Objective To explore the application effect of personalized lateral decubitus pillow for patients with cervical spine surgery. Methods A totals of 106 patients after cervical spine surgery were recruited and randomly divided into control group (48 cases) and experimental group (58 cases). Patients in the control group used the common pillow when patients lay lateral position-the height of pillow equal to shoulder cheekbone breadth, while experimental group used the personalized lateral decubitus pillow which supported suspended occipitalis and the height of pillow adjusted by individual. The comfort score, incision pain score and last time for lateral position of all patients were compared. Results The comfort score of the experimental group was significantly higher than that of the control group during the first day, second day and the third day after surgery [(66. 3 ± 4. 8) vs (63. 4 ± 3. 5), (68. 4 ± 5. 3) vs (65. 1 ± 4. 6), (71. 3 ± 4. 8) vs (68. 3 ± 4. 4);t=3. 461,3. 473,3. 270, respectively; P <0. 05]. The incision pain score of the experimental group was significantly lower than that of the control group during the first day, second day and the third day after surgery [(5.09±1.33) vs(5.88±1.29),(4.78±1.30) vs(5.52±1.09),(4.33±1.13) vs(5.06±1.06);t=3. 127,3. 157,3. 427, respectively;P<0. 05]. The last time of the experimental group for lateral position were longer than that of control group [(88. 6 ± 15. 2) min vs (79. 3 ± 14. 1) min; t = -3. 239,P =0. 002]. Conclusions It can increase the comfort score, extend the last time for lateral position and lessen incision pain to use the individuation lateral position pillow for patients after cervical spine surgery.