The mongrel dogs, anesthetized with pentobarbital sodium, were used as experimental animals. The effects of a single intravenous injection of ethyl adrianol. 0.5 mg per kg of body weight, on cardiovascular response and urinary flow were compared with those of epinephrine, 0.05 mg per kg of body weight and norepinephrine, 0.05 mg per kg of body weight. 1) The pressor effect induced with 0.5 mg of ethyl adrianol per kg of body weight was similar to that with equipressor doses, 0.05 mg, kg of epinephrine or norepinephrine. 2) The duration of the pressor action of ethyladrianol lasted at least one hour but only about 15minutes with equipressor dose of epinephrine or norepinephrine. 3) Ethyladrienol was responsible for the increase of the urinary volume, which phenomenon is assumed to be related of the renal-function and the durability of the reaction. 4) Ethyladrianol is considered to be one of the ideal drugs for the treatment of hypotensive shock.
Animals ; Body Weight ; Dogs* ; Epinephrine ; Etilefrine* ; Injections, Intravenous ; Norepinephrine ; Pentobarbital ; Shock