Objective To investigate the influence of liraglutide combined with metformin and simple metformin on insulin re‐sistance in the patients with type 2 diabetes mellitus(T2DM ) .Methods Thirty patients with T2DM treated by liraglutide combined with metformin were collected as the experimental group ,while other 30 patients with T2DM treated by single metformin were col‐lected as the control group .The changes of HbA1c ,HOMA‐IR ,adiponectin ,NO and ET before treatment and at 3 months after treatment were compared between the two groups .Results The decrease degree of HbA1c ,HOMA‐IR ,NO and ET and the in‐crease degree of adipodectin in the experimental group were more significant than those in the control group with statistical differ‐ences between the two groups(P<0 .05) .Conclusion Liraglutide has more significant effect than metformin for improving the in‐sulin resistance in the patients with T2DM .