Cystadenocarcinoma of the salivary gland is a rare malignant tumor. It was first defined as papillary cystadenocarcinoma in the 1991 World Health Organization (WHO) classification, and it was reclassified as cystadenocarcinoma in the 2005 WHO classification. It is a low-grade neoplasm that features slow growing and predominantly cystic growth. We report a case of cystadenocarcinoma occurring on the parotid gland of a 61-year-old female patient presenting palpable mass on her left cheek. Preoperative examination may not reveal typical malignant characteristics. Such as in our case, the differential diagnosis between cystadenocarcinoma and benign lesion is difficult occasionally. We discuss the clinical and histopathological features of cystadenocarcinoma with the review of the literature.
Cheek ; Cystadenocarcinoma* ; Cystadenocarcinoma, Papillary ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Parotid Gland ; Salivary Glands ; World Health Organization

Salivary gland papillary cystadenocarcinomas are rare lesions, and particularly when they are found in the oral cavity. They have been recognized as being low grade carcinomas of the salivary glands. The author reports here on a case of recurrent papillary cystadenocarcinoma in the right retromolar area. The initial mass had multicystic and papillary structures with low grade features. The recurred mass showed basically the same histologic features. However the layer of papillae and the solid portion were increased and the tumor cells were larger and more pleomorphic with prominent nucleoli and frequent mitoses. Focal comedo type tumor necrosis and spindle cell proliferations in the surrounding soft tissue were present. This is a very rare report of a minor salivary gland papillary cystadenocarcinoma in a Korean, and the morphologic dedifferentiation was accompanied by the clinical recurrence.
Cystadenocarcinoma, Papillary* ; Mitosis ; Mouth ; Necrosis ; Recurrence ; Salivary Glands ; Salivary Glands, Minor

Papillary cystadenocarcinoma originated from salivary gland is a lower grade neoplasm that rises most commonly in major salivary glands, although involvement of lip, palate, buccal mucosa and tongue has also been described. Papillary cystadenocarcinoma was first defined in 1991 by WHO. Until then, it was classified as an atypical type of adenocarcinoma. We experienced a case of papillary cystadenocarcinoma of the submandibular gland, so we report this case with a review of the literature.
Adenocarcinoma ; Cystadenocarcinoma, Papillary* ; Lip ; Mouth Mucosa ; Palate ; Salivary Glands ; Submandibular Gland Neoplasms ; Submandibular Gland* ; Tongue

Papillary cystadenocarcinoma is a very rare malignant neoplasm of the salivary gland. We report a case of papillary cystadenocarcinoma arising from the minor salivary gland in the retromolar trigone of a 56-year-old female patient presenting intermittent hemorrhage from the oral cavity. We discuss the clinical and histopathological features of the papillary cystadenocarcinoma of the salivary gland with the review of the literature.
Cystadenocarcinoma, Papillary* ; Female ; Hemorrhage ; Humans ; Middle Aged ; Mouth ; Salivary Glands ; Salivary Glands, Minor*

This is a report of ovarian carcinoma occurring in two sisters diagnosed almost at the same time, prompting prophylactic oophorectomy in a third sister. Histology of the overtly normal ovary in the third sister showed a focus of ovarian cancer. Discussion and a review of the literature suggest that any program designed to reduce the incidence of late-stage ovarian carcinoma should include the surveillance of family members of the index case, including the performance of prophylactic oophorectomy in the unaffected members of the family after they have completed their families.
Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Combined Modality Therapy ; Cystadenocarcinoma, Papillary - diagnosis

Cystic lesions of the pancreas are being incidentally recognized with increasing frequency and become a common finding in clinical practice. Despite of recent remarkable advances of radiological and endoscopic assessment and a better understanding of natural history of certain subgroups of cystic lesions, differentiating among lesions and making an optimal management plan is still challenging. A multimodal approach should be performed to evaluate incidentally detected cystic lesions. Emerging evidence supports selective nonoperative management for the majority of patients with cystic lesions, but, for those in whom a suspicion of malignancy remains, surgery is indicated. Concerning long-term follow-up, there is limited data to support the ideal modality, intensity, and duration. Therefore, evidence-based guidelines for the diagnosis, management, and follow-up of cystic lesions of the pancreas should be established.
Cystadenocarcinoma, Mucinous/diagnosis/epidemiology/therapy ; Cystadenocarcinoma, Papillary/diagnosis/epidemiology/therapy ; Cystadenocarcinoma, Serous/diagnosis/epidemiology/therapy ; Humans ; Incidence ; Incidental Findings ; Pancreatic Cyst/*diagnosis/epidemiology/therapy ; Pancreatic Neoplasms/*diagnosis/epidemiology/therapy ; Tomography, X-Ray Computed ; Tumor Markers, Biological/blood

papillary projections are diagnostic. However, salivary gland tumor is particularly difficult to interpret. Primarily, as further clinical and histological differential diagnoses have to take into account the mucoepidermoid carcinoma and the papillary cystadenocarcinoma. And also, biologic behavior of this peculiar lesion is uncertain. We report on a 71 year old female with a mucosal lesion at the tongue with its histologic features and differential diagnosis. Post-operative course was uneventful and there was no recurrence sign at this time. However, close follow-up is necessary, because the recurrent cases had been reported in literatures.]]>
Aged ; Carcinoma, Mucoepidermoid ; Cystadenocarcinoma, Papillary ; Cystadenoma ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Recurrence ; Salivary Glands ; Salivary Glands, Minor ; Tongue

OBJECTIVETo study the diagnosis and treatment of Müllerian duct cysts and their involvement with malignancy.

METHODSA 44-year-old male patient with papillary cystadenocarcinoma involving a Müllerian duct cyst was presented. The presentation treatment, and pathological and radiological appearances were retrospectively analysed and discussed with literature review. The main manifestation was intermittent episode of hemospermia accompanying terminal hematuria and infertility for 15 years. Final diagnosis was determined by the findings of transrectal ultrasound scan, CT scan, MRI imaging, cystoscopic examination and biopsy.

RESULTSExploratory laparotomy was performed through a suprapubic retrovesical approach. The finding that a duct-like wedge of tumor tissue passed through the prostate near cyst neck to the posterior urethra without affecting the adjacent prostatic tissue during tylectomy confirmed that it arises from Müllerian duct system. Pathohistologic examination disclosed a papillary cystadenocarcinoma and it infiltrated the wall of the cyst. Both seminal vesicles and ejaculatory duct had no carcinoma invasion.

CONCLUSIONMüllerian duct cyst involving with malignancy is exceedingly rare, the diagnosis is based on the findings of transrectal ultrasound scan, CT scan, MRI imaging, cystoscopic examination. The final diagnosis depends on the pathohistologic examination. Lumpectomy is effective and have a good outcome.

Adult ; Cystadenocarcinoma, Papillary ; diagnosis ; surgery ; Cysts ; diagnosis ; surgery ; Genital Neoplasms, Male ; diagnosis ; surgery ; Humans ; Male ; Mullerian Ducts

The goal of this study was to evaluate the cytomorphologic features of histologically confirmed uterine papillary serous carcinomas (UPSC) of the endometrium. We reviewed cervicovaginal smears from 12 patients with UPSC who had done their cervical smears at six months to a year earlier before the time of diagnosis; nine smears (75%) were diagnosed as positive for malignancy and three smears (25%) were diagnosed as negative. The cervical smears of patients with UPSC revealed frequent papillary clusters that were composed of large pleomorphic tumor cells with prominent nucleoli in a background of necrosis. Other findings revealed from the tests were relatively frequent single malignant cells and bare nuclei. Although the Pap smear is not a sensitive screening test for endometrial carcinoma, we could depend on it to reveal the cytologic features of UPSC which are fairly characteristic and reliable for a preoperative diagnosis of UPSC. Preoperative identification of this poor prognostic variant of endometrial carcinoma may influence the surgical management of these cases and the choice of adjuvant therapy.
Adenocarcinoma/diagnosis/pathology ; Adult ; Aged ; Carcinoma ; Carcinoma, Squamous Cell/diagnosis/pathology ; Cystadenocarcinoma, Papillary/*diagnosis/*pathology ; Cystadenocarcinoma, Serous/*diagnosis/*pathology ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Necrosis ; Prognosis ; Uterine Neoplasms/*diagnosis/*pathology ; *Vaginal Smears

PURPOSE: To evaluate the usefulness of MRI findings in the differentiation of benign from malignant ovarian lesions. MATERIALS AND METHODS: Using MR findings, 29 surgically proven ovarian masses in 22 patients (14 bilateral tumors) were evaluated Twenty-one benign tumors in 16 patients (5 simple cysts, 4 mucinous cystadenomas, 4 serous cystadenomas, 4 endometriomas, 3 cystic teratomas and 1 tuboovarian abscess), and eight malignant tumors in six patients (4 serous papillary cystadenocarcinomas and 4 mucinous cystadenocarcinomas) were included. MRI was performed with SE T1WI, FSE T2WI and Gd-T1WI. MRI findings of lesion size, thickness of wall and of internal septations, number of internal septations, nodularities, and ancillary findings such as adhesion in the pelvic cavity, dissemination, ascites and lymphadenopathy were retrospectively analyzed. RESULTS: Malignant ovarian lesions were larger (18 cm : 11 cm) and had more internal septations, more solid components and nodularities (63 % : 5 %) than benign lesions. On T1WI, cystic lesions, both benign and malignant, showed low signal intensity. Hemorrhage, fat components and mucin containing lesions showed high signals and solid components and nodularities were isointense with muscle on T1WI. Solid components and nodularities were well-enhanced after gadolinium enhancement. Adhesion (50 % : 10 %), dissemination (38 % : 0 %) and ascites (63 % : 24 %) were more frequent in malignant lesions. CONCLUSION: MRI, especially with gadolinium-enhanced T1W1 is useful in the differentiation of benign from malignant ovarian lesions.
Ascites ; Cystadenocarcinoma, Papillary ; Cystadenoma, Mucinous ; Cystadenoma, Serous ; Endometriosis ; Female ; Gadolinium ; Hemorrhage ; Humans ; Lymphatic Diseases ; Magnetic Resonance Imaging* ; Mucins ; Retrospective Studies ; Teratoma