No abstract available.
Cystadenocarcinoma, Mucinous* ; Mucins*

No abstract available.
Cystadenocarcinoma, Mucinous* ; Humans* ; Mucins*

This is a case of a 54-year-old, perimenopausal, Asian, woman, who presented with an enlarging left breast mass associated with whitish to bloody nipple discharge. A core needle biopsy, done in another institution, showed histologic findings of a mucinous carcinoma with triple negative “basal-like” biomarker status (ER, PR, HER2/neu). Six cycles of neoadjuvant chemotherapy were given after which the subsequent modified radical mastectomy revealed a centrally located, 10.0 cm, well-circumscribed, nodular, ovoid mass on gross examination. Microscopic findings showed tall columnar cells in stratification, tufts and papillary formations, with surrounding abundant extracellular mucin. The individual tumor cells exhibit enlarged, hyperchromatic, basally located nuclei with prominent nucleoli, abundant amphophilic and occasionally oncocytic cytoplasm which contains intracytoplasmic mucin. Based on the histologic features, “basal-like” biomarker expression, and additional immunohistochemical studies (positive CK7, negative CK20 and CDX2), this case demonstrates a pure mucinous cystadenocarcinoma of the breast. In addition to the rare histologic type, this case is exceptional since, despite multiple cycles of neoadjuvant chemotherapy, presence of extensive lymphovascular invasion and axillary lymph node involvement with extranodal extension remain evident.
Cystadenocarcinoma, Mucinous ; Breast Neoplasms

No abstract available.
Cystadenocarcinoma, Mucinous* ; Female* ; Humans ; Mucins*

Humans ; Breast/pathology* ; Cystadenocarcinoma/pathology* ; Cystadenocarcinoma, Mucinous/pathology* ; Female

No abstract available.
Adenocarcinoma ; Cervix Uteri* ; Cystadenocarcinoma, Mucinous ; Female

Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.
Adenocarcinoma, Mucinous ; Breast ; Cystadenocarcinoma, Mucinous ; Female ; Humans ; Mucins ; Prognosis

Cutaneous metastasis from the ovarian cancer has been found to be exceedingly rare. We report a case of a metastatic ovarian mucinous cystadenocarcinoma, which clinically manifested as the epidermal cyst-like skin nodule on the right upper quadrant of abdomen.
Abdomen ; Cystadenocarcinoma, Mucinous ; Humans ; Neoplasm Metastasis ; Ovarian Neoplasms ; Skin

Primary retroperitoneal mucinous cystadenocarcinoma is a rare tumor, and it is similar to its ovarian counterpart, but it is without any evidence of ovarian, pancreatic or any other extra-retroperitoneal origin. The histogenesis of this neoplasm remains uncertain. Mucinous or colemic metaplasia of the retroperitoneal mesothelium has recently been proposed as its origin. A 39-year-old woman was diagnosed with a 13-cm cystic lesion in the left retroperitoneum; this was mucinous cystadenocarcinoma and no primary tumor was identified. We report here on a primary retroperitoneal mucinous cystadenocarcinoma that involved the splenic hilum, and we include a review of literature.
Adult ; Cystadenocarcinoma, Mucinous ; Epithelium ; Female ; Humans ; Metaplasia ; Mucins*

Malignant epithelial neoplasm usually occurs in postmenopausal women, with less than 10% of cases occurring in women under the age of 20. In patients below this age, the majority of ovarian tumors are of germ cell origin and malignant ovarian epithelial tumors are uncommon. We report US & CT imaging in a case of mucinous cystadenocarcinoma in a 17-year-old nullipara who complained of amenorrhea for 45 days and a palpable mass.
Adolescent* ; Amenorrhea ; Carcinoma ; Cystadenocarcinoma, Mucinous* ; Female* ; Germ Cells ; Humans ; Mucins*