2.One case of benzene induced acute leukemia.
Chang-ming REN ; Wen-da LUO ; Chang-wei FENG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(1):20-20
Acute Disease
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Adult
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Benzene
;
poisoning
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Female
;
Humans
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Leukemia
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chemically induced
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Occupational Exposure
;
adverse effects
4.Effects of estrogen on neuron structure and expression of estrogen receptor in hypotha-lamus
Qing CHANG ; Da-Jun YING ; Chang-Xu SHI
Journal of Third Military Medical University 2001;23(3):318-320
Objective To explore the changes of ER-IR and the ultra structure in the medial preoptic area, arcuate nuclei of early-aged mice treated with estrogen. Methods Immunohistochemistry assay and electron microscopy were used in this study. Results ER-IR in the medical preoptic area and arcuate nuclei were greatly reduced after estrogen was given. The cell nuclei of neurons in these areas migrated towards the side, the nuclear membrane became folded, synapse became richer, and the number of synapse vesicle increased. Conclusion Estrogen can affect the neuron structure and function through the change of estrogen receptor expression in the medial preoptic area and arcuate nuclei of the hypothalamus cardiovascular center.
5. Antioxidant and hepatoprotective effects of Ajuga nipponensis extract by ultrasonic-assisted extraction
Chang-Wei HSIEH ; Wai-Jane HO ; Jen-Chieh TSAI ; Chang-Wei HSIEH ; Chao-Kai CHANG ; Wen-Ching KO ; Guo-Jhou CHEN
Asian Pacific Journal of Tropical Medicine 2016;9(5):420-425
Objective To investigate suitable condition for extraction of the active components from Ajuga nipponensis (A. nipponensis). Methods Orthogonal experimental design was used to determine the optimal extraction parameters for ecdysterones and flavonoids. Finally, the hepatoprotective abilities of A. nipponensis extracts were evaluated by CCl
6.Spindle cell variants of diffuse large B cell lymphoma: report of 2 cases.
Jun-chen WANG ; Da-ren SHI ; Xue-lian FU ; Chang-li LU ; Wan-ping LU
Chinese Journal of Pathology 2005;34(1):55-56
Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Breast
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pathology
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Breast Neoplasms
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drug therapy
;
pathology
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Cyclophosphamide
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therapeutic use
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Diagnosis, Differential
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Doxorubicin
;
therapeutic use
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Female
;
Follow-Up Studies
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Humans
;
Lymphoma, B-Cell
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drug therapy
;
pathology
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Lymphoma, Large B-Cell, Diffuse
;
drug therapy
;
pathology
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Male
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Middle Aged
;
Prednisone
;
therapeutic use
;
Sarcoma
;
pathology
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Spleen
;
pathology
;
Splenic Neoplasms
;
drug therapy
;
pathology
;
Vincristine
;
therapeutic use
7.Studies on chemical constituents from roots of Caragana sinica.
China Journal of Chinese Materia Medica 2008;33(5):517-521
OBJECTIVETo study the chemical constituents in roots of Caragana sinica.
METHODThe constituents were isolated by silica gel column chromatography, and their structures were identified by spectroscopic methods.
RESULTSeven compounds were identified as (+) - stenophyllol B (1), 4-hydroxybenzoic acid (2), odoratin (3), resveratrol (4), cararosinol A (5), leachinol C (6), carasinaurone (7) respectively.
CONCLUSIONCompound 1 was a new compound which was the enantiomer of stenophyllol B. Compounds 2-6 were obtained from the plant for the first time.
Caragana ; chemistry ; Chromatography, Gel ; Drugs, Chinese Herbal ; analysis ; chemistry ; Molecular Structure ; Parabens ; analysis ; chemistry ; Plant Roots ; chemistry ; Stilbenes ; analysis ; chemistry
8.Over-articular external fixator combined with limited internal fixation for the treatment of high-energy Pilon fractures.
Da-Cheng LIU ; Xiao-Ning YANG ; Chang-Zhi HUANG ; Yi-Gong SUN ; Xing-Ming DAI
China Journal of Orthopaedics and Traumatology 2014;27(4):331-334
OBJECTIVETo study clinical effects of the over-articular external fixator combined with limited internal fixation for the treatment of Pilon fractures caused by high energy.
METHODSFrom September 2003 to April 2011, 36 patients with Pilon fractures caused by high energy were treated with the over-articular external fixator combined with limited internal fixator. There were 25 males and 11 females, ranging in age from 16 to 72 years old,with an average of 38 years old. The diagnoses of all patients were determined by conventional X-ray examination or three-dimensional spiral CT examination. The AOFAS scoring criteria was used to evaluate the therapeutic effects. The patients with comminuted fractures were treated with screw or Kirschner wire fixation without uncovering periost so as to enhance stability between fracture end and bone blocks,followed by the fixation with over-articular external fixators.
RESULTSAll the patients were followed up, and the duration ranged from 4 to 27 months, with an average of 13 months. Thirty-two patients got wound healing at the first stage. And the bone union duration ranged from 2 to 6 months, with a mean of 3 months. According to the AOFAS ankle-hindfoot subjective scoring standard, 13 patients got an excellent result, 20 good and 3 fair, with an score of 88.2 +/- 3.6. Twelve patients had infections at pinhole, 5 patients had pinhole pain. One patient had the fixator broken induced by over loading, who was cured after treatment. There were no complications such as nerve or vascular injuries, or osteomyelitis.
CONCLUSIONThe over-articular external fixation combined with limited internal fixation for the treatment of Pilon fractures caused by high energy is an ideal method, which has such advantages as reliable fixation, simple operation, coincidence with principles of biomechanical fixation, and benefit for fracture healing.
Adolescent ; Adult ; Aged ; Ankle Injuries ; diagnostic imaging ; surgery ; Ankle Joint ; diagnostic imaging ; surgery ; External Fixators ; Female ; Fracture Fixation ; Fracture Fixation, Internal ; Humans ; Internal Fixators ; Male ; Middle Aged ; Radiography ; Treatment Outcome ; Young Adult
9.Clinical observation on the relation between the confident degree of the patient with pain in acupuncture and moxibustion with the therapeutic effect.
Chinese Acupuncture & Moxibustion 2006;26(5):355-356
OBJECTIVETo understand preliminary relation between patient's confident degree in acupuncture and moxibustion with the therapeutic effect on pain.
METHODSFifteen cases with pain were investigated. The confident degree for acupuncture and moxibustion and pain degree were evaluated by the patient with visual analogue scale (VAS), and the pain VAS scores before and after acupuncture were recorded as the indexes for assessment of the therapeutic effect.
RESULTSAfter acupuncture treatment, the average pain VAS score was decreased by 3.3 +/- 2.8 (P< 0 . 5). There was no significant correlativity between the patient's confident degree VAS and the pain VAS change rate before and after the treatment (R = 0.62, P = 0.83).
CONCLUSIONThere is no significant correlativity between the confident degree of the patient of pain in acupuncture and moxibustion and clinical therapeutic effect.
Acupuncture Analgesia ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Moxibustion ; Pain ; psychology ; Pain Management ; Pain Measurement
10.Sodium houttuyfonate inhibits virulence related motility of Pseudomonas aeruginosa.
Da-qiang WU ; Wei-feng HUANG ; Qiang-jun DUAN ; Hui-juan CHENG ; Chang-zhong WANG
China Journal of Chinese Materia Medica 2015;40(8):1585-1588
Sodium houttuyfonate (SH) is a derivative of effective component of a Chinese material medica, Houttuynia cordata, which is applied in anti-infection of microorganism. But, the antimicrobial mechanisms of SH still remain unclear. Here, we firstly discovered that SH effectively inhibits the three types of virulence related motility of.Pseudomonas aeruginosa, i.e., swimming, twitching and swarming. The plate assay results showed that the inhibitory action of SH against swimming and twitching in 24 h and swarming in 48 h is dose-dependent; and bacteria nearly lost all of the motile activities under the concentration of 1 x minimum inhibitory concentration (MIC) (512 mg x L(-1) same as azithromycin positive group (1 x MIC, 16 mg x L(-1)). Furthermore, we found that the expression of structural gene flgB and pilG is down-regulated by SH, which implies that inhibitory mechanism of SH against motility of P. aeruginosa may be due to the inhibition of flagella and pili bioformation of P. aeruginosa by SR Therefore, our presented results firstly demonstrate that SH effectively inhibits the motility activities of P. aeruginosa, and suggest that SH could be a promising antipseudomonas agents in clinic.
Alkanes
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pharmacology
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Anti-Bacterial Agents
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pharmacology
;
Bacterial Proteins
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genetics
;
metabolism
;
Biofilms
;
drug effects
;
Drugs, Chinese Herbal
;
pharmacology
;
Fimbriae, Bacterial
;
drug effects
;
genetics
;
metabolism
;
Houttuynia
;
chemistry
;
Pseudomonas aeruginosa
;
cytology
;
drug effects
;
genetics
;
pathogenicity
;
Sulfites
;
pharmacology
;
Virulence
;
drug effects