Objective To study the association of neuregulin 1(NRG1)gene SNPrs2954041 polymorphisms with schizophrenia and cognitive function.Methods 70 psychiatric patients were selected as observation group, 70 healthy persons were selected as control group.NRG1 gene SNPrs2954041 polymorphism was detected,and the patients'cognitive function and neurological NSS score were evaluated.Results The differences of SNPrs2954041 polymorphism genotype and allele frequencies between the two groups were statistically significant(χ2 =35.412,29.341, all P =0.000).The differences in genotype and allele frequencies between the male observation patients and male control group were statistically significant(χ2 =24.571 ,18.391 ,all P =0.000).The differences in genotype and allelefrequencies between female the observation patients and female control group were statistically significant (χ2 =14.145,13.024,all P =0.000).The difference of memory understanding among the three groups was statistically sig-nificant(F =3.781,P =0.031).The difference of digit span,correct number,errors number,errors continued num-ber,non -sustained errors number in three groups showed no significant differences(F =0.702,0.125,0.089, 0.692,0.113,P =0.498,0.882,0.927,0.512,0.748),the difference of neurological soft signs score of T/T geno-type[(6.79 ±0.55)points],T/G genotype[(6.88 ±0.51 )points]and G/G genotype[(6.53 ±0.39)points]in schizophrenia group was not statistically significant(F =0.142,P =0.843).Conclusion NRG1 gene SNPrs2954041 polymorphism was related to schizophrenia and cognitive function in patients with schizophrenia.

BACKGROUND: Studying the relationship between flexibility and body composition of college students is of great significance for enhancing the levels of physical health and sports. OBJECTIVE: To investigate the relationship between sit-and-reach and body composition of college students in Guangxi Zhuang Autonomous Region and differences between sexes. METHODS: Totally 2 175 students from a Guangxi university were randomly selected. Body composition was determined by the MC-180 body composition tester. The students were divided into four groups: ≤ 12.10 cm group,＞ 12.10-16.40 cm group,＞ 16.40-20.70 group and＞ 20.70 group according to quartile of sit-and-reach measured in accordance with the National Physical Health Test Standard. All data were processed by SPSS 22.0 software. RESULTS AND CONCLUSION: Sit-and-reach was significantly correlated with body mass index, percentage of body fat, fat-free mass index, upper limb lean mass and lower limb lean mass (P ＜ 0.05), and percentage of body fat was negatively correlated with sit-and-reach (P ＜ 0.05). The body mass index, fat-free mass index, upper limb lean mass and lower limb lean mass in the ≤ 12.10 cm group were significantly lower than those in the other groups. Fat-free mass index and upper limb lean mass were correlated with sit-and-reach in male college students (P ＜ 0.05). The fat-free mass index and upper limb lean mass in the＞ 16.40-20.70 cm group were significantly higher than those in the ≤ 12.10 cm group. Therefore, there is a positive correlation between the flexibility and fat-free mass index and upper limb lean mass in college students.