Ductal carcinoma in situ belongs to the early stage of breast cancer.The treatment of ductal carcinoma in situ is similar with that of the breast cancer.Because of the low mortality rate in patients with ductal carcinoma in situ,there was an excessive treatment in the treatment of ductal carcinoma in situ.So the key to the treatment of ductal carcinoma in situ was to improve the quality of life.The present study shows that the effect of conserving surgery with radiotherapy is same with mastectomy's in the treatment of breast ductal carcinoma in situ.Sentinel lymph node biopsy can also be used to evaluate the patient's axillary status.For patients with ductal carcinoma in situ with breast conserving surgery,radiotherapy and endocrine therapy can reduce the recurrence rate of ipsilateral breast cancer.Radiotherapy and endocrine therapy have also become the standard treatment for ductal carcinoma in situ.

Objective Through observing clinical effects of Western medicine,Chinese medicine and Chinese combined with western medicine in the treatment of depressive disorder (DD),the author tried to investigate a safer,more effective and obedient therapeutic method. Methods 120 DD patients were randomly recruited into three groups.Patients in group A were orally given clomipramine 25mg,3/d and Jieyu Huatan mixture 50ml,2/d;Patients in group B were orally given Jieyu Huatan mixture 50ml,2/d;Patients in group C were orally given clomipramine 25rag,3/d.After 6 weeks,Hamilton's depression (HAMD) and treatment emergent symptom scale (TESS) scale were used to assess the efficacy and safety.Results Altogether116 patients completed the whole treatment.Total clinical effective rate,effective rate of symptom improvement,and HAMD total cut-rate were 95.00%,92.50%,69.13±29.47% in the group A,69.23%,64.10%,53.22±25.78 % in the group,and 70.27%,64.87%,53.47±26.29% in the group C respectively.Patients in the group A were significantly better than the other two groups (P＜0.01) in terms of the indications mentioned above,while no significant difference showed between the group B and the group C (P＞0.05).Meanwhile the TESS score in the group A and B was lower than the group C (P＜0.01),and there was no significant difference between the group A and the group B (P＞0.05).Conelusion The treatment of Jieyu Huatan mixture combined with clomipramine is more effective and faster onset of action,having fewer side effects and reasonable cost.This method is a good way in the treatment of depressive disorder.

Stomatology is an applied science,and experimental teaching plays an important role in training renovation talents.A complete construction of the laboratory system is a complex systematic project,which requires the right teaching conception,advanced experimental instruments,high-quality teachers of laboratory,the optimization of the teaching contents,as well as highly efficient operating mechanism and management approach.It is also a process of exploration and innovation.

BACKGROUND:Nano-hydroxyapatite/col agen combined with mononuclear cel s can promote the growth of a variety of stem cel s to induce the formation of new bone and vascularization, final y inducing osteogenesis.
OBJECTIVE:To investigate the feasibility of bone marrow mononuclear cel s combined with the nano-hydroxyapatite/col agen for repair of mandibular defects in a rabbit.
METHODS:Twenty-seven New Zealand white rabbits were selected to prepare bilateral mandibular bone defect models, and then divided into three groups. In experiment group, bone marrow mononuclear cel s combined with the nano-hydroxyapatite/col agen were implanted into mandibular defects;in control group, nano-hydroxyapatite/col agen scaffold was implanted;and in blank control group, nothing was implanted. Tissue specimens were prepared at weeks 4, 8, 12 for gross observation, imaging analysis, hematoxylin-eosin staining and scanning electron microscope.
RESULTS AND CONCLUSION:The imaging examination and histological staining showed that the bone quality and healing degree in the experimental group was better than those in the other groups. Scanning electron microscope showed that better histocompatibility and no inflammation reaction in the experimental group. Dental CT data showed that the experimental group had better repair effect than the other groups (P<0.05). These findings indicate that bone marrow mononuclear cel s combined with the nano-hydroxyapatite/col agen have capacity of bone induction and bone formation, which can be used to repair mandibular defects.

Objective To investigate the effects of regional infusion of hypothermic normal saline contained captopril on free radicals level and myeloperoxidase(MPO) activity in rabbits during spinal cord ischemia-reperfusion(I/R).Methods The 80 rabbits were randomly divided into four equal groups,group A(sham operated,no I-R injury,n=8),group B(control,only I/R,n=24),group C(I/R + intraaortic hypothermic normal saline,n=24),and group D(I/R + N.S plus 4mg/kg captopril,n=24).The model of spinal cord ischemia in the rabbit was induced with the aorta clamped.Hypothermic solution was infused into the isolated aortic segments.The content of spinal cord MDA and the activities of superoxide dismutase(SOD),MPO were measured at 8h,24h and 72 h after the reperfusion respectively.Results The level of spinal cord MDA increased,the activity of SOD decreased and the activity of MPO increased markedly after the reperfusion.Compared with group B,the MDA content decreased significantly at the three observation time points and the MPO activity decreased significantly in groups C and D(all P

Objective To investigate the effect of regional captopril infusion on ischemia-reperfusion (I-R) injury of spinal cord in rabbits. Methods 32 rabbits were divided randomly into four groups, the group A (sham operated, no I-R injury), the group B (control group, only with I-R injury), the group C (I-R injury + intra-aortic infusion of hypothermic normal saline), and the group D (I-R injury + infusion of normal saline plus 4mg/kg captopril). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Hemodynamic data were measured in every group. The spinal cord function was assessed 24, 48 and 96 hours after aortic declamping according to Tarlov's Scale. Spinal cords were harvested for histological analysis. Results There were no significant differences in blood pressure and heart rate among four groups. The neurological status in the groups C and D was significantly superior to that of the group B (P<0.01). In the group B, all animals were paraplegic with Tarlov's Scale of 0 or 1. Three of 8 animals in the group C were paraplegic with Tarlov's Scale of 0 or 1, and only one animal in the group D. Compared to the group B, there were more normal neurons in the anterior horn of spinal cords in the groups C and D (P<0.01). Conclusion Regional infusion of hypothermic normal saline contained captopril can provide sufficient spinal cord protection against ischemia.

Objective To study the effect of selection of indications in percutaneous laser disc decompression(PLDD).Methods Lumbar disc herniation treated by PLDD with satisfactory and unsuited indications in 34 cases respectively were matched studied.Results The curative effect was 85.3% and 55.9% in satisfactory indication group and unsuited indication group respectively (?~2=5.06,P

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Objective To investigate the value of quantitative assessment of hepatic fibrosis and indocyanine green measurement in predicting hepatic functional reserve in rats with liver cirrhosis.Methods Female Wister rats were divided into normal control and cirrhotic group,and cirrhotic models were established.Quantitative assessment of hepatic fibrosis was done by use of computer-assisted digital image analysis,and R15ICG was measured.Results Differences of R15ICG and quantitative assessment of hepatic fibrosis between the two groups at 8 and 10 weers after hepatic fibrosis model was established were statistically significant(P

0.05)was found in the2groups.The costs of the2groups were1059.73yuan(RMB)?2304.26yuan(RMB)respectively;the cost-effectiveness ratios of the2groups were11.62?25.70respectively;the total cost in the course of treatment for the pantoprazole group was1244.53yuan(RMB)less than the omeprazole group.In the sensitivity analysis,the cost-effectiveness ratios of the2groups were10.51?23.22respectively.CONCLUSION:Pantoprazole is an economical and effective drug for the prevention of stress ulcer in ICU patients.