Objective To investigate the effects of obesity on blood pressure variation and plasma levels of nitric oxide (NO) and endothelin (ET) in elderly hypertensive patients.Methods A total of 175 elderly patients with hypertension were screened for this study.Based on body mass index,they were categorized into three groups with normal weight (n =69),overweight (n=56) and obesity (n=50).24 hour dynamic blood pressure,NO and ET levels were monitored.Results No significant differences in 24 h systolic blood pressure,daytime systolic blood pressure,nighttime systolic blood pressure,24 hours diastolic blood pressure (24 h-DBP) and night time diastolic blood pressure were found among the groups (all P＞0.05).Morning systolic and diastolic blood pressure were higher in obese group than in normal weight and overweight groups(both P＜0.05).The daytime diastolic blood pressure was higher in obese group than in overweight group.24 h systolic blood pressure variation,daytime systolic blood pressure variation,and blood pressure pattern were higher in obese group than in overweight and normal weight group [(12.6 ± 2.7)％ vs.(10.4 ±2.2)％ and (9.4±1.9)％,(12.2±2.9)％ vs.(10.2±2.2)％ and (9.2±2.1)％,(5.2±10.5)％vs.(1.4± 6.9) ％ and (1.8 ± 8.2) ％ group,all P＜ 0.05].The nighttime systolic blood pressure variation,24 h diastolic blood pressure variation,daytime diastolic blood pressure variation were increased in obese group as compared with normal weight group [(9.8 ± 3.7)％ vs.(8.2 ± 3.1)％,(15.3±3.3)％ vs.(13.2±4.2)％,(14.7±3.7)％ vs.(12.9±3.8)％,all P＜0.05].No differences were found in nighttime diastolic blood pressure variation among the groups.Plasma NO level was lower in obese group than in overweight and normal weight group [(29.8± 14.2)μmol/L vs.(47.9± 18.6) μmol/L and (94.6 ± 42.9) μmol/L,P＜0.01].Plasma ET level was significantly higher in obese group than in overweight group and normal weight group [(46.5± 9.8)ng/L vs.(37.3±4.8) ng/L and (31.1± 5.5) ng/L,P＜0.01].24 h systolic blood pressure variation was significantly correlated with plasma NO level (r =0.340,P =0.004) in normal weight group.Conclusions Obesity can effectively increase blood pressure variation and ET level,and reduce plasma NO level in elderly hypertensive patients.Obesity is one of the most important influencing factors for blood pressure variation,plasma NO and ET levels.

Objective To investigate the relationship between urinary iodine level and prevalence of thyroid disease by comparing the levels of urinary iodine in patients with thyroid disease and healthy people in Hefei urban residents.Methods A prospective study was used in the study.A total of 238 patients with thyroid disease were enrolled in the Third Affiliated Hospital of Anhui Medical University from March 2015 to January 2017,and these patients were divided into three groups:Graves's disease (GD) group (n =116),chronic lymphocyticthyroiditis (HT) group (n =79) and thyroid nodule group (n =43),568 cases of Hefei urban residents without thyroid disease were selected as control group Urinary iodine was measured by arsenic-cerium catalyzed spectrophotometry.Thyroid stimulating hormone (TSH),free triiodothyronine (FT3),free thyroxine (FT4),thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were measured by chemiluminescence immunoassay.The thyroid was examined through B ultrasonography in both the case group and the control group.Results The median urinary iodine concentrations(MUIC) of GD group,HT group,thyroid nodule group and control group were 326.83,361.49,235.26,and 195.63 μg/L,there were significant differences in the MUIC between the 4 groups (H =20.13,P ＜ 0.05).The MUIC of GD group and HT group were higher than that of control group (Z =5.395,6.269,P ＜ 0.05).The MUIC was significantly different between the HT group and the thyroid nodule group (Z =3.852,P ＜ 0.05).There were significant differences in TSH,FT3,FT4,TPOAb,TgAb between the GD group and the control group (P ＜ 0.05);the TPOAb and TgAb in the HT group and thyroid nodule group were statistically significantly different compared with those of control group (P ＜ 0.05).There was no correlation between the level of urinary iodine level and FT3,FT4,TSH,TPOAb and TgAb in the 4 groups (P ＞ 0.05).Conclusions According to the urinary iodine level in the normal population,the Hefei urban area belongs to the area of appropriate iodine.There was no corrolation between urinary iodine level and thyroid function in urban residents of Hefei.