Although most of the maxillary sinus retention cysts are asymptomatic, a few of them increase in size and cause symptoms. However, they rarely erode bony walls nor protrude into the inferior meatus. I present 2 cases with maxillary sinus retention cysts protruding into the inferior meatus by making a large defect on the medial wall of the maxillary sinus.
Cytochrome P-450 CYP1A1 ; Maxillary Sinus*

We have reported a case of dumbbell shaped maligfnant melanoma which developed and formed a large mass(2x7x5 cm) in the frontal scalp at the midline, eroded the bone, and invaded directly into the epidural region through the bony defect and formed another large tumor(3x7x8 cm) in the frontal fossa. Several small nodules of malignant melanoma were found in the anterior chest wall, too. In spite of the huge mass in the frontal fossa the case developed only dull headache without any neurological deficits. The frontal mass was successfully excised, of which pathological finding showed malignant melanoma.
Cytochrome P-450 CYP1A1 ; Headache ; Melanoma* ; Scalp ; Thoracic Wall

A 40-year-old woman presented with a pruritic erythematous eroded patch on the right labium majus which had been for 3 years. Histopathological findings were consistent with superficial basal cell epithelioma. Basal cell epithelioma of the labium majus is a rare neoplasm and its clinical appearance is usually nodular. In contrast to the other types of basal cell epithelioma, the superficial type occurs mainly on the trunk. We report a case of superficial basal cell epithelioma arising from the labium majus.
Adult ; Carcinoma, Basal Cell* ; Cytochrome P-450 CYP1A1 ; Female ; Humans

We reported the two cases of olecranon osteomyelitis secondary to the iatrogenic chronic relapsing septic olecranon bursitis. Infection was well eradicated by excision of the infected bursa and curettage of the eroded olecranon under the coverage of antibiotic therapy.
Bursitis* ; Curettage ; Cytochrome P-450 CYP1A1 ; Olecranon Process* ; Osteomyelitis*

The dental profession is currently experiencing a technology explosion. Processes are being replaced by modern, inexpensive, and precise techniques that can be used to solve complex restorative problems. Electrical discharge machining (DEM, known as spark erosion in Europe) is a nonconventional, industrial technique that has application in dentistry. EDM may be defined as a metal removal process using a series of sparks to erode material from a workpiece in a liquid medium under carefully controlled conditions. EDM is recently adopted in the dental laboratory to fabricate precision attachments, hybrid telescope crowns, Ti-ceramic crowns. EDM has also been used to achieve a passive precision metalto-metal fit between the substructure bar and the removable superstructure and to correct the fit of implant retained restorations. in this article, a brief history and explanation of EDM is discussed and a description of the use of this process for fabricating attachments and crowns or for correcting the fit of cast restorations is presented.
Crowns ; Cytochrome P-450 CYP1A1 ; Dentistry ; Explosions ; Laboratories, Dental ; Telescopes

Vertebral fractures and trabecular bone loss have dominated thinking and research into the pathogenesis and the structural basis of bone fragility during the last 70 years. However, 80% of all fractures are non-vertebral and occur at regions assembled using large amounts of cortical bone; only 20% of fractures are vertebral. Moreover, ~80% of the skeleton is cortical and ~70% of all bone loss is cortical even though trabecular bone is lost more rapidly than cortical bone. Bone is lost because remodelling becomes unbalanced after midlife. Most cortical bone loss occurs by intracortical, not endocortical remodelling. Each remodelling event removes more bone than deposited enlarging existing canals which eventually coalesce eroding and thinning the cortex from 'within.' Thus, there is a need to study the decay of cortical as well as trabecular bone, and to develop drugs that restore the strength of both types of bone. It is now possible to accurately quantify cortical porosity and trabecular decay in vivo. The challenges still to be met are to determine whether measurement of porosity identifies persons at risk for fracture, whether this approach is compliments information obtained using bone densitometry, and whether changes in cortical porosity and other microstructural traits have the sensitivity to serve as surrogates of treatment success or failure.
Cytochrome P-450 CYP1A1 ; Densitometry ; Humans ; Osteoporosis ; Porosity ; Skeleton ; Thinking

We reported the two cases of olecranon osteomyelitis secondary to the iatrogenic chronic relapsing septic olecranon bursitis. Infection was well eradicated by excision of the infected bursa and curettage of the eroded olecranon under the coverage of antibiotic therapy.
Bursitis ; Curettage ; Cytochrome P-450 CYP1A1 ; Olecranon Process ; Osteomyelitis

Myxomas of the maxillary sinus are rare but well described mesenchymal neoplasms. They may be related to dental malformations or missing teeth, but may also occur without any such abnormalities. Although these tumors are well circumscribed, they are often more extensive than apparent because of their local aggressiveness and ability to erode bone. They tend to recur despite their benign nature, so it should be widely resected to prevent recurrence. A brief overview of the literature and a report of a case of myxoma of the maxillary sinus is presented.
Cytochrome P-450 CYP1A1 ; Maxillary Sinus* ; Myxoma* ; Recurrence ; Tooth

Most chemical carcinogens are metabolized and activated in vivo by phase I enzymes including the microsomal cytochromes P450 and epoxide hydroxylases. The carcinogens and their metabolites are detoxified by phase II enzymes that include various transferases such as glutathion-S-transferases (GST). Increasing numbers of studies have demonstrated the association of the polymorphisms in GSTM1 (a member of GST) and CYP1A1 genes with the susceptibility to lung cancer. Subsequently, the polymorphisms appear to be important biomarkers that provide information for assessment of exposure and total burden of environmental carcinogens. Therefore, the investigation of the polymorphisms in these genes will provide information not only for the prediction of individual cancer risk but also for the prevention of cancer. In this review, we will summarize the polymorphisms in the GSTM1 and CYP1A1 genes and their relation to lung cancer susceptibility.
Malignant neoplasm of lung ; seconds ; CYP1A1 gene ; GST Gene ; Cytochrome P-450 CYP1A1

Flavonoids are present in fruits, vegetables and beverages derived from plants, and in many dietary supplements or herbal remedies. A number of naturally occurring flavonoids have been shown to modulate the CYP450 system, including the induction or inhibition of these enzymes. This review focuses on the flavonoid effects on cytochrome P450 (CYP) enzyme CYP1, 2E1, 3A4 and 19. Flavonoids alter CYPs by various mechanisms, including the stimulation of gene expression via specific receptors and/or CYP protein, or mRNA stabilization and so on. But in vivo and in vitro, the effects of flavonoids are not always coincident as a result of concentrations of flavonoids, genetic and environmental factors. As well, flavonoids may interact with drugs through the induction or inhibition of their metabolism. Much attention should be paid to the metabolism interaction of the flavonoids when coadministered with other drugs.
Animals ; Aromatase ; genetics ; metabolism ; Cytochrome P-450 CYP1A1 ; antagonists & inhibitors ; genetics ; metabolism ; Cytochrome P-450 CYP2E1 ; genetics ; metabolism ; Cytochrome P-450 CYP2E1 Inhibitors ; Cytochrome P-450 CYP3A ; genetics ; metabolism ; Cytochrome P-450 CYP3A Inhibitors ; Cytochrome P-450 Enzyme Inhibitors ; Cytochrome P-450 Enzyme System ; genetics ; metabolism ; Enzyme Activation ; drug effects ; Flavonoids ; pharmacology ; Humans ; RNA, Messenger ; genetics ; metabolism