1.Clinical investigation on the correlation between lower urinary tract infection and cystitis glandularis.
Zhiqiang, CHEN ; Zhangqun, YE ; Wei, ZENG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2004;24(3):303-4
In order to study the association between lower urinary tract infection and cystitis glandularis (CG), 120 cases of CG were diagnosed by cystoscopic biopsy in the suspicious foci of the bladder. Among them, 72 cases were subjected to bacterial counting culture of urine and microscopic examination of urinary sediment, and 60 cases to fluorescence quantitative polymerase chain reaction (FQ-PCR) assay to detect HPV, CMV and HSV DNA in urine samples. In the 72 cases of CG, the positive rate of bacterial counting culture of urine was 15.3% (11/72), and gray zone rate was 18.1% (13/72). 31.9% (23/72) patients were positive in bacterioscopy of urinary sediment. There was statistically significant difference as compared with the control group (P<0.01). Only 4 of 60 urine samples were positive by FQ-PCR in detection of the three viruses mentioned above with the positive rate being 6.67%. Compared with the control group, there was no significant difference (P>0.05). It was concluded that the genesis of CG was closely correlated with the chronic lower urinary tract infection, especially caused by Esch coli.
Cystitis/etiology
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Cystitis/microbiology
;
Cystitis/*pathology
;
*Escherichia coli Infections
;
Metaplasia
;
Urinary Bladder/microbiology
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Urinary Bladder/*pathology
;
Urinary Tract Infections/complications
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Urinary Tract Infections/*microbiology
;
Urinary Tract Infections/pathology
2.Clinical differential diagnosis of type III prostatitis and interstitial cystitis.
Tie-Jun LIU ; Meng-Jie ZHAO ; Ke-Fu SHA ; Ju-Zhong GAO
National Journal of Andrology 2009;15(2):140-143
OBJECTIVETo investigate the differential diagnosis of type III prostatitis and interstitial cystitis so as to improve the efficiency of diagnosis and treatment of the two diseases.
METHODSBased on the clinical data of 4 cases of type III prostatitis and 3 cases of interstitial cystitis, we analyzed the characteristics of the two diseases in such aspects as clinical symptomatology, urodynamics, prostatic fluid microscopy, microbiology and treatment.
RESULTSThe common clinical characteristics of type III prostatitis and interstitial cystitis were indisposition or pain in the subabdomen and/or pelvic floor, but their differences were quite obvious. In interstitial cystitis, longer urine accumulation could cause worse pain in the subabdomen, which could be relieved after micturation, and the bladder capacity was obviously decreased, but with normal prostatic fluid and negative result of microbial culture. It responded to behavior therapy, resiniferatoxin, sodium hyaluronate and water dilation of the bladder under anaesthesia. While type III prostatitis, with white blood cells > 10/HP or < or = 10/HP in the prostatic fluid and negative result of microbial culture, did not respond to the above therapeutic methods that were effective for interstitial cystitis.
CONCLUSIONType III prostatitis and interstitial cystitis, although clinically confusable, can be definitely differentiated from each other according to their characteristic causes and locations.
Adult ; Aged ; Cystitis, Interstitial ; diagnosis ; etiology ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Prostatitis ; complications ; diagnosis
3.Two cases of lupus cystitis and literature review.
Yisha LI ; Hui LUO ; Yanli XIE ; Xiaoxia ZUO
Journal of Central South University(Medical Sciences) 2011;36(8):813-816
OBJECTIVE:
To improve the understanding of lupus cystitis.
METHODS:
Clinical manifestations, laboratory Results , and image information of 2 cases of lupus cystitis were analysed retrospectively, and another 6 cases in the literature were reviewed.
RESULTS:
Two patients were female. The urinary symptoms followed the gastrointestinal symptoms. Ureterectasia and hydronephrosis were detected in both patients, and intestinal pseudo-obstruction was detected in one patient. In the 6 cases from the literature, ureterectasia and hydronephrosis were detected in all patients, and intestinal pseudo-obstruction was detected in 4.
CONCLUSION
The possibility of lupus cystitis should be considered when lupus patients complain of urinary or bowel symptoms. Glucocorticoid and immunodepressant are effective for lupus cystitis.
Adolescent
;
Adult
;
Cystitis
;
complications
;
diagnosis
;
Female
;
Humans
;
Hydronephrosis
;
etiology
;
Lupus Erythematosus, Systemic
;
complications
;
diagnosis
;
Ureter
;
pathology
4.Etiological study on cystitis glandularis caused by bacterial infection.
Xiaogang, LIU ; Zhiqiang, CHEN ; Zhangqun, YE
Journal of Huazhong University of Science and Technology (Medical Sciences) 2007;27(6):678-80
To study the relationship between bacterial infection and the etiology of cystitis glandularis, 36 female Wistar rats were divided into 3 groups. No intervention was given to the rats in the blank group. NS was infused into the bladder of the rats of the control group, and solution containing E. coli was injected into the bladder of experimental group. Three months later, tissue samples of bladder were collected and observed visually and under light microscope. The results showed that tissues of the blank group were normal; one sample in the control group showed Brunn's nests and cystitis cystica, and 10 in the experimental group had the change of cystitis glandularis. Compared to the blank and control group, samples in the experimental group showed significant change (P<0.05). There were no significant difference between blank group and control group (P>0.05). It is concluded that bladder instillation of E. coli can induce cystitis glandularis, which confirms that infection is the cause of cystitis glandularis.
Cystitis/etiology
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Cystitis/*microbiology
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Cystitis/*pathology
;
Escherichia coli Infections/*pathology
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Rats, Wistar
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Urinary Bladder/microbiology
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Urinary Bladder/*pathology
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Urinary Tract Infections/complications
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Urinary Tract Infections/*microbiology
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Urinary Tract Infections/pathology
5.Immune-related late-onset hemorrhagic cystitis post allogeneic hematopoietic stem cell transplantation.
Xiao-jun HUANG ; Dai-hong LIU ; Lan-ping XU ; Hong-yu ZHANG ; Kai-yan LIU
Chinese Medical Journal 2008;121(18):1766-1769
BACKGROUNDThe pathophysiology of late-onset hemorrhagic cystitis (LOHC) is currently not well understood. The aim of this study was to analyze the alloimmune aetiology in the pathogenesis of LOHC post allogeneic hematopoietic stem cell transplantation (HSCT).
METHODSA retrospective study was performed on the medical records of 11 patients with immune-related LOHC post allogeneic HSCT. The clinical characteristics, therapy, and outcomes of these patients were analyzed.
RESULTSThe median time of onset was 42 days after HSCT (range 16-150 days) and the median duration of HC was 43 days (range 29-47 days). All patients presented with prolonged HC for more than 35 days. Nine patients with evidence of cytomegalovirus (CMV) reactivation did not respond to anti-viral therapy even with CMV clearance in the urine post-therapy. Eleven patients with refractory HC received a low dose of corticosteroids and all patients went into complete remission.
CONCLUSIONOur data suggest that alloimmune injury is involved in the pathogenesis of HC in at least some patients and that specific therapy might improve the clinical outcome of hemorrhagic cystitis.
Autoimmune Diseases ; etiology ; Cystitis ; etiology ; Hematopoietic Stem Cell Transplantation ; adverse effects ; Hemorrhage ; etiology ; Humans ; Leukemia ; therapy ; Retrospective Studies ; Transplantation, Homologous ; adverse effects
6.Analysis of the Risk Factors for Hemorrhagic Cystitis after Hematopoietic Stem Cell Transplantation.
Chun-Hong SUN ; Xiao-Ning WANG ; Min-Na LUO ; Cai-Li GUO ; Shi-Huan QI ; Bei-Rong ZHANG ; Fang WANG ; Huan ZHANG ; Peng-Cheng HE
Journal of Experimental Hematology 2021;29(2):610-614
OBJECTIVE:
To analyze the risk factors affecting hemorrhagic cystitis(HC) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).
METHODS:
The clinical data of 153 patients underwent allogeneic hematopoietic stem cell transplantation in the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2018 were selected and retrospectively analyzed. The incidence, median time and treatment outcome of HC should be observed. Multivariate analysis was used to observe the risk factors of HC in patients, including sex, age, diagnosis, disease status before transplantation, transplantation type, ATG and CTX in the pretreatment scheme, stem cell source, neutrophil and platelet implantation time; CMV, EBV and BKV infection, and acute graft-versus-host disease(aGVHD).
RESULTS:
Among 153 patients underwent allogeneic hematopoietic stem cell transplantation, 25 (16.34%) patients had HC, the median occurance time was 31 days, all patients achieved complete remission after treatment, no bladder irritation and bladder contracture were left. The results of univariate and multivariate Logistic regression analysis showed that the type of transplantation, ATG, CMV viremia before treatment, aGVHD (r=1.036, 3.234, 3.298 and 2.817, respectively) were the independent risk factors of HC.
CONCLUSION
The urinary BKV detections in the patients with HC are positive, mainly occured during the period from day +13 to days +56. HLA haplotype, pretreatment including ATG, and CMV viremia, and aGVHD are the independent risk factors for HC after allo-HSCT.
Cystitis/etiology*
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Graft vs Host Disease
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Hematopoietic Stem Cell Transplantation/adverse effects*
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Humans
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Retrospective Studies
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Risk Factors
7.Masked Hydronephrosis.
Lae Young JUNG ; Kyung Pyo KANG ; Won KIM ; Sung Kwang PARK ; Sik LEE
The Korean Journal of Internal Medicine 2012;27(2):244-244
No abstract available.
Aged
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Colitis, Ischemic/complications/*diagnosis/therapy
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Cystitis/*diagnosis/etiology
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Dehydration/etiology
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Diarrhea/etiology
;
Female
;
Fluid Therapy
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Humans
;
Hydronephrosis/*diagnosis/etiology
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Oliguria/etiology
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Predictive Value of Tests
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Radiation Injuries/*diagnosis/etiology
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Tomography, X-Ray Computed
10.Analysis of risk factors for the development of hemorrhagic cystitis post allogeneic hematopoietic stem cell transplantation.
Hong-Yu ZHANG ; Xiao-Jun HUANG ; Lan-Ping XU ; Dai-Hong LIU ; Kai-Yan LIU ; Wei HAN ; Huan CHEN ; Yu-Hong CHEN ; Dao-Pei LU
Chinese Journal of Hematology 2007;28(4):243-246
OBJECTIVETo analyze the incidence and risk factors of hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT).
METHODSThe medical records of 250 patients undergoing allogeneic HSCT in Peking University Institute of Hematology from Sep. 2003 to Sep. 2005 were analyzed.
RESULTSHC occurred in 72 of the 250 patients within 180 days after transplantation with a cumulative incidence of 28.8% (SE 0.3%). None of early-onset HC was developed in the cohort. The median time of onset was 33 days after HSCT (range 14 - 170 days) and the median duration of HC was 35 days (range 3 -186 days). There were HC of grade I - II in 51/72 cases (70.83%) and of grade III - IV in 21/72 (29.17%). Univariate analysis indicated that age younger than 25, high risk disease, CMV reactivation, ATG usage, graft from MUD or MMRD and GVHD grade IL - IV were associated with the occurrence of HC, while in multiple regression analysis only GVHD grade II - IV (RR = 2.75; 95% CI 1.63 -4.66; P < 0.01) and donor type (RR = 2.60; 95% CL 1.52 - 5.20; P < 0.01) were independent risk factors. Kaplan-Meier survival analysis indicated HC not increasing the mortality (RR = 0.67, 95% CI 0.33 - 1.36).
CONCLUSIONHC post allo-HSCT is a common complication, GVHD grade II - IV and donor type are the independent risk factors.
Cystitis ; epidemiology ; etiology ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation ; Humans ; Incidence ; Postoperative Complications ; epidemiology ; etiology ; Retrospective Studies ; Risk Factors ; Transplantation, Homologous