No abstract available.
Curcumin*

No abstract available.
Curcumin

Study results showed that Rhizomes of Curcuma longga containted flavonoid, curcumine, anthraglycoside, alkaloide... Curcumine were extracted and isolated from the rhizome (dry material) of Curcuma longa with ethanol (0.80%) and with methanol (1,02%). Curcumine and extract of Rhizoma Curcumae longae treated on 10 strains of bacteria and Candida albicans invitro. The results showed that they have strong antibacterial and antifungal activity
Chemistry ; Curcumin ; Divorce

No abstract available.
Curcumin ; Pain Management

BACKGROUND

Sarcopenia is a multifactorial disease with a progressive decline in skeletal muscle mass, muscle strength, and physical performance. Curcumin is a nutraceutical investigated for its anti-inflammatory and antioxidant properties. It is inexpensive, accessible, and considered a safe and practical approach to help alleviate symptoms of sarcopenia and improve muscle mass and function. Objective: This systematic review aims to obtain more conclusive evidence on the effectiveness of curcumin among adults 40 years and above with sarcopenia in improving muscle pain, strength, performance, and muscle morphology.

This systematic review aims to obtain more conclusive evidence on the effectiveness of curcumin among adults 40 years and above with sarcopenia in improving muscle pain, strength, performance, and muscle morphology.

The review will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. It will focus on any interventional studies on curcumin for adults diagnosed with sarcopenia, with the following outcomes: clinically significant improvement in pain, muscle strength and performance, quality of life, and improvement in muscle morphology. Studies completed until 2024 will be included. The databases to be searched include PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL Plus (EBSCOhost), Embase, and Web of Science. The identified citations will be collated in Zotero and uploaded to Covidence© to be assessed using the eligibility criteria and systematically reviewed by two independent reviewers. The CASP Randomised Controlled Trial Checklist will be utilized to assess the quality of the included studies.

The results will serve as a groundwork for future sarcopenia research among allied health specialists, particularly those in the field of physiotherapy - students, healthcare practitioners, and academicians (PROSPERO registration number: CRD42023448750).

To use HPLC for claborating method of quantifying curcumine in tablet and ointment containing gingiber rhizoma product. Curcumine in domeric tablet and curcumin ointment were quantified by HPLC. In the study schema: establising titration cure, extracting curcumine from samples; evaluating value of the method, accuracy and precision in the analysis on curcumine tablet, the method had got: the precition get to 0,893% accuracy 96,98%, lineal interval 0,1mg/l – 100mg/l; in ointment, precision 1,28%, accuracy 92,42%
Curcumin ; Pharmaceutical Preparations ; Tablets ; Crocus

Studied subjects: dried extract of Asiatic Pennywort Herb - Tumeric, 1kg dried extracts is equivalent 42.5kg fresh materia medica (25kg Centella asiatica and 17.5kg Curcuma longa); The compared compositions contained: content of curcumin 95%, content of asiaticosid 90%. The study provided quality specifications as follows: appearance, loss on drying, the solubility in water and in alcohol, the water-insoluble teside, heavy metals limit, pH, ash, fungus, mould, and microbial limit; phosphorus pesticide residues, qualitative and quantitative determination of triterpene ester glycosides and curcuminoids
Pharmaceutical Preparations ; Curcumin ; Materia Medica

No abstract available.
Animals ; Curcumin* ; Hyperalgesia* ; Ligation* ; Rats* ; Spinal Nerves*

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.
Absorption* ; Biological Availability* ; Curcuma ; Curcumin* ; Metabolism* ; Spices*

Curcumin is exclusively isolated from Zingiberaceae plants with a broad spectrum of bioactivities. In the present study, we used the diketide-CoA synthase (DCS) and curcumin synthase (CURS) genes to construct a non-natural fusion gene encoding diketide-CoA synthase::curcumin synthase (DCS::CURS). This fusion protein, together with the acetyl coenzyme A carboxylase (ACC) and the 4-coumarate coenzyme A ligase (4CL), were introduced into Escherichia coli for the production of curcumin from ferulic acid. The process is divided into two stages, the growth stage using LB medium and the fermentation stage using the modified M9 medium. The yield of curcumin reached 386.8 mg/L by optimizing the induction of protein expression in the growth stage, and optimizing the inoculum volume, medium composition and fermentation time in the fermentation stage, as well as the addition of macroporous resin AB-8 into the second medium to attenuate the toxicity of the end product. The exploitation of the non-natural fusion protein DCS::CURS for the production of curcumin provides a new alternative to further promoting the production of curcumin and the related analogues.
Curcumin/pharmacology* ; Escherichia coli/genetics* ; Fermentation