Objective To explore the effect of intervention by follow-up on sexual quality of young and middle aged male patients with chronic heart failure.Methods Seventy-eight patients with chronic heart failure in our hospital were enrolled into this study and randomly divided into the study group (n=40) and the control group (n=38).Psychological intervention during follow-up was carried out in the study group.The sexual quality of life after discharge for six month was investigated and evaluated with a retrospective questionnaire in two groups.Result Sexual quality of life in the study group was significantly improved compared to the control group (P<0.001).Conclusion Psychological intervention during follow-ups can increase sexual quality of life in young and middle aged male patients with chronic heart failure.