Objective To describe the prevalence,clinical subtypes and associated risk factors of stroke in urban and rural workers from Lhasa,Tibet,and provide the evidence of prevention and treatment.Methods A retrospective,population-based descriptive analysis of 81298 urban and rural workers in the Cities Staff Medical Insurance Registry was performed; stroke and myocardial infarction were defined by the International Classification of Disease(ICD)-10 coded from hospital records; the prevalence of these 2 dieases were compared,and clinical subtypes and associated risk factors of stroke in these stroke patients were analyzed.Results Stroke patients(n=165)were included in the study with a prevalence of 202.96/100,000(95％CI:170.14-231.32),and this number was significantly larger than that of patients with myocardial infarction(n=14),enjoying a prevalence of 17/100,000.The most common subtype was cerebral infarction,followed by cerebral hemorrhage and subaraclnoid hemorrhage; the prevalence of stroke was significantly different in patients with different ages(ranged from 30 to 89,P＜0.05),and the older of the population,the higher prevalence of the stroke; male population had an obviously higher prevalence of stroke than female population,and the population from Han nationality had an obviously higher prevalence of stroke than population from Tibetan nationality (P＜0.05).Conclusion Stroke is the primary fatal disease for the elderly population from Lhasa,and the primary subtype of stroke is cerebral ischemia; its associated risk factors include age,gender and nationality; and combined hypertension is the main risk factor.