No abstract available.
Curcumin*

No abstract available.
Curcumin

No abstract available.
Curcumin ; Pain Management

Study results showed that Rhizomes of Curcuma longga containted flavonoid, curcumine, anthraglycoside, alkaloide... Curcumine were extracted and isolated from the rhizome (dry material) of Curcuma longa with ethanol (0.80%) and with methanol (1,02%). Curcumine and extract of Rhizoma Curcumae longae treated on 10 strains of bacteria and Candida albicans invitro. The results showed that they have strong antibacterial and antifungal activity
Chemistry ; Curcumin ; Divorce

BACKGROUND

Sarcopenia is a multifactorial disease with a progressive decline in skeletal muscle mass, muscle strength, and physical performance. Curcumin is a nutraceutical investigated for its anti-inflammatory and antioxidant properties. It is inexpensive, accessible, and considered a safe and practical approach to help alleviate symptoms of sarcopenia and improve muscle mass and function. Objective: This systematic review aims to obtain more conclusive evidence on the effectiveness of curcumin among adults 40 years and above with sarcopenia in improving muscle pain, strength, performance, and muscle morphology.

This systematic review aims to obtain more conclusive evidence on the effectiveness of curcumin among adults 40 years and above with sarcopenia in improving muscle pain, strength, performance, and muscle morphology.

The review will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. It will focus on any interventional studies on curcumin for adults diagnosed with sarcopenia, with the following outcomes: clinically significant improvement in pain, muscle strength and performance, quality of life, and improvement in muscle morphology. Studies completed until 2024 will be included. The databases to be searched include PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL Plus (EBSCOhost), Embase, and Web of Science. The identified citations will be collated in Zotero and uploaded to Covidence© to be assessed using the eligibility criteria and systematically reviewed by two independent reviewers. The CASP Randomised Controlled Trial Checklist will be utilized to assess the quality of the included studies.

The results will serve as a groundwork for future sarcopenia research among allied health specialists, particularly those in the field of physiotherapy - students, healthcare practitioners, and academicians (PROSPERO registration number: CRD42023448750).

To use HPLC for claborating method of quantifying curcumine in tablet and ointment containing gingiber rhizoma product. Curcumine in domeric tablet and curcumin ointment were quantified by HPLC. In the study schema: establising titration cure, extracting curcumine from samples; evaluating value of the method, accuracy and precision in the analysis on curcumine tablet, the method had got: the precition get to 0,893% accuracy 96,98%, lineal interval 0,1mg/l – 100mg/l; in ointment, precision 1,28%, accuracy 92,42%
Curcumin ; Pharmaceutical Preparations ; Tablets ; Crocus

Studied subjects: dried extract of Asiatic Pennywort Herb - Tumeric, 1kg dried extracts is equivalent 42.5kg fresh materia medica (25kg Centella asiatica and 17.5kg Curcuma longa); The compared compositions contained: content of curcumin 95%, content of asiaticosid 90%. The study provided quality specifications as follows: appearance, loss on drying, the solubility in water and in alcohol, the water-insoluble teside, heavy metals limit, pH, ash, fungus, mould, and microbial limit; phosphorus pesticide residues, qualitative and quantitative determination of triterpene ester glycosides and curcuminoids
Pharmaceutical Preparations ; Curcumin ; Materia Medica

BACKGROUND

Curcumin has been investigated as a potential natural solution to prevent or even treat skeletal muscle decline. There are a number of externally sourced finished products (ie, those imported from other countries) containing curcumin, but high cost limits their usage. The emerging research and development of locally sourced curcumin is an opportunity to produce high-quality oral supplements comparable to existing imported products.

The primary purpose of this study is to determine the effects of oral administration of a local curcumin formulation on skeletal muscle using an animal model that similarly demonstrated the course of human sarcopenia.

Purpose-bred 11- to 12-week-old female Sprague Dawley (SD) rats will be used in this study. SD rats are extensively used in animal models of human diseases and conditions such as diabetes, obesity and sarcopenia. Female rats have been selected because they do not demonstrate more temperature or activity variance and have more stable behavior compared to males. To simulate sarcopenia in this animal model, the tail suspension (TS) method was utilized. The TS method involves decreased hind limb function by suspending the animal’s tail for the duration of treatment. The laboratory animals will be randomized to receive any of the four treatments: (1) low-dose curcumin + vehicle; (2) high-dose curcumin + vehicle; (3) vehicle only; and (4) control (distilled water). The interventions will be subdivided into two: 2-week treatment and 4-week treatment. The gastrocnemius muscles on both sides will be excised and weighed, and the muscle tissues subjected to rapid freezing in acetone-dry ice and sliced into 10 μm-thick sections for staining. Examination of muscle architecture and computation of atrophy factors will be performed. The presence of connective tissue, fat tissue and number of atrophic muscle cells will be determined. Accurate quantitative detection of the rat total AMP (adenosine monophosphate)-Activated Protein Kinase will be performed in the gastrocnemius muscle tissue utilizing the enzyme-linked immunosorbent assay kit.

No abstract available.
Animals ; Curcumin* ; Hyperalgesia* ; Ligation* ; Rats* ; Spinal Nerves*

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.
Absorption* ; Biological Availability* ; Curcuma ; Curcumin* ; Metabolism* ; Spices*