that considers nursing work experience may be appropriate for patient-safety nursing care activities.

In pre-surgical evaluation of pediatric epilepsy, the combined use of multiple imaging modalities for precise localization of the epileptogenic focus is a worthwhile endeavor. Advanced neuroimaging by high field Magnetic resonance imaging (MRI), diffusion tensor images, and MR spectroscopy have the potential to identify subtle lesions. 18F-FDG positron emission tomography and single photon emission tomography provide visualization of metabolic alterations of the brain in the ictal and interictal states. These techniques may have localizing value for patients which exhibit normal MRI scans. Functional MRI is helpful for non-invasively identifying areas of eloquent cortex. These advances are improving our ability to noninvasively detect epileptogenic foci which have gone undetected in the past and whose accurate localization is crucial for a favorable outcome following surgical resection.
Brain ; Diffusion ; Epilepsy ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Neuroimaging ; Positron-Emission Tomography

The clustered regularly interspaced short palindromic repeats (CRISPR) system, a rapidly advancing genome editing technology, allows DNA alterations into the genome of organisms. Gene editing using the CRISPR system enables more precise and diverse editing, such as single nucleotide conversion, precise knock-in of target sequences or genes, chromosomal rearrangement, or gene disruption by simple cutting. Moreover, CRISPR systems comprising transcriptional activators/repressors can be used for epigenetic regulation without DNA damage. Stem cell DNA engineering based on gene editing tools has enormous potential to provide clues regarding the pathogenesis of diseases and to study the mechanisms and treatments of incurable diseases. Here, we review the latest trends in stem cell research using various CRISPR/Cas technologies and discuss their future prospects in treating various diseases.

BACKGROUND: This study aimed to evaluate the adhesion of Acanthamoeba trophozoites on cosmetic contact lenses (CLs) with and without CL care multipurpose solution (MPS) treatment. METHODS: Acanthamoeba lugdunensis L3a trophozoites were inoculated onto disks trimmed from CLs: 1-day Acuvue moist, 1-day Acuvue define, Acuvue 2, and Acuvue 2 define. After 18-hour inoculation, the number of adherent trophozoites was counted under phase contrast microscopy. The effects of MPS, Opti-Free Express, soaking CLs for 6 hours, on Acanthamoeba adhesion were analyzed. Scanning electron microscopic examination was performed for assessment of Acanthamoeba attached on the lens surface. RESULTS: Acanthamoeba trophozoites showed greater adhesion to cosmetic CL (P = 0.017 for 1-day CL and P = 0.009 for 2-week CL) although there was no significant difference between the types of cosmetic CL. On all lenses, the number of adherent Acanthamoeba was significantly reduced after treatment with MPS (P < 0.001 for 1-day Acuvue moist, P = 0.046 for 1-day Acuvue define, P < 0.001 for Acuvue 2, and P = 0.015 for Acuvue 2 define), but there was still significant difference between conventional and cosmetic CLs (P = 0.003 for 1-day CL and P < 0.001 for 2-week CL, respectively). More attachment of Acanthamoeba was observed on colored area and the acanthopodia of Acanthamoeba was placed on the rough surface of colored area. CONCLUSION: Acanthamoeba showed a greater affinity for cosmetic CL and mostly attached on colored area. Although MPS that contained myristamidopropyl dimethylamine reduced the adhesion rate, there was a significant difference between conventional and cosmetic CLs.
Acanthamoeba ; Contact Lenses ; Microscopy, Phase-Contrast ; Trophozoites

Respiratory epithelial adenomatoid hamartoma (REAH) in the head and neck is a rare benign lesion containing glandular tissue covered with ciliated respiratory epithelium. In the head and neck, REAH of the nasal cavity, paranasal sinuses, and nasopharynx have been reported in literature. Due to rareness of REAH and insufficient knowledge of its imaging features, the diagnosis can be challenging when we encounter a non-specific cystic mass at an uncommon site in the head or neck. Here, we report the case of a pathologically confirmed REAH showing a cystic mass centered at the buccal space (retromaxillary fat pad) with CT and MRI findings.

Respiratory epithelial adenomatoid hamartoma (REAH) in the head and neck is a rare benign lesion containing glandular tissue covered with ciliated respiratory epithelium. In the head and neck, REAH of the nasal cavity, paranasal sinuses, and nasopharynx have been reported in literature. Due to rareness of REAH and insufficient knowledge of its imaging features, the diagnosis can be challenging when we encounter a non-specific cystic mass at an uncommon site in the head or neck. Here, we report the case of a pathologically confirmed REAH showing a cystic mass centered at the buccal space (retromaxillary fat pad) with CT and MRI findings.

Respiratory epithelial adenomatoid hamartoma (REAH) in the head and neck is a rare benign lesion containing glandular tissue covered with ciliated respiratory epithelium. In the head and neck, REAH of the nasal cavity, paranasal sinuses, and nasopharynx have been reported in literature. Due to rareness of REAH and insufficient knowledge of its imaging features, the diagnosis can be challenging when we encounter a non-specific cystic mass at an uncommon site in the head or neck. Here, we report the case of a pathologically confirmed REAH showing a cystic mass centered at the buccal space (retromaxillary fat pad) with CT and MRI findings.