No abstract available.
Cystatin C* ; Hemoglobin A, Glycosylated* ; Humans

No abstract available.
Cardiovascular Diseases ; Cystatin C ; Humans

No abstract available.
Coronary Artery Disease ; Coronary Vessels ; Cystatin C

No abstract available.
Adult* ; Cystatin C* ; Hemoglobin A, Glycosylated* ; Humans

No abstract available.
Adult* ; Cystatin C* ; Hemoglobin A, Glycosylated* ; Humans

PURPOSE: Early detection of diabetic nephropathy is very important for prevention of renal failure. Determination of microalbuminuria has been suggested as an early predictor of diabetic nephropathy, but it is tend to be erroneous and inaccurate, especially in childhood. The aim of this study is to show clinical values of serum cystatin C and beta(2)-microglobulin in the assessment of renal function in diabetic children and adolescents. METHODS: Ninety four type 1 and 2 diabetic patients with normoalbuminuria (n=78), microalbuminuria (n= 15) and macroalbuminuria (n=1) were enrolled. Serum concentration of cystatin C, beta2-microglobulin, creatinine, urinary microalbumin levels and creatinine clearances were determined. RESULTS: In patients with microalbuminuria, serum concentration of cystatin C was increased significantly in comparison to patients with normoalbuminuria (P<0.05), while no differences were observed for beta2- microglobulin levels. Serum creatinine concentrations were not different between both groups. Serum concentration of cystatin C was positively correlated with serum beta2-microglobulin and serum creatinine. The serum concentration of beta2-microglobulin was not correlated with the decrease of renal function significantly. CONCLUSION: Serum cystatin C is a useful endogenous marker in assessment of renal function in pediatric diabetic patients.
Child ; Creatinine ; Cystatin C ; Diabetic Nephropathies ; Humans ; Renal Insufficiency

BACKGROUND: Cystatin C, a 13-kDa protein synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine in assessments of renal function. The Gentian Cystatin C immunoassay (Gentian, Norway) was recently developed using particle enhanced turbidimetric immunoassay. In this study, we evaluated the analytical performance of the Gentian Cystatin C immunoassay on the Hitachi 7600 Automatic Analyzer (Hitachi Ltd., Japan). METHODS: We performed precision and linearity studies using Hitachi Clinical Analyzer 7600 with Gentian reagent and compared the results to those obtained with the N Latex Cystatin C (Siemens, Germany) using a particle enhanced nephelometric immunoassay method performed on the Behring Nephelometer II (Siemens, Germany). We also analyzed the traceability of Gentian reagent and Siemens reagent to Cystatin C standard reference material, ERM-DA471/IFCC. RESULTS: The coefficient of variations (CVs) for within-run imprecision at low and high levels were 1.58% and 1.06% and the CVs for total imprecision at low and high levels were 2.53% and 2.09%, respectively. In the linearity test, the coefficient of determination (R2) was 0.9997 (range, 0.23 to 7.50 mg/L), and comparison with the results obtained by Siemens reagent showed an excellent correlation coefficient of 0.9982. In the traceability test, Gentian reagent is more accurate than Siemens reagent and the total accuracy was 96.0%. CONCLUSIONS: Gentian reagent provides good analytic performance on the Hitachi 7600 Automatic Analyzer and can be used for the diagnosis, treatment, monitoring, and risk assessment of renal function.
Creatinine ; Cystatin C* ; Diagnosis ; Gentiana* ; Immunoassay ; Latex ; Methods ; Risk Assessment

No abstract available.
Coronary Artery Disease ; Coronary Vessels ; Cystatin C ; Humans

No abstract available.
Coronary Artery Disease ; Coronary Vessels ; Cystatin C ; Humans

No abstract available.
Cystatin C* ; Female ; Filtration* ; Humans ; Kidney* ; Pregnant Women*