Objective:To investigate the value of fine liver surgery concept in the treatment of HCC.Methods:Retrospective analysis of 121 cases of HCC with liver resection in our hospital from September 2010 to September 2015,according to the operation method,they were divided into the fine liver resection group and the traditional liver resection group,the two groups of operation conditions,postoperative conditions,complications and follow-up results were compared.Results:The operation time of the fine liver resection group was longer than that of the traditional liver resection group,the amount of blood loss,blood transfusion,blood transfusion rate,hepatic portal occlusion rate,and the length of stay in the fine liver resection group were lower than those in the traditional liver resection group,and the difference was statistic:-.significant (P＜0.05);The ALT and TB in the patients with fine liver resection group postoperative 1 days,3 days and 5 days were lower than those in the traditional liver resection group,and the difference was statistically significant(P＜0.05);The incidence of postoperative complications in the fine liver resection group (7 cases,15.56％) was lower than that in the conventional liver resection group (25 cases,32.89％),and the difference was statistically significant (P＜0.05);The residual rate of resection margins and recurrence rate (4.44％,11.11％) in the fine liver resection group were lower than that of conventional liver resection group (17.11％,48.68％),and the difference was statistically significant (P＜0.05);The survival rate after precise liver resection 1 year and 2 years in the fine liver resection group (92.17％,85.31％) was higher than that of traditional liver resection group(90.58％,72.45％),and the difference was statistically significant (x 2=7.715,P=0.005).Conclusion:The efficacy and safety of fine liver resection in the treatment of HCC was superior to that of conventional liver resection.

Objective To investigate the influence of nursing intervention on hormone treatment compliance of patients with nephrotic syndrome. Methods 130 patients with nephrotic syndrome who received hormone treatment were randomly divided into the experimental group and the control group ac-cording to the time of admission. The control group were treated with conventional nursing, and the ex-perimental group was given whole-process health education besides conventional nursing.Using question-naires, the level of relevant knowledge and medication compliance were compared between the two groups .The results underwent χ2 and t test. Results The treatment compliance was not significant be-fore nursing intervention, while after nursing intervention, the treatment compliance of the experimental group was better than that of the control group. The score of relevant knowledge about nephrotic syn-drome of the experimental group was higher than that of the control group Conclusions Active nurs-ing intervention can improve the health knowledge level of patients and improve the treatment compli-ance of hormone therapy.

Hepatitis C, Chronic ; etiology ; pathology ; therapy ; Humans ; Recurrence

Humans ; Oral Surgical Procedures ; adverse effects ; Postoperative Complications ; etiology ; prevention & control

Objective To study chitosan's improving proliferation effect to the bladder epithelial cells,thus providing experlimental foundation for the treatment of interstitial cystitis.Methods Bladder epithelial cells were harested by the enzymatic digestion of the epithelium exposed by the eversion of reseeted New-Zealand hare's bladder.The cells were cultured in different concentrations(0.3、0.6、1.2、2.4、4.8 g/L)of chitosan group and control group,after 72 h,observing their growth and proliferation with optical microscopy;The effects of chitosan on proliferation of rabbit bladder epithelial cells were studied by NAG assay.EGFR mRNA was measured by PT-PCR.Results The growth of cells in the sample added chitosan is much better than that of in the control group.Chitosan could promote the proliferation of bladder epithelial cells at higher than 0.3 g/L of concentration in a dose dependent way.The optimum concentration to increase proliferation of eonjunctival epithelial cells was 1.2 g/L.The proliferative effect of EGFR mRNA increased with the elevated chitosan concentration after 72 h.Conclusions Chitosan can promote the growth of the bladder epithelial eell,which can provides a valuable evidence for further studies of interstitial cystitis's treatment.This proliferation effect is perhaps related to chitosan's promoting EGFR combinating specificity with EGFR.

Objective: To study the influence of chitosan on proliferation of bladder epithelial cells, so as to discuss its feasibility in treatment of interstitial cystitis. Methods: Bladder epithelial cells were harvested by enzymatic digestion of the epithelium of New-Zealand rabbit bladder. The cells were cultured in different concentrations of chitosan(0.3, 0.6, 1.2, 2.4 and 4.8 g/L) for 72 h; untreated cells served as control. The growth and proliferation of cells were observed under microscope. The effects of chitosan on proliferation of cells were studied by NAG assay and cell counting. Results: Immunohistochemistry staining revealed that the cultured cells were epithelial cells. Chitosan (>0.3 g/L) promoted the growth of epithelial cells, and the promoting effect was significantly when the concentration of chitosan was 1.2 g/L (P<0.01). The promoting effects were decreased when the concentrations of chitosan were 2.4 and 4.8 g/L, but were still higher than that of the control group (P<0.01). Conclusion: Chitosan can promote the growth of the bladder epithelial cell in vitro, which might contribute to the treatment of interstitial cystitis.

Hepatitis B, Chronic ; drug therapy ; Humans ; Interferon-alpha ; therapeutic use ; Nucleotides ; therapeutic use ; Polyethylene Glycols

Humans ; Myocardial Infarction ; physiopathology ; Myocardial Reperfusion Injury

The spindle assembly checkpoint ( SAC) is an important monitoring mechanism to monitor the connection between centromeres and microtubules and to ensure proper chromosome separation in human .Mitotic arrest defective protein(Mad)family,as an important part of SAC,plays a crucial role in the process of mitosis. Mutations or altered expressions of Mad may lead to abnormal separations of chromosomes and play a partial role in tumorigenesis ,poor prognosis and chemotherapy drug resistance .

The process of tumorigenesis,local invasion and distant metastasis will produce a series of molecular changes,these genetic mutation or abnormal expression of molecules play a promoting role in hypercoagulation.At the same time,hypercoagulation also increases the risk of tumor progression.It is important to understand their specific processes and the molecular role,and it can provide theoretical basis for better management of patients,and has significance for developing more effective and security new anti-clotting drugs.